Search Results - "Lohoff, F. W."

Interaction between polymorphisms in serotonin transporter (SLC6A4) and serotonin receptor 2A (HTR2A) genes predict treatment response to venlafaxine XR in generalized anxiety disorder by Lohoff, F W, Narasimhan, S, Rickels, K

“…Variation in genes involved in serotonergic signaling is thought to be associated with antidepressant treatment response in generalized anxiety disorder (GAD)…”
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Case–control association analysis of polymorphisms in the delta-opioid receptor, OPRD1 , with cocaine and opioid addicted populations by Crist, R.C, Ambrose-Lanci, L.M, Vaswani, M, Clarke, T.K, Zeng, A, Yuan, C, Ferraro, T.N, Hakonarson, H, Kampman, K.M, Dackis, C.A, Pettinati, H.M, O’Brien, C.P, Oslin, D.W, Doyle, G.A, Lohoff, F.W, Berrettini, W.H

“…Abstract Background Addiction susceptibility and treatment responsiveness are greatly influenced by genetic factors. Sequence variation in genes involved in…”
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Functional genetic variants in the vesicular monoamine transporter 1 modulate emotion processing by Lohoff, F W, Hodge, R, Narasimhan, S, Nall, A, Ferraro, T N, Mickey, B J, Heitzeg, M M, Langenecker, S A, Zubieta, J-K, Bogdan, R, Nikolova, Y S, Drabant, E, Hariri, A R, Bevilacqua, L, Goldman, D, Doyle, G A

“…Emotional behavior is in part heritable and often disrupted in psychopathology. Identification of specific genetic variants that drive this heritability may…”
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Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction by Clarke, T.‐K., Ambrose‐Lanci, L., Ferraro, T. N., Berrettini, W. H., Kampman, K. M., Dackis, C. A., Pettinati, H. M., O’Brien, C. P., Oslin, D. W., Lohoff, F. W.

“…Genetic factors are believed to account for 30–50% of the risk for cocaine and heroin addiction. Dynorphin peptides, derived from the prodynorphin (PDYN)…”
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VMAT1 deletion causes neuronal loss in the hippocampus and neurocognitive deficits in spatial discrimination by Multani, P.K, Hodge, R, Estévez, M.A, Abel, T, Kung, H, Alter, M, Brookshire, B, Lucki, I, Nall, A.H, Talbot, K, Doyle, G.A, Lohoff, F.W

“…Highlights ► VMAT1 is expressed in mouse brain. ► Deletion of VMAT1 results in reduced neurogenesis and apoptosis in the hippocampus. ► VMAT2 expression is not…”
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Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility by Buono, R.J, Lohoff, F.W, Sander, T, Sperling, M.R, O’Connor, M.J, Dlugos, D.J, Ryan, S.G, Golden, G.T, Zhao, H, Scattergood, T.M, Berrettini, W.H, Ferraro, T.N

“…Purpose: Our research program uses genetic linkage and association analysis to identify human seizure sensitivity and resistance alleles. Quantitative trait…”
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Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder by Lohoff, F.W., Sander, T., Ferraro, T.N., Dahl, J.P., Gallinat, J., Berrettini, W.H.

“…Recent studies have indicated that the brain‐derived neurotrophic factor (BDNF) gene is involved in the etiology of bipolar disorder (BPD). Two family‐based…”
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Exome sequence analysis of Finnish patients with clozapine-induced agranulocytosis by Tiwari, A K, Need, A C, Lohoff, F W, Zai, C C, Chowdhury, N I, Müller, D J, Putkonen, A, Repo-Tiihonen, E, Hallikainen, T, Anil Yağcıoğlu, A E, Tiihonen, J, Kennedy, J L, Meltzer, H Y

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Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy by Lenzen, K.P., Heils, A., Lorenz, S., Hempelmann, A., Höfels, S., Lohoff, F.W., Schmitz, B., Sander, T.

“…Quantitative trait loci (QTL) mapping in mice revealed a seizure-related QTL ( Szs1), for which the inward-rectifying potassium channel Kcnj10 is the most…”
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Genetic dissection of intermale aggressive behavior in BALB/cJ and A/J mice by Dow, H. C., Kreibich, A. S., Kaercher, K. A., Sankoorikal, G. M. V., Pauley, E. D., Lohoff, F. W., Ferraro, T. N., Li, H., Brodkin, E. S.

