Search Results - "Lolicato, Fabio"

Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins by Sciacca, Michele F, Lolicato, Fabio, Tempra, Carmelo, Scollo, Federica, Sahoo, Bikash R, Watson, Matthew D, García-Viñuales, Sara, Milardi, Danilo, Raudino, Antonio, Lee, Jennifer C, Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

“…An increasing number of human diseases has been shown to be linked to aggregation and amyloid formation by intrinsically disordered proteins (IDPs). Amylin,…”
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SNAP25 disease mutations change the energy landscape for synaptic exocytosis due to aberrant SNARE interactions by Kádková, Anna, Murach, Jacqeline, Østergaard, Maiken, Malsam, Andrea, Malsam, Jörg, Lolicato, Fabio, Nickel, Walter, Söllner, Thomas H, Sørensen, Jakob Balslev

“…SNAP25 is one of three neuronal SNAREs driving synaptic vesicle exocytosis. We studied three mutations in SNAP25 that cause epileptic encephalopathy: V48F, and…”
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The Role of Cholesterol in Driving IAPP-Membrane Interactions by Sciacca, Michele F.M., Lolicato, Fabio, Di Mauro, Giacomo, Milardi, Danilo, D’Urso, Luisa, Satriano, Cristina, Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

“…Our knowledge of the molecular events underlying type 2 diabetes mellitus—a protein conformational disease characterized by the aggregation of islet amyloid…”
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Dimerization of the pulmonary surfactant protein C in a membrane environment by Korolainen, Hanna, Lolicato, Fabio, Enkavi, Giray, Pérez-Gil, Jesús, Kulig, Waldemar, Vattulainen, Ilpo

“…Surfactant protein C (SP-C) has several functions in pulmonary surfactant. These include the transfer of lipids between different membrane structures, a role…”
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Lipid-assisted protein transport: A diffusion-reaction model supported by kinetic experiments and molecular dynamics simulations by La Rosa, Carmelo, Scalisi, Silvia, Lolicato, Fabio, Pannuzzo, Martina, Raudino, Antonio

“…The protein transport inside a cell is a complex phenomenon that goes through several difficult steps. The facilitated transport requires sophisticated…”
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A Role for Liquid-Ordered Plasma Membrane Nanodomains Coordinating the Unconventional Secretory Pathway of Fibroblast Growth Factor 2? by Lolicato, Fabio, Nickel, Walter

“…Fibroblast growth factor 2 (FGF2) is a tumor cell survival factor that belongs to a subgroup of extracellular proteins lacking N-terminal signal peptides…”
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Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space by Lolicato, Fabio, Steringer, Julia P, Saleppico, Roberto, Beyer, Daniel, Fernandez-Sobaberas, Jaime, Unger, Sebastian, Klein, Steffen, Riegerová, Petra, Wegehingel, Sabine, Müller, Hans-Michael, Schmitt, Xiao J, Kaptan, Shreyas, Freund, Christian, Hof, Martin, Šachl, Radek, Chlanda, Petr, Vattulainen, Ilpo, Nickel, Walter

“…Fibroblast growth factor 2 (FGF2) exits cells by direct translocation across the plasma membrane, a type I pathway of unconventional protein secretion. This…”
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Negatively Charged Gangliosides Promote Membrane Association of Amphipathic Neurotransmitters by Juhola, Hanna, Postila, Pekka A., Rissanen, Sami, Lolicato, Fabio, Vattulainen, Ilpo, Róg, Tomasz

“…[Display omitted] •Anionic ganglioside GM1 facilitates membrane association of amphipathic histamine.•GM1 promotes membrane association of amphipathic…”
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Overlay databank unlocks data-driven analyses of biomolecules for all by Kiirikki, Anne M., Antila, Hanne S., Bort, Lara S., Buslaev, Pavel, Favela-Rosales, Fernando, Ferreira, Tiago Mendes, Fuchs, Patrick F. J., Garcia-Fandino, Rebeca, Gushchin, Ivan, Kav, Batuhan, Kučerka, Norbert, Kula, Patrik, Kurki, Milla, Kuzmin, Alexander, Lalitha, Anusha, Lolicato, Fabio, Madsen, Jesper J., Miettinen, Markus S., Mingham, Cedric, Monticelli, Luca, Nencini, Ricky, Nesterenko, Alexey M., Piggot, Thomas J., Piñeiro, Ángel, Reuter, Nathalie, Samantray, Suman, Suárez-Lestón, Fabián, Talandashti, Reza, Ollila, O. H. Samuli

