Search Results - "Lohse, Martin J"

Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription by Godbole, Amod, Lyga, Sandra, Lohse, Martin J., Calebiro, Davide

“…A new paradigm of G-protein-coupled receptor (GPCR) signaling at intracellular sites has recently emerged, but the underlying mechanisms and functional…”
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Dimerization in GPCR mobility and signaling by Lohse, Martin J

“…Many types of cell surface as well as intracellular DNA-binding receptors exist and function as dimers; formation of homodimers or heterodimers appears to not…”
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Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling by Anton, Selma E., Kayser, Charlotte, Maiellaro, Isabella, Nemec, Katarina, Möller, Jan, Koschinski, Andreas, Zaccolo, Manuela, Annibale, Paolo, Falcke, Martin, Lohse, Martin J., Bock, Andreas

“…G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular functions. Cells express many different GPCRs, but all these GPCRs…”
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Optical Mapping of cAMP Signaling at the Nanometer Scale by Bock, Andreas, Annibale, Paolo, Konrad, Charlotte, Hannawacker, Annette, Anton, Selma E., Maiellaro, Isabella, Zabel, Ulrike, Sivaramakrishnan, Sivaraj, Falcke, Martin, Lohse, Martin J.

“…Cells relay a plethora of extracellular signals to specific cellular responses by using only a few second messengers, such as cAMP. To explain signaling…”
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G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives by Ferré, Sergi, Casadó, Vicent, Devi, Lakshmi A, Filizola, Marta, Jockers, Ralf, Lohse, Martin J, Milligan, Graeme, Pin, Jean-Philippe, Guitart, Xavier

“…Most evidence indicates that, as for family C G protein-coupled receptors (GPCRs), family A GPCRs form homo- and heteromers. Homodimers seem to be a…”
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Single-molecule analysis of fluorescently labeled G-protein–coupled receptors reveals complexes with distinct dynamics and organization by Calebiro, Davide, Rieken, Finn, Wagner, Julia, Sungkaworn, Titiwat, Zabel, Ulrike, Borzi, Alfio, Cocucci, Emanuele, Zürn, Alexander, Lohse, Martin J.

“…G-protein–coupled receptors (GPCRs) constitute the largest family of receptors and major pharmacological targets. Whereas many GPCRs have been shown to form…”
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Signaling by internalized G-protein-coupled receptors by Calebiro, Davide, Nikolaev, Viacheslav O, Persani, Luca, Lohse, Martin J

“…G-protein-coupled receptors (GPCRs) are cell surface receptors and are generally assumed to signal to second messengers such as cyclic AMP (cAMP) exclusively…”
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Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists by Işbilir, Ali, Möller, Jan, Arimont, Marta, Bobkov, Vladimir, Perpiñá-Viciano, Cristina, Hoffmann, Carsten, Inoue, Asuka, Heukers, Raimond, de Graaf, Chris, Smit, Martine J., Annibale, Paolo, Lohse, Martin J.

“…Although class A G protein–coupled receptors (GPCRs) can function as monomers, many of them form dimers and oligomers, but the mechanisms and functional…”
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cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons by Maiellaro, Isabella, Lohse, Martin J., Kittel, Robert J., Calebiro, Davide

“…The second messenger cyclic AMP (cAMP) plays an important role in synaptic plasticity. Although there is evidence for local control of synaptic transmission…”
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Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium by Schiwon, Marzena, Weisheit, Christina, Franken, Lars, Gutweiler, Sebastian, Dixit, Akanksha, Meyer-Schwesinger, Catherine, Pohl, Judith-Mira, Maurice, Nicholas J., Thiebes, Stephanie, Lorenz, Kristina, Quast, Thomas, Fuhrmann, Martin, Baumgarten, Georg, Lohse, Martin J., Opdenakker, Ghislain, Bernhagen, Jürgen, Bucala, Rick, Panzer, Ulf, Kolanus, Waldemar, Gröne, Hermann-Josef, Garbi, Natalio, Kastenmüller, Wolfgang, Knolle, Percy A., Kurts, Christian, Engel, Daniel R.

