Search Results - "Lohoff, Tim"

Multi-omics profiling of mouse gastrulation at single-cell resolution by Argelaguet, Ricard, Clark, Stephen J., Mohammed, Hisham, Stapel, L. Carine, Krueger, Christel, Kapourani, Chantriolnt-Andreas, Imaz-Rosshandler, Ivan, Lohoff, Tim, Xiang, Yunlong, Hanna, Courtney W., Smallwood, Sebastien, Ibarra-Soria, Ximena, Buettner, Florian, Sanguinetti, Guido, Xie, Wei, Krueger, Felix, Göttgens, Berthold, Rugg-Gunn, Peter J., Kelsey, Gavin, Dean, Wendy, Nichols, Jennifer, Stegle, Oliver, Marioni, John C., Reik, Wolf

“…Formation of the three primary germ layers during gastrulation is an essential step in the establishment of the vertebrate body plan and is associated with…”
Get full text

Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency by Kalkan, Tüzer, Bornelöv, Susanne, Mulas, Carla, Diamanti, Evangelia, Lohoff, Tim, Ralser, Meryem, Middelkamp, Sjors, Lombard, Patrick, Nichols, Jennifer, Smith, Austin

“…The gene regulatory network (GRN) of naive mouse embryonic stem cells (ESCs) must be reconfigured to enable lineage commitment. TCF3 sanctions rewiring by…”
Get full text

The Circadian Clock Modulates Global Daily Cycles of mRNA Ribosome Loading by Missra, Anamika, Ernest, Ben, Lohoff, Tim, Jia, Qidong, Satterlee, James, Ke, Kenneth, von Arnim, Albrecht G.

“…Circadian control of gene expression is well characterized at the transcriptional level, but little is known about diel or circadian control of translation…”
Get full text

Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis by Clark, Stephen J, Argelaguet, Ricard, Lohoff, Tim, Krueger, Felix, Drage, Deborah, Göttgens, Berthold, Marioni, John C, Nichols, Jennifer, Reik, Wolf

“…Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases…”
Get full text

Inactivation of Cancer Mutations Utilizing CRISPR/Cas9 by Gebler, Christina, Lohoff, Tim, Paszkowski-Rogacz, Maciej, Mircetic, Jovan, Chakraborty, Debojyoti, Camgoz, Aylin, Hamann, Martin V, Theis, Mirko, Thiede, Christian, Buchholz, Frank

“…Although whole-genome sequencing has uncovered a large number of mutations that drive tumorigenesis, functional ratification for most mutations remains sparse…”
Get full text

An exemplary subsidization path for the green hydrogen economy uptake: Rollout policies in the United States and the European Union by Gatto, Andrea, Sadik-Zada, Elkhan Richard, Lohoff, Tim, Aldieri, Luigi, Vinci, Concetto Paolo, Peitz, Kevin Alexander

“…The present paper reviews the green hydrogen uptake policies in the United States and the European Union. While the EU has a rather broad public support…”
Get full text

Investing in vision: Innovation in retinal therapeutics and the influence on venture capital investment by Hristodorov, Dmitrij, Lohoff, Tim, Luneborg, Nanna, Mulder, Geert-Jan, Clark, Simon J

“…Since the groundbreaking approval of the first anti-VEGF therapy in 2004, the retinal therapeutics field has undergone a remarkable transformation, witnessing…”
Get full text

3078 – EOMESODERMIN IS A PIVOTAL REGULATOR OF YOLK SAC BLOOD AND ENDOTHELIAL DEVELOPMENT by Harland, Luke, Theeuwes, Bart, Bisia, Alexandra, Ton, Mai-Linh, Argelaguet, Ricard, Clark, Stephen, Lohoff, Tim, Wilson, Nicola, Reik, Wolf, Robertson, Elizabeth, Gottgens, Bertie

Get full text

Metabolic control of DNA methylation in naive pluripotent cells by Betto, Riccardo M., Diamante, Linda, Perrera, Valentina, Audano, Matteo, Rapelli, Stefania, Lauria, Andrea, Incarnato, Danny, Arboit, Mattia, Pedretti, Silvia, Rigoni, Giovanni, Guerineau, Vincent, Touboul, David, Stirparo, Giuliano Giuseppe, Lohoff, Tim, Boroviak, Thorsten, Grumati, Paolo, Soriano, Maria E., Nichols, Jennifer, Mitro, Nico, Oliviero, Salvatore, Martello, Graziano

“…Naive epiblast and embryonic stem cells (ESCs) give rise to all cells of adults. Such developmental plasticity is associated with genome hypomethylation. Here,…”
Get full text

Distinct Molecular Trajectories Converge to Induce Naive Pluripotency by Stuart, Hannah T., Stirparo, Giuliano G., Lohoff, Tim, Bates, Lawrence E., Kinoshita, Masaki, Lim, Chee Y., Sousa, Elsa J., Maskalenka, Katsiaryna, Radzisheuskaya, Aliaksandra, Malcolm, Andrew A., Alves, Mariana R.P., Lloyd, Rebecca L., Nestorowa, Sonia, Humphreys, Peter, Mansfield, William, Reik, Wolf, Bertone, Paul, Nichols, Jennifer, Göttgens, Berthold, Silva, José C.R.

“…Understanding how cell identity transitions occur and whether there are multiple paths between the same beginning and end states are questions of wide…”
Get full text