“…Tools based on artificial intelligence (AI) are currently revolutionising many fields, yet their applications are often limited by the lack of suitable…”
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Symmetry-breaking transitions in the early steps of protein self-assembly by La Rosa, Carmelo, Condorelli, Marcello, Compagnini, Giuseppe, Lolicato, Fabio, Milardi, Danilo, Do, Trang Nhu, Karttunen, Mikko, Pannuzzo, Martina, Ramamoorthy, Ayyalusamy, Fraternali, Franca, Collu, Francesca, Rezaei, Human, Strodel, Birgit, Raudino, Antonio

“…Protein misfolding and subsequent self-association are complex, intertwined processes, resulting in development of a heterogeneous population of aggregates…”
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Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components by Steringer, Julia P, Lange, Sascha, Čujová, Sabína, Šachl, Radek, Poojari, Chetan, Lolicato, Fabio, Beutel, Oliver, Müller, Hans-Michael, Unger, Sebastian, Coskun, Ünal, Honigmann, Alf, Vattulainen, Ilpo, Hof, Martin, Freund, Christian, Nickel, Walter

“…FGF2 is secreted from cells by an unconventional secretory pathway. This process is mediated by direct translocation across the plasma membrane. Here, we…”
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In vivo characterization of the bacterial intramembrane-cleaving protease RseP using the heme binding tag-based assay iCliPSpy by Kupke, Thomas, Götz, Rabea M., Richter, Florian M., Beck, Rainer, Lolicato, Fabio, Nickel, Walter, Hopf, Carsten, Brügger, Britta

“…Regulated intramembrane proteolysis (RIP) describes the protease-dependent cleavage of transmembrane proteins within the hydrophobic core of cellular…”
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The Na,K-ATPase acts upstream of phosphoinositide PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2 by Legrand, Cyril, Saleppico, Roberto, Sticht, Jana, Lolicato, Fabio, Müller, Hans-Michael, Wegehingel, Sabine, Dimou, Eleni, Steringer, Julia P., Ewers, Helge, Vattulainen, Ilpo, Freund, Christian, Nickel, Walter

“…FGF2 is a tumor cell survival factor that is exported from cells by an ER/Golgi-independent secretory pathway. This unconventional mechanism of protein…”
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Phosphoinositide switches in cell physiology - From molecular mechanisms to disease by Lolicato, Fabio, Nickel, Walter, Haucke, Volker, Ebner, Michael

“…Phosphoinositides are amphipathic lipid molecules derived from phosphatidylinositol that represent low abundance components of biological membranes. Rather…”
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The role of alpha-helix on the structure-targeting drug design of amyloidogenic proteins by Tempra, Carmelo, La Rosa, Carmelo, Lolicato, Fabio

“…The most accredited hypothesis links the toxicity of amyloid proteins to their harmful effects on membrane integrity through the formation of…”
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A unifying framework for amyloid-mediated membrane damage: The lipid-chaperone hypothesis by Tempra, Carmelo, Scollo, Federica, Pannuzzo, Martina, Lolicato, Fabio, La Rosa, Carmelo

“…Over the past thirty years, researchers have highlighted the role played by a class of proteins or polypeptides that forms pathogenic amyloid aggregates in…”
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doGlycans–Tools for Preparing Carbohydrate Structures for Atomistic Simulations of Glycoproteins, Glycolipids, and Carbohydrate Polymers for GROMACS by Danne, Reinis, Poojari, Chetan, Martinez-Seara, Hector, Rissanen, Sami, Lolicato, Fabio, Róg, Tomasz, Vattulainen, Ilpo

“…Carbohydrates constitute a structurally and functionally diverse group of biological molecules and macromolecules. In cells they are involved in, e.g., energy…”
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Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study by Lolicato, Fabio, Raudino, Antonio, Milardi, Danilo, La Rosa, Carmelo

“…Amyloid aggregation of islet amyloid polypeptide (IAPP) in pancreatic tissues is a typical feature of type 2 diabetes mellitus. Resveratrol, a natural product…”
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A critical role for cholesterol in PI(4,5)P2-dependent unconventional secretion of fibroblast growth factor 2 by Lolicato, Fabio, Saleppico, Roberto, Griffo, Alessandra, Bruegger, Britta, Jacobs, Karin, Vattulainen, Ilpo, Nickel, Walter

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Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes by Scollo, Federica, Tempra, Carmelo, Lolicato, Fabio, Sciacca, Michele F. M, Raudino, Antonio, Milardi, Danilo, La Rosa, Carmelo

“…Amyloidogenic proteins are involved in many diseases, including Alzheimer’s, Parkinson’s, and type II diabetes. These proteins are thought to be toxic for…”
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