Search Results - "Lollo, Charles P"

Strength of conjugate binding to plasmid DNA affects degradation rate and expression level in vivo by Mullen, Patricia M, Lollo, Charles P, Phan, Quynh-Chi, Amini, Arjang, Banaszczyk, Mariusz G, Fabrycki, Joanne M, Wu, Dongpei, Carlo, Alison T, Pezzoli, Patrick, Coffin, Christopher C, Carlo, Dennis J

“…In vitro assays have demonstrated the capability of poly- L-lysine to protect plasmid DNA from serum nucleases and cellular lysates. Our purpose was to…”
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Development and validation of a liquid chromatography method for simultaneous determination of three process-related impurities: yeastolates, triton X-100 and methotrexate by Fang, Shiping, Lollo, Charles P., Derunes, Celine, LaBarre, Michael J.

“…► We measured process-related impurities (yeastolates, triton X-100 and methotrexate) in rHuPH20 in-process and manufacturing materials. ► We developed and…”
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Stabilization of poly- l-lysine/DNA polyplexes for in vivo gene delivery to the liver by Kwoh, Deborah Y., Coffin, Christopher C., Lollo, Charles P., Jovenal, Jocelyn, Banaszczyk, Mariusz G., Mullen, Patricia, Phillips, Alison, Amini, Arjang, Fabrycki, Joanne, Bartholomew, Richard M., Brostoff, Steven W., Carlo, Dennis J.

“…We are developing a self-assembling non-viral in vivo gene delivery vehicle based on poly- l-lysine and plasmid DNA. We have characterized poly- l-lysines of…”
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Poly-L-lysine-based gene delivery systems. Synthesis, purification, and application by Lollo, Charles P, Banaszczyk, Mariusz G, Mullen, Patricia M, Coffin, Christopher C, Wu, Dongpei, Carlo, Alison T, Bassett, Donna L, Gouveia, Erin K, Carlo, Dennis J

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Gene therapy strategies for the treatment of chronic viral hepatitis by Chiou, H C, Lucas, M A, Coffin, C C, Banaszczyk, M G, Ill, C R, Lollo, C P

“…Chronic viral hepatitis is a major clinical problem, with over half a billion persons infected worldwide. Current therapies, principally treatment with…”
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DNA condensation for gene therapy as monitored by atomic force microscopy by Hansma, Helen G., Golan, Roxana, Hsieh, Wan, Lollo, Charles P., Mullen-Ley, Patricia, Kwoh, Deborah

“…The atomic force microscope (AFM) was used to assay the extent of DNA condensation in ∼100 different complexes of DNA with polylysine (PL) or PL covalently…”
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Therapy of peritoneal carcinomatosis of human colon cancer xenografts with yttrium 90-labeled anti-carcinoembryonic antigen antibody ZCE025 by Hyams, D M, Esteban, J M, Lollo, C P, Beatty, B G, Beatty, J D

“…The present study was undertaken to determine whether an anti-carcinoembryonic antigen (CEA) monoclonal antibody (MAB), labeled with the potent beta emitter…”
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POLY-L-LYSINE-GRAFT-PEG COMB-TYPE POLYCATION COPOLYMERS FOR GENE DELIVERY by BANASZCZYK, MARIUSZ G., LOLLO, CHARLES P., KWOH, DEBORAH Y., PHILLIPS, ALISON T., AMINI, ARJANG, WU, DUNCAN P., MULLEN, PATRICIA M., COFFIN, CHRISTOPHER C., BROSTOFF, STEVEN W., CARLO, DENNIS J.

“…Polycations have been used for gene delivery in vitro quite successfully, however, in vivo applications suffered from serum effects that lower the overall gene…”
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Non-viral gene delivery: vehicle and delivery characterization by Lollo, C P, Kwoh, D Y, Mockler, T C, Ley, P M, Guido, M S, Coffin, C C, Aleman, R, Bartholomew, R M, Carlo, D J

“…The development of non-viral gene therapy has been hampered by an inability to reproducibly manufacture and characterize delivery system components and final…”
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