Search Results - "Lohoff, Falk"

Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders: A Multivariable Mendelian Randomization Analysis by Rosoff, Daniel B, Smith, George Davey, Lohoff, Falk W

“…Growing evidence suggests that prescription opioid use affects depression and anxiety disorders; however, observational studies are subject to confounding,…”
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Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study by Rosoff, Daniel B, Davey Smith, George, Mehta, Nehal, Clarke, Toni-Kim, Lohoff, Falk W

“…Alcohol consumption and smoking, 2 major risk factors for cardiovascular disease (CVD), often occur together. The objective of this study is to use a wide…”
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Overview of the Genetics of Major Depressive Disorder by Lohoff, Falk W.

“…Major depressive disorder (MDD) is a common psychiatric illness with high levels of morbidity and mortality. Despite intensive research during the past several…”
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Pharmacotherapies and personalized medicine for alcohol use disorder: a review by Lohoff, Falk W

“…Alcohol use disorder (AUD) is highly prevalent and among the leading causes of morbidity and mortality in the United States. Pharmacotherapies for AUD are…”
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Targeting Unmet Clinical Needs in the Treatment of Alcohol Use Disorder by Lohoff, Falk W.

“…Alcohol Use Disorder (AUD) is a chronic psychiatric disorder marked by impaired control over drinking behavior that poses a significant challenge to the…”
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Random forest based classification of alcohol dependence patients and healthy controls using resting state MRI by Zhu, Xi, Du, Xiaofei, Kerich, Mike, Lohoff, Falk W., Momenan, Reza

“…•Diagnosis of alcohol use disorder using resting state functional connectivity.•Quantify resting-state within-network and between-network connectivity features…”
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Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function by Rosoff, Daniel B., Bell, Andrew S., Jung, Jeesun, Wagner, Josephin, Mavromatis, Lucas A., Lohoff, Falk W.

“…Lipid-lowering therapy with statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition are effective strategies in reducing cardiovascular…”
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Overview of the Genetics of Alcohol Use Disorder by Tawa, Elisabeth A, Hall, Samuel D, Lohoff, Falk W

“…Alcohol Use Disorder (AUD) is a chronic psychiatric illness characterized by harmful drinking patterns leading to negative emotional, physical, and social…”
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Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system by Bell, Andrew S., Wagner, Josephin, Rosoff, Daniel B., Lohoff, Falk W.

“…The gene encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and its protein product have been widely studied for their role in cholesterol and…”
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Lipid-Lowering Drug Effects Beyond the Cardiovascular System: Relevance for Neuropsychiatric Disorders by Lohoff, Falk W

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Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in the Brain and Relevance for Neuropsychiatric Disorders by O'Connell, Emma M, Lohoff, Falk W

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) has long been studied in the liver due to its regulation of plasma low-density lipoprotein cholesterol…”
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Association Between Brain Structure and Alcohol Use Behaviors in Adults: A Mendelian Randomization and Multiomics Study by Mavromatis, Lucas A, Rosoff, Daniel B, Cupertino, Renata B, Garavan, Hugh, Mackey, Scott, Lohoff, Falk W

“…Past studies have identified associations between brain macrostructure and alcohol use behaviors. However, identifying directional associations between these…”
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Epigenetics of alcohol use disorder—A review of recent advances in DNA methylation profiling by Longley, Martha J., Lee, Jisoo, Jung, Jeesun, Lohoff, Falk W.

“…Alcohol use disorder (AUD) is a major contributor to morbidity and mortality worldwide. Although there is a heritable component, the etiology of AUD is complex…”
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Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2 by Luo, Audrey, Jung, Jeesun, Longley, Martha, Rosoff, Daniel B, Charlet, Katrin, Muench, Christine, Lee, Jisoo, Hodgkinson, Colin A, Goldman, David, Horvath, Steve, Kaminsky, Zachary A, Lohoff, Falk W

“…To investigate the potential role of alcohol use disorder (AUD) in aging processes, we employed Levine's epigenetic clock (DNAm PhenoAge) to estimate DNA…”
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Adverse Childhood Experiences are Associated with High-Intensity Binge Drinking Behavior in Adulthood and Mediated by Psychiatric Disorders by Jung, Jeesun, Rosoff, Daniel B, Muench, Christine, Luo, Audrey, Longley, Martha, Lee, Jisoo, Charlet, Katrin, Lohoff, Falk W

“…High-intensity binge drinking (HIBD), defined as two or more times the gender-specific binge threshold, is rapidly increasing in the USA; however, the…”
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Multi-Omics Mendelian Randomization Study Investigating the Impact of PCSK9 and HMGCR Inhibition on Type 2 Diabetes Across Five Populations by Rosoff, Daniel B, Wagner, Josephin, Jung, Jeesun, Pacher, Pal, Christodoulides, Constantinos, Smith, George Davey, Ray, David, Lohoff, Falk W

“…The prevalence of type 2 diabetes (T2D) varies among populations of different race/ethnicity. The influence of genetically-proxied lipoprotein cholesterol…”
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Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780,000 participants by Rosoff, Daniel B., Clarke, Toni-Kim, Adams, Mark J., McIntosh, Andrew M., Davey Smith, George, Jung, Jeesun, Lohoff, Falk W.

“…Observational studies suggest that lower educational attainment (EA) may be associated with risky alcohol use behaviors; however, these findings may be biased…”
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Imaging resilience and recovery in alcohol dependence by Charlet, Katrin, Rosenthal, Annika, Lohoff, Falk W., Heinz, Andreas, Beck, Anne

“…Background and aims Resilience and recovery are of increasing importance in the field of alcohol dependence (AD). This paper describes how imaging studies in…”
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Multi-omic underpinnings of epigenetic aging and human longevity by Mavromatis, Lucas A., Rosoff, Daniel B., Bell, Andrew S., Jung, Jeesun, Wagner, Josephin, Lohoff, Falk W.

“…Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs; however, its molecular mechanisms are poorly understood. Here, we use…”
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Targeting Oxidative Stress in Neurodegenerative Disorders: A Novel Role for PCSK9 Inhibition? by Park, Lauren M., Pacher, Pal, Lohoff, Falk W.

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein that regulates cholesterol levels by lysosomal low-density lipoprotein receptor (LDLR)…”
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