Search Results - "Lohan, Sandeep"

Combination of Amphiphilic Cyclic Peptide [R 4 W 4 ] and Levofloxacin against Multidrug-Resistant Bacteria by Sajid, Muhammad Imran, Lohan, Sandeep, Kato, Shun, Tiwari, Rakesh Kumar

“…Bacterial resistance is a growing global concern necessitating the discovery and development of antibiotics effective against the drug-resistant bacterial…”
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Oleyl Conjugated Histidine-Arginine Cell-Penetrating Peptides as Promising Agents for siRNA Delivery by Sajid, Muhammad Imran, Mandal, Dindyal, El-Sayed, Naglaa Salem, Lohan, Sandeep, Moreno, Jonathan, Tiwari, Rakesh Kumar

“…Recent approvals of siRNA-based products motivated the scientific community to explore siRNA as a treatment option for several intractable ailments, especially…”
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Modified Linear Peptides Effectively Silence STAT-3 in Breast Cancer and Ovarian Cancer Cell Lines by Mandal, Dindyal, Lohan, Sandeep, Sajid, Muhammad Imran, Alhazza, Abdulelah, Tiwari, Rakesh Kumar, Parang, Keykavous, Montazeri Aliabadi, Hamidreza

“…RNA interference (RNAi) has drawn enormous attention as a powerful tool because of its capability to interfere with mRNA and protein production. However,…”
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Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Agents by Salehi, David, Mozaffari, Saghar, Zoghebi, Khalid, Lohan, Sandeep, Mandal, Dindyal, Tiwari, Rakesh K, Parang, Keykavous

“…A series of cyclic peptides, [(DipR)(WR) ], [(DipR) (WR) ], [(DipR) (WR) ], [(DipR) (WR)], and [DipR] , and their linear counterparts containing arginine (R)…”
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Recent approaches in design of peptidomimetics for antimicrobial drug discovery research by Lohan, Sandeep, Bisht, Gopal Singh

“…Resistant pathogenic microbial strains are emerging at a rate that far exceeds the pace of new anti-infective drug development. In order to combat resistance…”
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Small cationic antimicrobial peptidomimetics: emerging candidate for the development of potential anti-infective agents by Lohan, Sandeep, Bisht, Gopal Singh

“…Rapid increase in the emergence and spread of microbes resistant to conventionally used antibiotics has become a major threat to global health care…”
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Cyclic Peptide-Gadolinium Nanocomplexes as siRNA Delivery Tools by Nasrolahi Shirazi, Amir, Sajid, Muhammad Imran, Mandal, Dindyal, Stickley, David, Nagasawa, Stephanie, Long, Joshua, Lohan, Sandeep, Parang, Keykavous, