Search Results - "Lok, J B"

Transgenesis in Strongyloides and related parasitic nematodes: historical perspectives, current functional genomic applications and progress towards gene disruption and editing by Lok, J B, Shao, H, Massey, H C, Li, X

“…Transgenesis for Strongyloides and Parastrongyloides was accomplished in 2006 and is based on techniques derived for Caenorhabditis elegans over two decades…”
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Imaging trematode and nematode parasites by Pearce, E. J., Lok, J. B.

“…Summary Recent advances in molecular genetics and in imaging mean that it is now increasingly feasible to image biological processes within helminth parasites…”
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Induction of protective immunity against larval Onchocerca volvulus in a mouse model by Lange, A M, Yutanawiboonchai, W, Lok, J B, Trpis, M, Abraham, D

“…BALB/cBYJ mice were immunized against larval Onchocerca volvulus by subcutaneous injection of normal, irradiated, or freeze-thaw-killed Onchocerca sp. larvae…”
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Transgenesis and neuronal ablation in parasitic nematodes: revolutionary new tools to dissect host-parasite interactions by LOK, J.B, ARTIS, D

“…Ease of experimental gene transfer into viral and prokaryotic pathogens has made transgenesis a powerful tool for investigating the interactions of these…”
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Activity of an injectable, sustained-release formulation of moxidectin administered prophylactically to mixed-breed dogs to prevent infection with Dirofilaria immitis by Lok, J B, Knight, D H, Wang, G T, Doscher, M E, Nolan, T J, Hendrick, M J, Steber, W, Heaney, K

“…To test the ability of a single injection of a sustained-release formulation of moxidectin (moxidectin SR) to protect dogs against heartworm infection for 180…”
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Strongyloides stercoralis: maintenance of exceedingly chronic infections by Mansfield, L S, Niamatali, S, Bhopale, V, Volk, S, Smith, G, Lok, J B, Genta, R M, Schad, G A

“…Two hypotheses were tested to identify the mechanism(s) by which chronic Strongyloides stercoralis infections are maintained in experimental dogs as a model to…”
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SEASONAL PREVALENCE OF THIRD-STAGE LARVAE OF DIROFILARIA IMMITIS IN MOSQUITOES FROM FLORIDA AND LOUISIANA by Watts, K. J, Reddy, G. R, Holmes, R. A, Lok, J. B, Knight, D. H, Smith, G, Courtney, C. H

“…Heads of 109,597 mosquitoes collected during 1996 and 1997 from Gainesville, Florida (1996, n = 39,131; 1997, n = 34,209), Bartow, Florida (1996, n = 12,000;…”
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Identification of Surrogate Rodent Hosts for Larval Onchocerca lienalis and Induction of Protective Immunity in a Model System by Abraham, David, Eberhard, Mark L., Lange, Anna Marie, Yutanawiboonchai, Wiboonchai, Perler, Francine B., Lok, James B.

“…The objectives of this project were to screen a variety of inbred rodent species and strains to determine their usefulness as surrogate hosts for the study of…”
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Transgene expression in Strongyloides stercoralis following gonadal microinjection of DNA constructs by Lok, James B, Massey, Holman C

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Structure and developmental expression of Strongyloides stercoralis fktf-1, a proposed ortholog of daf-16 in Caenorhabditis elegans by Massey, Holman C., Nishi, Manami, Chaudhary, Kshitiz, Pakpour, Nazzy, Lok, James B.

“…A forkhead transcription factor gene, fktf-1, which we propose to be orthologous to the Caenorhabditis elegans dauer-regulatory gene daf-16 has been discovered…”
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Abnormal patterns of embryogenesis in Dirofilaria immitis treated with ivermectin by Lok, J B, Harpaz, T, Knight, D H

“…The percentage composition and spatial distribution of embryogenic stages in the uteri of female Dirofilaria immitis were examined at various times after…”
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Entomological studies at an enzootic Venezuelan equine encephalitis virus focus in Guatemala, 1977-1980 by Cupp, E W, Scherer, W F, Lok, J B, Brenner, R J, Dziem, G M, Ordonez, J V

“…The ecology of several potential mosquito vectors of Venezuelan equine encephalitis (VEE) alphavirus was studied in an enzootic focus of that virus on the…”
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Experimental ocular onchocerciasis in cynomolgus monkeys by DONNELLY, J. J, TAYLOR, H. R, YOUNG, E, KHATAMI, M, LOK, J. B, ROCKEY, J. H

“…Infection of cynomolgus monkeys with microfilariae (Mf) of Onchocerca lienalis was studied as a model for human ocular onchocerciasis. Normal monkeys and…”
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Further studies on the development of onchocerca spp. (Nematoda: Filarioidea) in Nearctic black flies (Diptera: Simuliidae) by Lok, J B, Cupp, E W, Bernardo, M J, Pollack, R J

“…Of three species of Nearctic black flies tested, Simulium pictipes Hagen proved the most efficient laboratory vector of the bovine parasite Onchocerca…”
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Studies of the Growth-Regulating Effects of Ivermectin on Larval Onchocerca lienalis In vitro by Lok, J. B., Pollack, R. J., Donnelly, J. J.

“…At concentrations of 0.1-100 ng/ml ivermectin inhibited L3-L4 molting by Onchocerca lienalis in vitro. The degree of inhibition was dose-dependent with a…”
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Survival and viability of Dirofilaria immitis microfilariae in defined and undefined culture media by Abraham, D, Lauria, S, Mika-Grieve, M, Lok, J.B, Grieve, R.B

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PCR amplification of putative gpa-2 and gpa-3 orthologs from the (A+T)-rich genome of Strongyloides stercoralis by Massey, Holman C., Ball, Curtis C., Lok, James B.

“…Two G protein α subunit genes orthologous to gpa-2 and gpa-3 in Caenorhabditis elegans have been identified in the parasitic nematode, Strongyloides…”
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In vitro development of third- and fourth-stage larvae of Dirofilaria immitis: comparison of basal culture media, serum levels and possible serum substitutes by Lok, J B, Mika-Grieve, M, Grieve, R B, Chin, T K

“…In vitro development and survival of third-stage larvae of Dirofilaria immitis were compared in four different culture media and in the presence of varying…”
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Recovery and viability of Dirofilaria immitis microfilariae by Grieve, R B, Mika-Grieve, M, Lok, J B, Marchell, T F, Cupp, E W

“…The viability of Dirofilaria immitis microfilariae recovered from canine blood by different methods was determined. Microfilaria recovery techniques included…”
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Autoantibody induced by experimental Onchocerca infection. Effect of different routes of administration of microfilariae and of treatment with diethylcarbamazine citrate and ivermectin by Donnelly, JJ, Xi, MS, Haldar, JP, Hill, DE, Lok, JB, Khatami, M, Rockey, JH

“…Hartley guinea pigs were injected with microfilariae (Mf) of Onchocerca lienalis as a model for acute inflammatory responses to Mf in human Onchocerca volvulus…”
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