Search Results - "Lok, B.H"

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    The Effect of PARP Inhibitor Radiosensitization on the mRNA Translational Regulation of T Cell Chemokines by Ran, X., Zhang, X., Teng, M., Alawi, W.B., Nahum, S., He, H., Lok, B.H.

    “…Immunotherapy has modestly improved survival for small cell lung cancer (SCLC) patients. Low response rate and rapid disease progression remain an intractable…”
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    Journal Article
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    Phase I Trial of Concurrent Talazoparib and Consolidative Thoracic Radiotherapy for Patients with Extensive-Stage Small Cell Lung Cancer by Lok, B.H., Sacher, A.G., Bezjak, A., Raman, S., Hope, A.J., Sun, A., Leighl, N., Eng, L., Shepherd, F., Liu, G., Bradbury, P.

    “…For patients with extensive-stage (ES) small cell lung cancer (SCLC), systemic therapy followed by low dose consolidative thoracic radiotherapy (CTRT) is a…”
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    Cross-Cancer Analysis Reveals Distinct Pattern of Immune Modulation during Curative Radiotherapy by Said, B. Id, Boukhaled, G., Lok, B.H., Lukovic, J., Mesci, A., Waldron, J.N., Wong, P., Wang, B.X., Brooks, D.G., Milosevic, M.

    “…Radiation therapy (RT) is a cornerstone in the curative treatment of solid tumors, yet its complex effects on the immune system are not fully understood. The…”
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    Stereotactic Ablative Radiotherapy for Ultra-Central Lung Tumors: Local Control and Toxicity from a Seventeen-Year Single-Institution Experience by Safavi, S.A.H., Santiago, A.T., Torres, C., Raman, S., Lok, B.H., Hope, A.J., Bezjak, A., Sun, A.Y., Wu, G., Bissonnette, J.P., Cho, B.C.J., Giuliani, M.E.

    “…Stereotactic ablative radiotherapy (SABR) for ultra-central (UC) lung tumors can be associated with morbidity and mortality. We report local control (LC) and…”
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    RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination by Lok, B H, Carley, A C, Tchang, B, Powell, S N

    Published in Oncogene (25-07-2013)
    “…Synthetic lethality is an approach to study selective cell killing based on genotype. Previous work in our laboratory has shown that loss of RAD52 is…”
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    Journal Article
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