Search Results - "Loirand, G."

A new pathophysiological element in severe asthma: GTPase Rac by Hassoun, D, Loirand, G, Sauzeau, V

“…Asthma is a chronic airway condition defined by hyperresponsiveness, bronchial remodeling and chronic inflammation. A significant proportion of severe…”
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Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension by Agard, C, Rolli‐Derkinderen, M, Dumas‐de‐La‐Roque, E, Rio, M, Sagan, C, Savineau, JP, Loirand, G, Pacaud, P

“…Background and purpose:  Pulmonary arterial hypertension (PAH) is associated with increased contraction and proliferation of pulmonary vascular smooth muscle…”
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Characterization of 3D bifurcations in micro-scan and MRA-TOF images of cerebral vasculature for prediction of intra-cranial aneurysms by Nouri, A., Autrusseau, F., Bourcier, R., Gaignard, A., L’allinec, V., Menguy, C., Véziers, J., Desal, H., Loirand, G., Redon, R.

“…[Display omitted] •We propose a geometrical characterisation of cerebral tree bifurcations.•A 3D skeleton associated with a graph provide an accurate…”
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Extract from Mimosa pigra attenuates chronic experimental pulmonary hypertension by Rakotomalala, G., Agard, C., Tonnerre, P., Tesse, A., Derbré, S., Michalet, S., Hamzaoui, J., Rio, M., Cario-Toumaniantz, C., Richomme, P., Charreau, B., Loirand, G., Pacaud, P.

“…Different parts of Mimosa pigra (MPG) are used in traditional medicine in Madagascar, tropical Africa, South America and Indonesia for various troubles…”
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Rho kinase inhibitors for pulmonary hypertension: waiting for clinical evidence by Pacaud, P, Loirand, G

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Increased β2 -adrenergic vasorelaxation at the early phase of endotoxemic shock in rats by Roul, D, Rozec, B, André, G, Merlet, N, Tran Quang, T, Lauzier, B, Ferron, M, Blanloeil, Y, Loirand, G, Sauzeau, V, Gauthier, C

“…Abstract Background and purpose The early management of the cardiovascular dysfunction of septic shock is critical as it is associated with a poor outcome…”
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PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension by Berger, J.M, Vaillant, N, Claderon, C, Brégeon, J, Le May, C, Hadchouel, J, Costet, P, Loirand, G, Cariou, B

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Rho exchange factors in the cardiovascular system by Loirand, Gervaise, Scalbert, Elizabeth, Bril, Antoine, Pacaud, Pierre

“…Increasing evidence has accumulated to implicate overactivation of Rho protein as a common component for the pathogenesis of several cardiovascular disorders…”
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PO14 Cytosquelette d’actine et protéine G Rac1, cibles potentielles pour le traitement de l’insulinorésistance by Bertrand, L, Auquier, J, Renguet, E, Gélinas, R, Sauzeau, V, Loirand, G, Kienlen-Campard, P, Hue, L, Vanoverschelde, J.-L, Beauloye, C, Horman, S, Ginion, A

“…Introduction Nous avons précédemment montré que l’activation de la protéine kinase activée par l’AMP (AMPK) par les biguanides (metformine ou phenformine)…”
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Release of Ca2+ by noradrenaline and ATP from the same Ca2+ store sensitive to both InsP3 and Ca2+ in rat portal vein myocytes by Pacaud, P, Loirand, G

“…1. Changes in cytosolic free Ca2+ concentration ([Ca2+]i) induced by noradrenaline (NA) and ATP were investigated using indo-1 microspectrofluorimetry in…”
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Noradrenaline-activated heparin-sensitive Ca2+ entry after depletion of intracellular Ca2+ store in portal vein smooth muscle cells by PACAUD, P, LOIRAND, G, GREGOIRE, G, MIRONNEAU, C, MIRONNEAU, J

“…Single portal vein smooth muscle cells were voltage-clamped using the whole cell patch-clamp technique. Intracellular free Ca2+ concentration ([Ca2+]i) was…”
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Ca2+ and Sr2+ entry induced Ca2+ release from the intracellular Ca2+ store in smooth muscle cells of rat portal vein by Grégoire, G, Loirand, G, Pacaud, P

“…1. Changes in cytosolic free Ca2+ concentration ([Ca2+]i) induced by membrane depolarizations were investigated using indo-1 microspectrofluorimetry in single…”
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Neointimal hyperplasia after stenting in a human mammary artery organ culture by Guérin, P, Rondeau, F, Grimandi, G, Heymann, M F, Heymann, D, Pillet, P, Al Habash, O, Loirand, G, Pacaud, P, Crochet, D

“…Although the use of stents has limited the incidence of restenosis, in-stent restenosis remains an important problem. In-stent restenosis is the result of a…”
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D021 Sildenafil induced-revascularization of rat hindlimb involved arteriogenesis through PI3K/-Akt and eNOS activation by Menguy, C, Bocquet, A, Guihot, A.-L, Toutain, B, Rolli-derkinderen, M, Chappard, D, Pacaud, P, Loirand, G, Henrion, D, Loufrani, L

“…Hypoxia and inflammation play a major role in the revascularization following ischemia. Sildenafil inhibits phosphodiesterase-5, increases intracellular cGMP…”
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I025 Smooth muscle specific deletion of the RhoA exchange factor Arhgef1 protects against Ang II-dependent hypertension by Bregeon, J, Guilluy, C, Toumaniantz, G, Rolliderkinderen, M, Retailleau, K, Loufrani, L, Henrion, D, Scalbert, E, Bril, A, Pacaud, P, Loirand, G

“…Hypertension is one of the most frequent pathology in the industrialized world. Although it is recognized to be dependent on a combination of genetic and…”
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Rho Kinases in Cardiovascular Physiology and Pathophysiology by Loirand, Gervaise, Guérin, Patrice, Pacaud, Pierre

“…Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein RhoA. In addition to their effect on actin organization, or…”
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Large conductance calcium-activated non-selective cation channel in smooth muscle cells isolated from rat portal vein by Loirand, G, Pacaud, P, Baron, A, Mironneau, C, Mironneau, J

“…1. Membrane currents of isolated smooth muscle cells from rat portal vein were studied using the whole-cell patch-clamp technique. 2. In addition to the…”
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GTP-binding proteins mediate noradrenaline effects on calcium and chloride currents in rat portal vein myocytes by Loirand, G, Pacaud, P, Mironneau, C, Mironneau, J

“…1. Membrane currents were recorded by a patch-clamp pipette technique in cultured cells from rat portal vein using the whole-cell mode. 2. Noradrenaline (NA,…”
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Pathways and receptors involved in peptide YY induced contraction of rat proximal colonic muscle in vitro by Ferrier, L, Segain, J-P, Pacaud, P, Cherbut, C, Loirand, G, Galmiche, J-P, Blottière, H M

“…BACKGROUND Peptide YY (PYY) is involved in the regulation of several gut functions, including secretion and motility. It exerts its effects through a family of…”
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Effect of extracellular ATP on cytosolic Ca2+ concentration in rat pulmonary artery myocytes by Guibert, C, Pacaud, P, Loirand, G, Marthan, R, Savineau, J P

“…Changes in cytosolic free Ca2+ concentration ([Ca2+]i) induced by ATP and other P2 purinoceptor agonists were investigated using indo 1 microspectrofluorimetry…”
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