Search Results - "Lokesh, Ganesh L. R"

Morph-X-Select: Morphology-based tissue aptamer selection for ovarian cancer biomarker discovery by Wang, Hongyu, Li, Xin, Volk, David E, Lokesh, Ganesh L-R, Elizondo-Riojas, Miguel-Angel, Li, Li, Nick, Alpa M, Sood, Anil K, Rosenblatt, Kevin P, Gorenstein, David G

“…High affinity aptamer-based biomarker discovery has the advantage of simultaneously discovering an aptamer affinity reagent and its target biomarker protein…”
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Conversion of RNA Aptamer into Modified DNA Aptamers Provides for Prolonged Stability and Enhanced Antitumor Activity by Amero, Paola, Lokesh, Ganesh L. R, Chaudhari, Rajan R, Cardenas-Zuniga, Roberto, Schubert, Thomas, Attia, Yasmin M, Montalvo-Gonzalez, Efigenia, Elsayed, Abdelrahman M, Ivan, Cristina, Wang, Zhihui, Cristini, Vittorio, Franciscis, Vittorio de, Zhang, Shuxing, Volk, David E, Mitra, Rahul, Rodriguez-Aguayo, Cristian, Sood, Anil K, Lopez-Berestein, Gabriel

“…Aptamers, synthetic single-strand oligonucleotides that are similar in function to antibodies, are promising as therapeutics because of their minimal side…”
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Development of Phosphorothioate DNA and DNA Thioaptamers by Volk, David E, Lokesh, Ganesh L R

“…Nucleic acid aptamers are short RNA- or DNA-based affinity reagents typically selected from combinatorial libraries to bind to a specific target such as a…”
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A Unique and Simple Approach to Improve Sensitivity in 15N-NMR Relaxation Measurements for NH3+ Groups: Application to a Protein-DNA Complex by Nguyen, Dan, Lokesh, Ganesh, Volk, David, Iwahara, Junji

“…NMR spectroscopy is a powerful tool for research on protein dynamics. In the past decade, there has been significant progress in the development of NMR methods…”
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Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice by Kang, Shin-Ae, Tsolmon, Bilegtsaikhan, Mann, Aman P., Zheng, Wei, Zhao, Lichao, Zhao, Yan Daniel, Volk, David E., Lokesh, Ganesh L.-R., Morris, Lynsie, Gupta, Vineet, Razaq, Wajeeha, Rui, Hallgeir, Suh, K. Stephen, Gorenstein, David G., Tanaka, Takemi

“…The medical applications of aptamers have recently emerged. We developed an antagonistic thioaptamer (ESTA) against E-selectin. Previously, we showed that a…”
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Therapeutic Targeting of AXL Receptor Tyrosine Kinase Inhibits Tumor Growth and Intraperitoneal Metastasis in Ovarian Cancer Models by Kanlikilicer, Pinar, Ozpolat, Bulent, Aslan, Burcu, Bayraktar, Recep, Gurbuz, Nilgun, Rodriguez-Aguayo, Cristian, Bayraktar, Emine, Denizli, Merve, Gonzalez-Villasana, Vianey, Ivan, Cristina, Lokesh, Ganesh L.R., Amero, Paola, Catuogno, Silvia, Haemmerle, Monika, Wu, Sherry Yen-Yao, Mitra, Rahul, Gorenstein, David G., Volk, David E., de Franciscis, Vittorio, Sood, Anil K., Lopez-Berestein, Gabriel

“…Despite substantial improvements in the treatment strategies, ovarian cancer is still the most lethal gynecological malignancy. Identification of drug…”
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Thioaptamers targeting dengue virus type-2 envelope protein domain III by Gandham, Sai Hari A, Volk, David E, Lokesh, Ganesh L R, Neerathilingam, Muniasamy, Gorenstein, David G

“…Thioaptamers targeting the dengue-2 virus (DENV-2) envelope protein domain III (EDIII) were developed. EDIII, which contains epitopes for binding neutralizing…”
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Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer by Whiting, Nicholas, Hu, Jingzhe, Zacharias, Niki M, Lokesh, Ganesh L. R, Volk, David E, Menter, David G, Rupaimoole, Rajesha, Previs, Rebecca, Sood, Anil K, Bhattacharya, Pratip

“…Silicon-based nanoparticles are ideally suited for use as biomedical imaging agents due to their biocompatibility, biodegradability, and simple surface…”
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Thioaptamer targeted discoidal microparticles increase self immunity and reduce Mycobacterium tuberculosis burden in mice by Leonard, Fransisca, Ha, Ngan P., Sule, Preeti, Alexander, Jenolyn F., Volk, David E., Lokesh, Ganesh L.R., Liu, Xuewu, Cirillo, Jeffrey D., Gorenstein, David G., Yuan, Jinyun, Chatterjee, Soumya, Graviss, Edward A., Godin, Biana

