Search Results - "Lohith, G."

Data integration: Combined imaging and electrophysiology data in the cloud by Kini, Lohith G., Davis, Kathryn A., Wagenaar, Joost B.

“…There has been an increasing effort to correlate electrophysiology data with imaging in patients with refractory epilepsy over recent years. IEEG.org provides…”
Get full text

Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery by Pipal, Robert W., Stout, Kenneth T., Musacchio, Patricia Z., Ren, Sumei, Graham, Thomas J. A., Verhoog, Stefan, Gantert, Liza, Lohith, Talakad G., Schmitz, Alexander, Lee, Hsiaoju S., Hesk, David, Hostetler, Eric D., Davies, Ian W., MacMillan, David W. C.

“…Positron emission tomography (PET) radioligands (radioactively labelled tracer compounds) are extremely useful for in vivo characterization of central nervous…”
Get full text

Virtual resection predicts surgical outcome for drug-resistant epilepsy by Kini, Lohith G, Bernabei, John M, Mikhail, Fadi, Hadar, Peter, Shah, Preya, Khambhati, Ankit N, Oechsel, Kelly, Archer, Ryan, Boccanfuso, Jacqueline, Conrad, Erin, Shinohara, Russell T, Stein, Joel M, Das, Sandhitsu, Kheder, Ammar, Lucas, Timothy H, Davis, Kathryn A, Bassett, Danielle S, Litt, Brian

“…Patients with drug-resistant epilepsy often require surgery to become seizure-free. While laser ablation and implantable stimulation devices have lowered the…”
Get full text

Computational analysis in epilepsy neuroimaging: A survey of features and methods by Kini, Lohith G, Gee, James C, Litt, Brian

“…Epilepsy affects 65 million people worldwide, a third of whom have seizures that are resistant to anti-epileptic medications. Some of these patients may be…”
Get full text

Discovery of 6‑(Fluoro-18 F)‑3-(1H‑pyrrolo[2,3‑c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs) by Walji, Abbas M, Hostetler, Eric D, Selnick, Harold, Zeng, Zhizhen, Miller, Patricia, Bennacef, Idriss, Salinas, Cristian, Connolly, Brett, Gantert, Liza, Holahan, Marie, O’Malley, Stacey, Purcell, Mona, Riffel, Kerry, Li, Jing, Balsells, Jaume, OBrien, Julie A, Melquist, Stacey, Soriano, Aileen, Zhang, Xiaoping, Ogawa, Aimie, Xu, Serena, Joshi, Elizabeth, Della Rocca, Joseph, Hess, Fred J, Schachter, Joel, Hesk, David, Schenk, David, Struyk, Arie, Babaoglu, Kerim, Lohith, Talakad G, Wang, Yaode, Yang, Kun, Fu, Jianmin, Evelhoch, Jeffrey L, Coleman, Paul J

“…Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases…”
Get full text

Quantitative [18]FDG PET asymmetry features predict long-term seizure recurrence in refractory epilepsy by Kini, Lohith G., Thaker, Ashesh A., Hadar, Peter N., Shinohara, Russell T., Brown, Mesha-Gay, Dubroff, Jacob G., Davis, Kathryn A.

“…•Quantitative FDG-PET measures can augment clinical variables in predicting seizure recurrence in drug-resistant temporal lobe epilepsy patients.•Computed…”
Get full text

Association of Piriform Cortex Resection With Surgical Outcomes in Patients With Temporal Lobe Epilepsy by Galovic, Marian, Baudracco, Irene, Wright-Goff, Evan, Pillajo, Galo, Nachev, Parashkev, Wandschneider, Britta, Woermann, Friedrich, Thompson, Pamela, Baxendale, Sallie, McEvoy, Andrew W, Nowell, Mark, Mancini, Matteo, Vos, Sjoerd B, Winston, Gavin P, Sparks, Rachel, Prados, Ferran, Miserocchi, Anna, de Tisi, Jane, Van Graan, Louis André, Rodionov, Roman, Wu, Chengyuan, Alizadeh, Mahdi, Kozlowski, Lauren, Sharan, Ashwini D, Kini, Lohith G, Davis, Kathryn A, Litt, Brian, Ourselin, Sebastien, Moshé, Solomon L, Sander, Josemir W A, Löscher, Wolfgang, Duncan, John S, Koepp, Matthias J

“…A functional area associated with the piriform cortex, termed area tempestas, has been implicated in animal studies as having a crucial role in modulating…”
Get more information

Gold fiducial tracking using CyberKnife in adrenal metastasis from small cell lung cancers by Lohith, G., Ajai Kumar, B.S.

Get full text

Radiosynthesis and Early Evaluation of a Positron Emission Tomography Imaging Probe [18F]AGAL Targeting Alpha-Galactosidase A Enzyme for Fabry Disease by Lohith, Talakad G., Kaittanis, Charalambos, Belanger, Anthony P., Ahn, Shin Hye, Sandoval, Phil, Cohen, Lawrence, Rajarshi, Girija, Ruangsiriluk, Wanida, Islam, Rizwana, Winkelmann, Christopher T., McQuade, Paul

“…Success of gene therapy relies on the durable expression and activity of transgene in target tissues. In vivo molecular imaging approaches using positron…”
Get full text

Cerebral metabolic rate of oxygen in obstructive sleep apnea at rest and in response to breath-hold challenge by Rodgers, Zachary B, Leinwand, Sarah E, Keenan, Brendan T, Kini, Lohith G, Schwab, Richard J, Wehrli, Felix W

