Search Results - "Lohr, Nicole L"
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Red/near infrared light stimulates release of an endothelium dependent vasodilator and rescues vascular dysfunction in a diabetes model
Published in Free radical biology & medicine (01-12-2017)“…Peripheral artery disease (PAD) is a morbid condition whereby ischemic peripheral muscle causes pain and tissue breakdown. Interestingly, PAD risk factors,…”
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Electromagnetic energy (670 nm) stimulates vasodilation through activation of the large conductance potassium channel (BKCa)
Published in PloS one (01-01-2021)“…Peripheral artery disease (PAD) is a highly morbid condition in which impaired blood flow to the limbs leads to pain and tissue loss. Previously we identified…”
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Vitamin E Attenuates Red-Light-Mediated Vasodilation: The Benefits of a Mild Oxidative Stress
Published in Antioxidants (29-05-2024)“…Red light (670 nm) energy controls vasodilation via the formation of a transferable endothelium-derived nitric oxide (NO)-precursor-containing substance, its…”
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In Vivo Characterization of a Red Light-Activated Vasodilation: A Photobiomodulation Study
Published in Frontiers in physiology (02-05-2022)“…Nitric oxide dependent vasodilation is an effective mechanism for restoring blood flow to ischemic tissues. Previously, we established an murine model whereby…”
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Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: Potential role in cardioprotection
Published in Journal of molecular and cellular cardiology (01-08-2009)“…Abstract Nitric oxide is an important messenger in numerous biological processes, such as angiogenesis, hypoxic vasodilation, and cardioprotection. Although…”
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Ascorbate attenuates red light mediated vasodilation: Potential role of S-nitrosothiols
Published in Redox biology (01-01-2019)“…There is significant therapeutic advantage of nitric oxide synthase (NOS) independent nitric oxide (NO) production in maladies where endothelium, and thereby…”
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Isoflurane Differentially Modulates Mitochondrial Reactive Oxygen Species Production via Forward versus Reverse Electron Transport Flow
Published in Anesthesiology (Philadelphia) (01-09-2011)“…Background Reactive oxygen species (ROS) mediate the effects of anesthetic precondition to protect against ischemia and reperfusion injury, but the mechanisms…”
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An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice
Published in PloS one (06-04-2016)“…Interferon regulatory factor 5 (IRF5) has been called a "master switch" for its ability to determine whether cells mount proinflammatory or anti-inflammatory…”
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Red Light Mitigates the Deteriorating Placental Extracellular Matrix in Late Onset of Preeclampsia and Improves the Trophoblast Behavior
Published in Journal of pregnancy (20-04-2022)“…Preeclampsia is a serious pregnancy disorder which in extreme cases may lead to maternal and fetal injury or death. Preexisting conditions which increase…”
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Successful infusional 5-fluorouracil administration in a patient with vasospastic angina
Published in American heart journal plus (01-05-2022)“…A 48-year-old female with metastatic colon adenocarcinoma and history of pre-existing coronary vasospasm with ventricular tachycardia (VT) successfully…”
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Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis
Published in American Journal of Physiology: Cell Physiology (01-03-2011)“…Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by oxidative stress, impaired vascular function, and attenuated…”
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Wavelength-dependence of vasodilation and NO release from S-nitrosothiols and dinitrosyl iron complexes by far red/near infrared light
Published in Archives of biochemistry and biophysics (01-07-2018)“…Far red/near infrared (R/NIR) energy is a novel therapy, but its mechanism of action is poorly characterized. Cytochrome c oxidase (Cco) of the mitochondrial…”
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Red light stimulates vasodilation through extracellular vesicle trafficking
Published in Journal of photochemistry and photobiology. B, Biology (01-07-2021)“…Red light (670 nm) promotes ex vivo dilation of blood vessels in a nitric oxide (NO) dependent, but eNOS independent manner by secreting a quasi-stable and…”
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Red light mediates the exocytosis of vasodilatory vesicles from cultured endothelial cells: a cellular, and ex vivo murine model
Published in Photochemical & photobiological sciences (01-02-2024)“…We have previously established that 670 nm energy induces relaxation of blood vessels via an endothelium derived S-nitrosothiol (RSNO) suggested to be embedded…”
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Function over form: Is it time to use endothelial function to diagnose vascular diseases?
Published in International journal of cardiology (01-06-2018)Get full text
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Chronic hyperglycemia attenuates coronary collateral development and impairs proliferative properties of myocardial interstitial fluid by production of angiostatin
Published in Circulation (New York, N.Y.) (18-05-2004)“…Development of coronary collateral vessels is impaired in patients with diabetes mellitus. We tested the hypothesis that hyperglycemia alone attenuates…”
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Collateral Development: The Quest Continues
Published in Circulation research (14-02-2014)Get full text
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The HFSA Advanced Heart Failure and Transplant Cardiology Fellowship Consensus Conference
Published in Journal of cardiac failure (01-02-2024)“…There is waning interest among cardiology trainees in pursuing an Advanced Heart Failure/Transplant Cardiology (AHFTC) fellowship as evidenced by fewer…”
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Isoflurane Differentially Modulates Mitochondrial Reactive Oxygen Species Production via Forward versus Reverse Electron Transport Flow: Implications for Preconditioning
Published in Anesthesiology (Philadelphia) (01-09-2011)“…Reactive oxygen species (ROS) mediate the effects of anesthetic precondition to protect against ischemia and reperfusion injury, but the mechanisms of ROS…”
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