Search Results - "Lokhandwala, Mustafa F"

Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats by Bhatt, Siddhartha R., Lokhandwala, Mustafa F., Banday, Anees Ahmad

“…Endothelial dysfunction is a hallmark of hypertension and vascular oxidative stress can contribute to endothelial dysfunction and hypertension development…”
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Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice by Farooqui, Zeba, Mohammad, Razia Sultana, Lokhandwala, Mustafa F., Banday, Anees Ahmad

“…Oxidative stress and renal inflammation play a pivotal role in the pathogenesis of hypertension. The redox-sensitive transcription factor, nuclear factor…”
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Protein disulfide isomerase inhibition impairs Keap1/Nrf2 signaling and mitochondrial function and induces apoptosis in renal proximal tubular cells by Pokkunuri, Indira D, Lokhandwala, Mustafa F, Banday, Anees Ahmad

“…Renal proximal tubular apoptosis plays a critical role in kidney health and disease. However, cellular molecules that trigger renal apoptosis remain elusive…”
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Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats by Javkhedkar, Apurva A, Quiroz, Yasmir, Rodriguez-Iturbe, Bernardo, Vaziri, Nosratola D, Lokhandwala, Mustafa F, Banday, Anees A

“…Compelling evidence supports the role of oxidative stress and renal interstitial inflammation in the pathogenesis of hypertension. Resveratrol is a…”
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Renal Dopamine Oxidation and Inflammation in High Salt Fed Rats by Banday, Anees A, Lokhandwala, Mustafa F

“…Background Oxidative stress and high salt intake could be independent or intertwined risk factors in the origin of hypertension. Kidneys are the major organ to…”
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Altered Functioning of Both Renal Dopamine D1 and Angiotensin II Type 1 Receptors Causes Hypertension in Old Rats by Chugh, Gaurav, Lokhandwala, Mustafa F, Asghar, Mohammad

“…Activation of renal dopamine D1 (D1R) and angiotensin II type 1 receptors (AT1Rs) influences the activity of proximal tubular sodium transporter Na,K-ATPase…”
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Age-Related Mitochondrial Impairment and Renal Injury Is Ameliorated by Sulforaphane via Activation of Transcription Factor NRF2 by Mohammad, Razia Sultana, Lokhandwala, Mustafa F, Banday, Anees A

“…Age is one of the major risk factors for the development of chronic pathologies, including kidney diseases. Oxidative stress and mitochondrial dysfunction play…”
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Angiotensin II-mediated biphasic regulation of proximal tubular Na+/H+ exchanger 3 is impaired during oxidative stress by Banday, Anees Ahmad, Lokhandwala, Mustafa F

“…Angiotensin (ANG) II via AT1 receptors (AT1Rs) maintains sodium homeostasis by regulating renal sodium transporters including Na(+)/H(+) exchanger 3 (NHE3) in…”
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Oxidative stress impairs cGMP-dependent protein kinase activation and vasodilator-stimulated phosphoprotein serine-phosphorylation by Banday, Anees A., Lokhandwala, Mustafa F.

“…Reactive oxygen species induce vascular dysfunction and hypertension by directly interacting with nitric oxide (NO) which leads to NO inactivation. In addition…”
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Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats by Asghar, Mohammad, George, Liza, Lokhandwala, Mustafa F

“…Recently, we reported that oxidative stress decreases D1 receptor numbers and G protein activation in renal proximal tubules (RPT), resulting in diminished…”
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Oxidative Stress Causes Renal Angiotensin II Type 1 Receptor Upregulation, Na+/H+ Exchanger 3 Overstimulation, and Hypertension by Banday, Anees A, Lokhandwala, Mustafa F

“…Oxidative stress modulates angiotensin (Ang) II type 1 receptor (AT1R) expression and function. Ang II activates renal Na/H exchanger 3 (NHE3) to increase…”
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Dopamine and vascular dynamics control: present status and future perspectives by Tayebati, Seyed Khosrow, Lokhandwala, Mustafa F, Amenta, Francesco

“…The catecholamine dopamine is a precursors in the biosynthesis of norepinephrine and epinephrine as well as a neurotransmitter in the central nervous system…”
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Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters and hypertension by Banday, Anees Ahmad, Lokhandwala, Mustafa F

“…Reactive oxygen species have emerged as important molecules in cardiovascular dysfunction such as diabetes and hypertension. Recent work has shown that…”
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Renal dopamine receptors and hypertension by Hussain, Tahir, Lokhandwala, Mustafa F

“…Dopamine has been recognized as an important modulator of central as well as peripheral physiologic functions in both humans and animals. Dopamine receptors…”
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Loss of Biphasic Effect on Na/K-ATPase Activity by Angiotensin II Involves Defective Angiotensin Type 1 Receptor–Nitric Oxide Signaling by Banday, Anees Ahmad, Lokhandwala, Mustafa F

“…Oxidative stress causes changes in angiotensin (Ang) type 1 receptor (AT1R) function, which contributes to hypertension. Ang II affects blood pressure via…”
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Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats by Trivedi, Meghna, Lokhandwala, Mustafa F

“…Dopamine D(1A) receptor function is impaired in obesity-induced insulin resistance, contributing to sodium retention. We showed previously that uncoupling of…”
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Tempol Reduces Oxidative Stress, Improves Insulin Sensitivity, Decreases Renal Dopamine D1 Receptor Hyperphosphorylation, and Restores D1 Receptor–G-Protein Coupling and Function in Obese Zucker Rats by BANDAY, Anees Ahmad, MARWAHA, Aditi, TALLAM, Lakshmi S, LOKHANDWALA, Mustafa F

“…Tempol Reduces Oxidative Stress, Improves Insulin Sensitivity, Decreases Renal Dopamine D1 Receptor Hyperphosphorylation, and Restores D1 Receptor–G-Protein…”
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Angiotensin (1‐7) exerts antioxidant effects, inhibits mTOR signaling and protects against endoplasmic reticulum stress and apoptosis in HK2 cells by Farooqui, Zeba, Lokhandwala, Mustafa F., Banday, Anees A.

“…Angiotensin (Ang) 1‐7, a bioactive heptapeptide of the renin‐angiotensin aldosterone system is known to exert antioxidant and nephroprotective effects…”
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Renal Dopamine Receptor Function in Hypertension by Hussain, Tahir, Lokhandwala, Mustafa F

“…Dopamine plays an important role in the regulation of renal sodium excretion. The synthesis of dopamine and the presence of dopamine receptor subtypes (D1A,…”
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Exercise activates redox-sensitive transcription factors and restores renal D1 receptor function in old rats by George, Liza, Lokhandwala, Mustafa F, Asghar, Mohammad

“…We have previously reported that age-associated oxidative stress via protein kinase C (PKC) increases D1 receptor (D1R) phosphorylation and causes D1R-G…”
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