“…The phagocytes of the innate immune system, macrophages and neutrophils, contribute to antibacterial defense, but their functional specialization and…”
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Cell swelling enhances ligand-driven β-adrenergic signaling by Sirbu, Alexei, Bathe-Peters, Marc, Kumar, Jothi L. M., Inoue, Asuka, Lohse, Martin J., Annibale, Paolo

“…G protein-coupled receptors’ conformational landscape can be affected by their local, microscopic interactions within the cell plasma membrane. We employ here…”
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SARS-CoV2 wild type and mutant specific humoral and T cell immunity is superior after vaccination than after natural infection by Richardson, Jennifer R, Götz, Ralph, Mayr, Vanessa, Lohse, Martin J, Holthoff, Hans-Peter, Ungerer, Martin

“…We investigated blood samples from fully SARS-CoV2-vaccinated subjects and from previously positive tested patients up to one year after infection with…”
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Proteolytic Cleavage of the Extracellular Domain Affects Signaling of Parathyroid Hormone 1 Receptor by Klenk, Christoph, Hommers, Leif, Lohse, Martin J

“…Parathyroid hormone 1 receptor (PTH1R) is a member of the class B family of G protein-coupled receptors, which are characterized by a large extracellular…”
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Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity by Schönegge, Anne-Marie, Gallion, Jonathan, Picard, Louis-Philippe, Wilkins, Angela D., Le Gouill, Christian, Audet, Martin, Stallaert, Wayne, Lohse, Martin J., Kimmel, Marek, Lichtarge, Olivier, Bouvier, Michel

“…Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling…”
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Differential Signaling of the Endogenous Agonists at the β2-Adrenergic Receptor by Reiner, Susanne, Ambrosio, Manuela, Hoffmann, Carsten, Lohse, Martin J.

“…The concept of “functional selectivity” or “biased signaling” suggests that a ligand can have distinct efficacies with regard to different signaling pathways…”
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Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion by Nakagawa, Yuko, Nagasawa, Masahiro, Yamada, Satoko, Hara, Akemi, Mogami, Hideo, Nikolaev, Viacheslav O, Lohse, Martin J, Shigemura, Noriatsu, Ninomiya, Yuzo, Kojima, Itaru

“…Sweet taste receptor is expressed in the taste buds and enteroendocrine cells acting as a sugar sensor. We investigated the expression and function of the…”
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FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells by Nikolaev, Viacheslav O, Börner, Sebastian, Schwede, Frank, Schlipp, Angela, Berisha, Filip, Calebiro, Davide, Lohse, Martin J

“…Real-time measurements of second messengers in living cells, such as cAMP, are usually performed by ratiometric fluorescence resonance energy transfer (FRET)…”
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A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy by Schmitteckert, Eva M, Lohse, Martin J, Lorenz, Kristina, Schmitt, Joachim P

“…Mitogen-activated protein (MAP) kinases are known to promote cardiac hypertrophy, but how upstream hypertrophic signals induce these kinases to cause…”
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Analysis of receptor oligomerization by FRAP microscopy by Bünemann, Moritz, Engelhardt, Stefan, Klotz, Karl-Norbert, Lohse, Martin J, Dorsch, Sandra

“…Dual-color fluorescence recovery after photobleaching (FRAP) is used to investigate dimerization and higher-order complex formation of receptors at the surface…”
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Experimental and mathematical analysis of cAMP nanodomains by Lohse, Christian, Bock, Andreas, Maiellaro, Isabella, Hannawacker, Annette, Schad, Lothar R, Lohse, Martin J, Bauer, Wolfgang R

“…In their role as second messengers, cyclic nucleotides such as cAMP have a variety of intracellular effects. These complex tasks demand a highly organized…”
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