Search Results - "Lohman, RJ"

Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110) by Suen, JY, Barry, GD, Lohman, RJ, Halili, MA, Cotterell, AJ, Le, GT, Fairlie, DP

“…BACKGROUND AND PURPOSE Many cells express proteinase activated receptor 2 (PAR2) on their plasma membrane. PAR2 is activated by proteolytic enzymes, such as…”
Get full text

Pathway‐selective antagonism of proteinase activated receptor 2 by Suen, J Y, Cotterell, A, Lohman, R J, Lim, J, Han, A, Yau, M K, Liu, L, Cooper, M A, Vesey, D A, Fairlie, D P

“…Background and Purpose Proteinase activated receptor 2 (PAR2) is a GPCR associated with inflammation, metabolism and disease. Clues to understanding how to…”
Get full text

Novel Helix-Constrained Nociceptin Derivatives Are Potent Agonists and Antagonists of ERK Phosphorylation and Thermal Analgesia in Mice by Harrison, Rosemary S, Ruiz-Gómez, Gloria, Hill, Timothy A, Chow, Shiao Y, Shepherd, Nicholas E, Lohman, Rink-Jan, Abbenante, Giovanni, Hoang, Huy N, Fairlie, David P

“…The nociceptin opioid peptide receptor (NOP, NOR, ORL-1) is a GPCR that recognizes nociceptin, a 17-residue peptide hormone. Nociceptin regulates pain…”
Get full text

Validation of a method for localised microinjection of drugs into thalamic subregions in rats for epilepsy pharmacological studies by Lohman, Rink-Jan, Liu, Lige, Morris, Margaret, O’Brien, Terence J.

“…To validate a method for the chronic implantation of micro-cannulae to examine the effect of drug administration to two small brain regions critical to the…”
Get full text

Action potential afterdepolarization mediated by a Ca2+-activated cation conductance in myenteric AH neurons by Vogalis, F, Harvey, J R, Lohman, R-J, Furness, J B

“…We investigated the nature of afterdepolarizing potentials in AH neurons from the guinea-pig duodenum using whole-cell patch-clamp recordings in intact…”
Get full text