“…Worldwide, tuberculosis (TB) remains one of the most prevalent infectious diseases causing morbidity and death in >1.5 million patients annually. Mycobacterium…”
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Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer by Morita, Yoshihiro, Leslie, Macall, Kameyama, Hiroyasu, Lokesh, Ganesh L R, Ichimura, Norihisa, Davis, Rachel, Hills, Natalie, Hasan, Nafis, Zhang, Roy, Kondo, Yuji, Gorenstein, David G, Volk, David E, Chervoneva, Inna, Rui, Hallgeir, Tanaka, Takemi

“…Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy…”
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Improving vascular maturation using noncoding RNAs increases antitumor effect of chemotherapy by Mangala, Lingegowda S, Wang, Hongyu, Jiang, Dahai, Wu, Sherry Y, Somasunderam, Anoma, Volk, David E, Lokesh, Ganesh L R, Li, Xin, Pradeep, Sunila, Yang, Xianbin, Haemmerle, Monika, Rodriguez-Aguayo, Cristian, Nagaraja, Archana S, Rupaimoole, Rajesha, Bayraktar, Emine, Bayraktar, Recep, Li, Li, Tanaka, Takemi, Hu, Wei, Ivan, Cristina, Gharpure, Kshipra M, McGuire, Michael H, Thiviyanathan, Varatharasa, Zhang, Xinna, Maiti, Sourindra N, Bulayeva, Nataliya, Choi, Hyun-Jin, Dorniak, Piotr L, Cooper, Laurence Jn, Rosenblatt, Kevin P, Lopez-Berestein, Gabriel, Gorenstein, David G, Sood, Anil K

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Improving vascular maturation using noncoding RNAs increases antitumor effect of chemotherapy by Mangala, Lingegowda S, Wang, Hongyu, Jiang, Dahai, Wu, Sherry Y, Somasunderam, Anoma, Volk, David E, Lokesh, Ganesh L R, Li, Xin, Pradeep, Sunila, Yang, Xianbin, Haemmerle, Monika, Rodriguez-Aguayo, Cristian, Nagaraja, Archana S, Rupaimoole, Rajesha, Bayraktar, Emine, Bayraktar, Recep, Li, Li, Tanaka, Takemi, Hu, Wei, Ivan, Cristina, Gharpure, Kshipra M, McGuire, Michael H, Thiviyanathan, Varatharasa, Zhang, Xinna, Maiti, Sourindra N, Bulayeva, Nataliya, Choi, Hyun-Jin, Dorniak, Piotr L, Cooper, Laurence Jn, Rosenblatt, Kevin P, Lopez-Berestein, Gabriel, Gorenstein, David G, Sood, Anil K

“…Current antiangiogenesis therapy relies on inhibiting newly developed immature tumor blood vessels and starving tumor cells. This strategy has shown transient…”
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Improving vascular maturation using noncoding RNAs increases antitumor effect of chemotherapy by Mangala, Lingegowda S, Wang, Hongyu, Jiang, Dahai, Wu, Sherry Y, Somasunderam, Anoma, Volk, David E, Lokesh, Ganesh L R, Li, Xin, Pradeep, Sunila, Yang, Xianbin, Haemmerle, Monika, Rodriguez-Aguayo, Cristian, Nagaraja, Archana S, Rupaimoole, Rajesha, Bayraktar, Emine, Bayraktar, Recep, Li, Li, Tanaka, Takemi, Hu, Wei, Ivan, Cristina, Gharpure, Kshipra M, McGuire, Michael H, Thiviyanathan, Varatharasa, Zhang, Xinna, Maiti, Sourindra N, Bulayeva, Nataliya, Choi, Hyun-Jin, Dorniak, Piotr L, Cooper, Laurence Jn, Rosenblatt, Kevin P, Lopez-Berestein, Gabriel, Gorenstein, David G, Sood, Anil K

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E-selectin Targeting PEGylated-thioaptamer Prevents Breast Cancer Metastases by Morita, Yoshihiro, Kamal, Mohamed, Kang, Shin-Ae, Zhang, Roy, Lokesh, Ganesh LR, Thiviyanathan, Varatharasa, Hasan, Nafis, Woo, Sukyung, Zhao, Daniel, Leslie, Macall, Suh, Stephen, Razaq, Wajeeha, Rui, Hallgeir, Gorenstein, David G, Volk, David E, Tanaka, Takemi

“…E-selectin is an adhesion molecule expressed on the luminal surface of inflamed blood vessels that mediates hematogenous metastasis by assisting…”
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A Unique and Simple Approach to Improve Sensitivity in 15 N-NMR Relaxation Measurements for NH₃⁺ Groups: Application to a Protein-DNA Complex by Nguyen, Dan, Lokesh, Ganesh L R, Volk, David E, Iwahara, Junji

“…NMR spectroscopy is a powerful tool for research on protein dynamics. In the past decade, there has been significant progress in the development of NMR methods…”
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X-Aptamer Technology Identifies C4A and ApoB in Blood as Potential Markers for Schizophrenia by Walss-Bass, Consuelo, Lokesh, Ganesh L R, Dyukova, Elena, Gorenstein, David G, Roberts, David L, Velligan, Dawn, Volk, David E

“…The field of proteomics is rapidly gaining territory as a promising alternative to genomic approaches in the efforts to unravel the complex molecular…”
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