Search Results - "Lohse, Ines"

Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: Potential role of hypoxia by Marie-Egyptienne, Delphine Tamara, Lohse, Ines, Hill, Richard Peter

“…Abstract Numerous studies have demonstrated the presence of cancer stem cells (CSCs) within solid tumors. Although the precursor of these cells is not clearly…”
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mRNA-to-protein translation in hypoxia by Chee, Nancy T, Lohse, Ines, Brothers, Shaun P

“…Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays…”
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Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids by Huang, Ling, Holtzinger, Audrey, Jagan, Ishaan, BeGora, Michael, Lohse, Ines, Ngai, Nicholas, Nostro, Cristina, Wang, Rennian, Muthuswamy, Lakshmi B, Crawford, Howard C, Arrowsmith, Cheryl, Kalloger, Steve E, Renouf, Daniel J, Connor, Ashton A, Cleary, Sean, Schaeffer, David F, Roehrl, Michael, Tsao, Ming-Sound, Gallinger, Steven, Keller, Gordon, Muthuswamy, Senthil K

“…Human pluripotent stem cells can be differentiated into exocrine pancreas progenitor organoids, allowing studies of development and pancreatic cancer modeling…”
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Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies by Yang, Hui, Kurtenbach, Stefan, Guo, Ying, Lohse, Ines, Durante, Michael A., Li, Jianping, Li, Zhaomin, Al-Ali, Hassan, Li, Lingxiao, Chen, Zizhen, Field, Matthew G., Zhang, Peng, Chen, Shi, Yamamoto, Shohei, Li, Zhuo, Zhou, Yuan, Nimer, Stephen D., Harbour, J. William, Wahlestedt, Claes, Xu, Mingjiang, Yang, Feng-Chun

“…Additional Sex Combs-Like 1 (ASXL1) is mutated at a high frequency in all forms of myeloid malignancies associated with poor prognosis. We generated a Vav1…”
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Non-Coding RNAs in Hepatocellular Carcinoma by Korsch, Mascha, Margetts, Alexander, Wahlestedt, Claes, Lohse, Ines

“…Liver cancer ranks as the fourth leading cause of cancer-related deaths. Despite extensive research efforts aiming to evaluate the biological mechanisms…”
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Fair AI-powered orthopedic image segmentation: addressing bias and promoting equitable healthcare by Siddiqui, Ismaeel A., Littlefield, Nickolas, Carlson, Luke A., Gong, Matthew, Chhabra, Avani, Menezes, Zoe, Mastorakos, George M., Thakar, Sakshi Mehul, Abedian, Mehrnaz, Lohse, Ines, Weiss, Kurt R., Plate, Johannes F., Moradi, Hamidreza, Amirian, Soheyla, Tafti, Ahmad P.

“…AI-powered segmentation of hip and knee bony anatomy has revolutionized orthopedics, transforming pre-operative planning and post-operative assessment. Despite…”
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Low-Dose Chidamide Treatment Displays Sex-Specific Differences in the 3xTg-AD Mouse by Dennison, Jessica, Mendez, Armando, Szeto, Angela, Lohse, Ines, Wahlestedt, Claes, Volmar, Claude-Henry

“…Epigenetic compounds have become attractive small molecules for targeting the multifaceted aspects of Alzheimer’s disease (AD). Although AD disproportionately…”
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Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts by Lohse, Ines, Kumareswaran, Ramya, Cao, Pinjiang, Pitcher, Bethany, Gallinger, Steven, Bristow, Robert G, Hedley, David W

“…The BRCA2 gene product plays an important role in DNA double strand break repair. Therefore, we asked whether radiation sensitivity of pancreatic cancers…”
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Effect of high dose per pulse flattening filter-free beams on cancer cell survival by Lohse, Ines, Lang, Stephanie, Hrbacek, Jan, Scheidegger, Stephan, Bodis, Stephan, Macedo, Nadia S, Feng, Jianhua, Lütolf, Urs M, Zaugg, Kathrin

“…Abstract Purpose To investigate if there is a statistically significant difference in cancer cell survival using a high dose per pulse flattening filter-free…”
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Proteomic and transcriptomic analyses identify apo-transcobalamin-II as a biomarker of overall survival in osteosarcoma by Lacinski, Ryan A., Dziadowicz, Sebastian A., Roth, Clark A., Ma, Li, Melemai, Vincent K., Fitzpatrick, Brody, Chaharbakhshi, Edwin, Heim, Tanya, Lohse, Ines, Schoedel, Karen E., Hu, Gangqing, Llosa, Nicolas J., Weiss, Kurt R., Lindsey, Brock A.

