Search Results - "Lokappa, Sowmya Bekshe"

α-Synuclein Populates Both Elongated and Broken Helix States on Small Unilamellar Vesicles by Lokappa, Sowmya Bekshe, Ulmer, Tobias S.

“…The misfolding of the protein α-synuclein (αS) has been implicated in the molecular chain of events leading to Parkinson disease. Physiologically, αS undergoes…”
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Dark noise and retinal degeneration from D190N-rhodopsin by Silverman, Daniel, Chai, Zuying, Yue, Wendy W. S., Ramisetty, Sravani Keerthi, Lokappa, Sowmya Bekshe, Sakai, Kazumi, Frederiksen, Rikard, Bina, Parinaz, Tsang, Stephen H., Yamashita, Takahiro, Chen, Jeannie, Yau, King-Wai

“…Numerous rhodopsin mutations have been implicated in night blindness and retinal degeneration, often with unclear etiology. D190N-rhodopsin (D190N-Rho) is a…”
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Interactions of amelogenin with phospholipids by Bekshe Lokappa, Sowmya, Balakrishna Chandrababu, Karthik, Dutta, Kaushik, Perovic, Iva, Spencer Evans, John, Moradian-Oldak, Janet

“…ABSTRACT Amelogenin protein has the potential to interact with other enamel matrix proteins, mineral, and cell surfaces. We investigated the interactions of…”
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Isoelectric Focusing to Quantify Rhodopsin Phosphorylation in Mouse Retina by Lokappa, Sowmya Bekshe, Cornwall, M Carter, Chen, Jeannie

“…Rhodopsin is a G-protein coupled receptor (GPCR) that mediates vision under dim light. Upon light exposure, rhodopsin is phosphorylated at multiple serine and…”
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Amelogenin Processing by MMP-20 Prevents Protein Occlusion Inside Calcite Crystals by Bromley, Keith M, Lakshminarayanan, Rajamani, Thompson, Mitchell, Lokappa, Sowmya Bekshe, Gallon, Victoria A, Cho, Kang Rae, Qiu, S. Roger, Moradian-Oldak, Janet

“…Calcite crystals were grown in the presence of full-length amelogenin and during its proteolysis by recombinant human matrix metalloproteinase 20 (rhMMP-20)…”
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Gene co-expression network analysis for identifying genetic markers in Parkinson's disease - a three-way comparative approach by George, Gincy, Singh, Sachidanand, Lokappa, Sowmya Bekshe, Varkey, Jobin

“…Parkinson's disease (PD) is a neurodegenerative disorder involving progressive deterioration of dopaminergic neurons. Although few genetic markers for familial…”
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Congenital Generalized Lipodystrophy Mutation p.Glu176Argfs Renders Cavin-1 Leucine Zipper Domain 2 to Off-Targets by Mohapatra, Anshuman, Bekshe Lokappa, Sowmya, Chaudhary, Nitin

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Interaction of cavin-1/PTRF leucine zipper domain 2 and its congenital generalized lipodystrophy mutant with model membranes by Mohapatra, Anshuman, Lokappa, Sowmya Bekshe, Chaudhary, Nitin

“…The organization of caveolae ultrastructures in the plasma membrane and the functions they dictate are mediated by membrane-embedded caveolins (caveolin-1, 2,…”
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Construction of Parkinson's disease marker-based weighted protein-protein interaction network for prioritization of co-expressed genes by George, Gincy, Valiya Parambath, Snijesh, Lokappa, Sowmya Bekshe, Varkey, Jobin

“…Background: Parkinson's disease (PD) is a complex neurodegenerative movement disorder that primarily results due to the loss of dopaminergic neurons in the…”
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Tooth enamel protein amelogenin binds to ameloblast cell membrane-mimicking vesicles via its N-terminus by Lokappa, Sowmya Bekshe, Chandrababu, Karthik Balakrishna, Moradian-Oldak, Janet

“…We have recently reported that the extracellular enamel protein amelogenin has affinity to interact with phospholipids and proposed that such interactions may…”
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Dissecting amelogenin protein nanospheres: characterization of metastable oligomers by Bromley, Keith M, Kiss, Andrew S, Lokappa, Sowmya Bekshe, Lakshminarayanan, Rajamani, Fan, Daming, Ndao, Moise, Evans, John Spencer, Moradian-Oldak, Janet

“…Amelogenin self-assembles to form an extracellular protein matrix, which serves as a template for the continuously growing enamel apatite crystals. To gain…”
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Interaction of peptides spanning the transmembrane domain of caveolin-1 with model membranes by Lokappa, Sowmya Bekshe, Nagaraj, Ramakrishnan

“…Caveolin‐1 has an atypical membrane‐spanning domain comprising of 34 residues. Caveolin‐1 targets to lipid droplets under certain conditions, where they are…”
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Interactions of amelogenin with phospholipids by Bekshe Lokappa, Sowmya, Chandrababu, Karthik Balakrishna, Dutta, Kaushik, Perovic, Iva, Evans, John Spencer, Moradian-Oldak, Janet

“…Amelogenin protein has the potential to interact with other enamel matrix proteins, mineral, and cell surfaces. In this paper, we investigated the interactions…”
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The Clustering and Spatial Arrangement of β-Sheet Sequence, but Not Order, Govern α-Synuclein Fibrillogenesis by Suk, Jae-Eun, Lokappa, Sowmya Bekshe, Ulmer, Tobias S

“…The intrinsically unstructured protein α-synuclein (aS) is prone to misfold into cytotoxic β-sheet-rich oligomers and amyloid fibrils that underlie the…”
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Structural adaptation of tooth enamel protein amelogenin in the presence of SDS micelles by Chandrababu, Karthik Balakrishna, Dutta, Kaushik, Lokappa, Sowmya Bekshe, Ndao, Moise, Evans, John Spencer, Moradian-Oldak, Janet

“…ABSTRACT Amelogenin, the major extracellular matrix protein of developing tooth enamel is intrinsically disordered. Through its interaction with other proteins…”
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Analysis of co-assembly and co-localization of ameloblastin and amelogenin by Mazumder, Parichita, Prajapati, Saumya, Lokappa, Sowmya Bekshe, Gallon, Victoria, Moradian-Oldak, Janet

“…Epithelially-derived ameloblasts secrete extracellular matrix proteins including amelogenin, enamelin, and ameloblastin. Complex intermolecular interactions…”
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The Clustering and Spatial Arrangement of b-Sheet Sequence, but Not Order, Govern a-Synuclein Fibrillogenesis by Suk, Jae-Eun, Lokappa, Sowmya Bekshe, Ulmer, Tobias S

“…The intrinsically unstructured protein *a-synuclein (aS) is prone to misfold into cytotoxic *b-sheet-rich oligomers and amyloid fibrils that underlie the…”
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Dissecting Amelogenin Protein Nanospheres by Bromley, Keith M., Kiss, Andrew S., Lokappa, Sowmya Bekshe, Lakshminarayanan, Rajamani, Fan, Daming, Ndao, Moise, Evans, John Spencer, Moradian-Oldak, Janet

“…Amelogenin self-assembles to form an extracellular protein matrix, which serves as a template for the continuously growing enamel apatite crystals. To gain…”
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