“…Obstructive sleep apnea (OSA) is associated with extensive neurologic comorbidities. It is hypothesized that the repeated nocturnal apneas experienced in…”
Get full text

High interictal connectivity within the resection zone is associated with favorable post-surgical outcomes in focal epilepsy patients by Shah, Preya, Bernabei, John M, Kini, Lohith G, Ashourvan, Arian, Boccanfuso, Jacqueline, Archer, Ryan, Oechsel, Kelly, Das, Sandhitsu R, Stein, Joel M, Lucas, Timothy H, Bassett, Danielle S, Davis, Kathryn A, Litt, Brian

“…Patients with drug-resistant focal epilepsy are often candidates for invasive surgical therapies. In these patients, it is necessary to accurately localize…”
Get full text

Comparison of two PET radioligands, [11C]FPEB and [11C]SP203, for quantification of metabotropic glutamate receptor 5 in human brain by Lohith, Talakad G, Tsujikawa, Tetsuya, Siméon, Fabrice G, Veronese, Mattia, Zoghbi, Sami S, Lyoo, Chul Hyoung, Kimura, Yasuyuki, Morse, Cheryl L, Pike, Victor W, Fujita, Masahiro, Innis, Robert B

“…Of the two 18F-labeled PET ligands currently available to image metabotropic glutamate receptor 5 (mGluR5), [18F]FPEB is reportedly superior because [18F]SP203…”
Get full text

Volumetric glutamate imaging (GluCEST) using 7T MRI can lateralize nonlesional temporal lobe epilepsy: A preliminary study by Hadar, Peter N., Kini, Lohith G., Nanga, Ravi Prakash Reddy, Shinohara, Russell T., Chen, Stephanie H., Shah, Preya, Wisse, Laura E. M., Elliott, Mark A., Hariharan, Hari, Reddy, Ravinder, Detre, John A., Stein, Joel M., Das, Sandhitsu, Davis, Kathryn A.

“…Introduction Drug‐resistant epilepsy patients show worse outcomes after resection when standard neuroimaging is nonlesional, which occurs in one‐third of…”
Get full text

Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles by Koole, Michel, Lohith, Talakad G., Valentine, John L., Bennacef, Idriss, Declercq, Ruben, Reynders, Tom, Riffel, Kerry, Celen, Sofie, Serdons, Kim, Bormans, Guy, Ferry-Martin, Sandrine, Laroque, Philippe, Walji, Abbas, Hostetler, Eric D., Briscoe, Richard J., de Hoon, Jan, Sur, Cyrille, Van Laere, Koen, Struyk, Arie

“…Purpose [ 18 F]MK-6240 is a selective, high-affinity positron emission tomography tracer for imaging neurofibrillary tangles, a key pathological signature that…”
Get full text

A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [18F]MK-6240 by Kolinger, Guilherme D., Vállez García, David, Lohith, Talakad G., Hostetler, Eric D., Sur, Cyrille, Struyk, Arie, Boellaard, Ronald, Koole, Michel

“…Background [ 18 F]MK-6240 is a PET tracer with sub-nanomolar affinity for neurofibrillary tangles. Therefore, tau quantification is possible with [ 18…”
Get full text

Remote effects of temporal lobe epilepsy surgery: Long‐term morphological changes after surgical resection by Arnold, T. Campbell, Kini, Lohith G., Bernabei, John M., Revell, Andrew Y., Das, Sandhitsu R., Stein, Joel M., Lucas, Timothy H., Englot, Dario J., Morgan, Victoria L., Litt, Brian, Davis, Kathryn A.

“…Objective Epilepsy surgery is an effective treatment for drug‐resistant patients. However, how different surgical approaches affect long‐term brain structure…”
Get full text

Clinical validation of automated hippocampal segmentation in temporal lobe epilepsy by Hadar, Peter N., Kini, Lohith G., Coto, Carlos, Piskin, Virginie, Callans, Lauren E., Chen, Stephanie H., Stein, Joel M., Das, Sandhitsu R., Yushkevich, Paul A., Davis, Kathryn A.

“…To provide a multi-atlas framework for automated hippocampus segmentation in temporal lobe epilepsy (TLE) and clinically validate the results with respect to…”
Get full text

Electrocorticography and stereo EEG provide distinct measures of brain connectivity: implications for network models by Bernabei, John M, Arnold, T Campbell, Shah, Preya, Revell, Andrew, Ong, Ian Z, Kini, Lohith G, Stein, Joel M, Shinohara, Russell T, Lucas, Timothy H, Davis, Kathryn A, Bassett, Danielle S, Litt, Brian

“…Abstract Brain network models derived from graph theory have the potential to guide functional neurosurgery, and to improve rates of post-operative seizure…”
Get full text

11C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain by Ikawa, Masamichi, Lohith, Talakad G, Shrestha, Stal, Telu, Sanjay, Zoghbi, Sami S, Castellano, Sabrina, Taliani, Sabrina, Da Settimo, Federico, Fujita, Masahiro, Pike, Victor W, Innis, Robert B

“…For PET imaging of 18-kDa translocator protein (TSPO), a biomarker of neuroinflammation, most second-generation radioligands are sensitive to the single…”
Get full text

Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome? by Lohith, Talakad G, Osterweil, Emily K, Fujita, Masahiro, Jenko, Kimberly J, Bear, Mark F, Innis, Robert B

“…Fragile X syndrome (FXS) is a common inherited form of intellectual disability caused by loss of function of the fragile X mental retardation protein. Recent…”
Get full text