“…Background The large-scale proteomic platform known as the SomaScan® assay is capable of simultaneously measuring thousands of proteins in patient specimens…”
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Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma by Lohse, Ines, Al-Ali, Hassan, Volmar, Claude-Henry, D Alvarez Trotta, Annamil, Brothers, Shaun P, Capobianco, Anthony J, Wahlestedt, Claes

“…Esophageal cancer remains one of the hardest cancers to treat with rising incidence rates, low overall survival and high levels of treatment resistance. The…”
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A novel strategy for combination of clofarabine and pictilisib is synergistic in gastric cancer by Khalafi, Shayan, Zhu, Shoumin, Khurana, Rimpi, Lohse, Ines, Giordano, Silvia, Corso, Simona, Al-Ali, Hassan, Brothers, Shaun P., Wahlestedt, Claes, Schürer, Stephan, El-Rifai, Wael

“…•Drug sensitivity testing identified novel drugs like clofarabine effective in treating gastric cancer.•mRNA sequencing can be used to identify agents with…”
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Assessment of hypoxia in the stroma of patient-derived pancreatic tumor xenografts by Lohse, Ines, Lourenco, Corey, Ibrahimov, Emin, Pintilie, Melania, Tsao, Ming-Sound, Hedley, David W

“…The unusually dense stroma of pancreatic cancers is thought to play an important role in their biological aggression. The presence of hypoxia is also…”
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BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT by Copsel, Sabrina N, Lightbourn, Casey O, Barreras, Henry, Lohse, Ines, Wolf, Dietlinde, Bader, Cameron S, Manov, John, Kale, Brandon J, Shah, Devangi, Brothers, Shaun P, Perez, Victor L, Komanduri, Krishna V, Wahlestedt, Claes, Levy, Robert B

“…A recent approach for limiting production of pro-inflammatory cytokines has been to target bromodomain and extra-terminal (BET) proteins. These epigenetic…”
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Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma by Lacinski, Ryan A, Dziadowicz, Sebastian A, Melemai, Vincent K, Fitzpatrick, Brody, Pisquiy, John J, Heim, Tanya, Lohse, Ines, Schoedel, Karen E, Llosa, Nicolas J, Weiss, Kurt R, Lindsey, Brock A

“…Patients diagnosed with advanced osteosarcoma, often in the form of lung metastases, have abysmal five-year overall survival rates. The complexity of the…”
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Fbxw7 Deletion Accelerates KrasG12D -Driven Pancreatic Tumorigenesis via Yap Accumulation by Zhang, Qiang, Zhang, Yaqing, Parsels, Joshua D, Lohse, Ines, Lawrence, Theodore S, Pasca di Magliano, Marina, Sun, Yi, Morgan, Meredith A

“…Abstract Pancreatic cancers driven by KRAS mutations require additional mutations for tumor progression. The tumor suppressor FBXW7 is altered in pancreatic…”
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The CPT1C 5'UTR contains a repressing upstream open reading frame that is regulated by cellular energy availability and AMPK by Lohse, Ines, Reilly, Patrick, Zaugg, Kathrin

“…Translational control is utilized as a means of regulating gene expression in many species. In most cases, posttranscriptional regulatory mechanisms play an…”
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Pathogenesis and Treatment of Pancreatic Cancer Related Pain by Lohse, Ines, Brothers, Shaun P

“…Pancreatic cancer is often diagnosed due to the patient seeking medical attention for abdominal pain. It is among the most painful cancers, with pain severity…”
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The CPT1C 5′UTR Contains a Repressing Upstream Open Reading Frame That Is Regulated by Cellular Energy Availability and AMPK by Lohse, Ines, Reilly, Patrick, Zaugg, Kathrin

“…Background Translational control is utilized as a means of regulating gene expression in many species. In most cases, posttranscriptional regulatory mechanisms…”
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Naturally occurring compounds as pancreatic cancer therapeutics by Lohse, Ines, Wildermuth, Erin, Brothers, Shaun P

“…Naturally occurring small molecule compounds have long been in the spotlight of pancreatic cancer research as potential therapeutics to prevent cancer…”
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