“…Aggressive behaviors are disabling, treatment refractory, and sometimes lethal symptoms of several neuropsychiatric disorders. However, currently available…”
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Methylomic profiling and replication implicates deregulation of PCSK9 in alcohol use disorder by Lohoff, F W, Sorcher, J L, Rosen, A D, Mauro, K L, Fanelli, R R, Momenan, R, Hodgkinson, C A, Vendruscolo, L F, Koob, G F, Schwandt, M, George, D T, Jones, I S, Holmes, A, Zhou, Z, Xu, M-J, Gao, B, Sun, H, Phillips, M J, Muench, C, Kaminsky, Z A

“…Alcohol use disorder (AUD) is a common and chronic disorder with substantial effects on personal and public health. The underlying pathophysiology is poorly…”
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Confirmation of multiple seizure susceptibility QTLs on chromosome 15 in C57BL/6J and DBA/2J inbred mice by Ferraro, T N, Smith, G G, Schwebel, C L, Doyle, G A, Ruiz, S E, Oleynick, J U, Lohoff, F W, Berrettini, W H, Buono, R J

“…To confirm seizure susceptibility (SZS) quantitative trait loci (QTLs) on chromosome (chr) 15 identified previously using C57BL/6J (B6) and DBA/2J (D2) mice…”
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Serotonin receptor 2A (HTR2A) gene polymorphism predicts treatment response to venlafaxine XR in generalized anxiety disorder by Lohoff, F W, Aquino, T D, Narasimhan, S, Multani, P K, Etemad, B, Rickels, K

“…Generalized anxiety disorder (GAD) is a chronic psychiatric disorder with significant morbidity and mortality. Antidepressant drugs are the preferred choice…”
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Genetic variation in OPRD1 and the response to treatment for opioid dependence with buprenorphine in European-American females by Clarke, T-K, Crist, R C, Ang, A, Ambrose-Lanci, L M, Lohoff, F W, Saxon, A J, Ling, W, Hillhouse, M P, Bruce, R D, Woody, G, Berrettini, W H

“…Two commonly prescribed treatments for opioid addiction are methadone and buprenorphine. Although these drugs show some efficacy in treating opioid dependence,…”
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Quantitative trait loci for electrical seizure threshold mapped in C57BLKS/J and C57BL/10SnJ mice by Ferraro, T. N., Smith, G. G., Ballard, D., Zhao, H., Schwebel, C. L., Gupta, A., Rappaport, E. F., Ruiz, S. E., Lohoff, F. W., Doyle, G. A., Berrettini, W. H., Buono, R. J.

“…We mapped the quantitative trait loci (QTL) that contribute to the robust difference in maximal electroshock seizure threshold (MEST) between C57BLKS/J (BKS)…”
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Fine mapping of a seizure susceptibility locus on mouse Chromosome 1: nomination of Kcnj10 as a causative gene by Ferraro, Thomas N, Golden, Gregory T, Smith, George G, Martin, James F, Lohoff, Falk W, Gieringer, Tracy A, Zamboni, Deborah, Schwebel, Candice L, Press, Danielle M, Kratzer, Stephanie O, Zhao, Hongyu, Berrettini, Wade H, Buono, Russell J

“…Previous quantitative trait loci (QTL) mapping studies document that the distal region of mouse Chromosome (Chr) 1 contains a gene(s) that is in large part…”
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Lack of Association Between an Interleukin 1 Beta (IL‐1β) Gene Variation and Refractory Temporal Lobe Epilepsy by Buono, Russell J., Ferraro, Thomas N., O'Connor, Michael J., Sperling, Michael R., Ryan, Stephen G., Scattergood, Theresa, Mulholland, Nicole, Gilmore, Joan, Lohoff, Falk W., Berrettini, Wade H.

“…Purpose: We attempted to confirm recent findings of Kanemoto et al. that demonstrated a positive association (p < 0.017) between a polymorphism in the promoter…”
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Quantitative Genetic Study of Maximal Electroshock Seizure Threshold in Mice: Evidence for a Major Seizure Susceptibility Locus on Distal Chromosome 1 by Ferraro, Thomas N., Golden, Gregory T., Smith, George G., Longman, Ryan L., Snyder, Robert L., DeMuth, Denis, Szpilzak, Ivanna, Mulholland, Nicole, Eng, Elaine, Lohoff, Falk W., Buono, Russell J., Berrettini, Wade H.

“…We conducted a quantitative trait locus (QTL) mapping study to dissect the multifactorial nature of maximal electroshock seizure threshold (MEST) in C57BL/6…”
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Genetic variants in the vesicular monoamine transporter 1 (VMAT1/SLC18A1) and neuropsychiatric disorders by Lohoff, Falk W

“…Vesicular monoamine transporters (VMATs) are involved in the presynaptic packaging of monoaminergic neurotransmitters into storage granules. Upon an action…”
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Ziprasidone Treatment of Refractory Generalized Anxiety Disorder: A Placebo-Controlled, Double-Blind Study by LOHOFF, Falk W, ETEMAD, Bijan, MANDOS, Laura A, GALLOP, Robert, RICKELS, Karl

“…This 8-week, randomized, double-blind, placebo-controlled, flexible-dose trial assessed the efficacy, safety, and tolerability of ziprasidone in adults with…”
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