The Effect of Nitric Oxide Supplied to the Sweep Gas of the Oxygenator on the Formation of Gaseous Microemboli during Cardiopulmonary Bypass (Experimental Study)

The Effect of Nitric Oxide Supplied to the Sweep Gas of the Oxygenator on the Formation of Gaseous Microemboli during Cardiopulmonary Bypass (Experimental Study)

The effect of nitric oxide (NO) supplied to the sweep gas of the oxygenator on the formation of gaseous microemboli during cardiopulmonary bypass has been studied in animal experiments (female pigs). It was shown that NO added to the sweep gas of the oxygenator during cardiopulmonary bypass signific...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 177; no. 6; pp. 787 - 791
Main Authors: Marichev, A. O., Radovskiy, A. M., Osovskikh, V. V., Kozyrev, D. A., Chomakhashvili, I. G., Lomaev, A. A., Sorokina, A. K., Chinenkov, I. A., Vasilchenko, O. I., Avezov, D. A., Kalinin, M. O., Bautin, A. E.
Format: Journal Article
Language:English
Published: New York Springer US 01-10-2024
Springer Nature B.V
Subjects:
Anesthesia
Animals
Arterial lines
Biomedical and Life Sciences
Biomedicine
Biotechnology
Brain injury
Cell Biology
Drug dosages
Heart surgery
Internal Medicine
Laboratory Medicine
Medical research
Nitric oxide
Ostomy
Pathology
Phosphopyruvate hydratase
Pore size
Sensors
Surgical apparatus & instruments
cardiopulmonary bypass
nitric oxide
neuron-specific enolase
gas embolism
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Summary:The effect of nitric oxide (NO) supplied to the sweep gas of the oxygenator on the formation of gaseous microemboli during cardiopulmonary bypass has been studied in animal experiments (female pigs). It was shown that NO added to the sweep gas of the oxygenator during cardiopulmonary bypass significantly decreased the number and volume of microemboli (the number of microemboli over 1 h of cardiopulmonary bypass was 1197 (568; 2436) vs 55,478 (15,217; 331,480) in the control; p =0.016). The decrease in the number and volume of all bubbles was accompanied by a significant decrease in the concentration of neuron-specific enolase, a marker of brain injury, 6 h after the end of cardiopulmonary bypass to 7.7 (7.5; 8.7) ng/ml vs 11.2 (9.2; 18.3) ng/ml in the group without NO ( p =0.047).
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ISSN:0007-4888
1573-8221
1573-8221
DOI:10.1007/s10517-024-06268-9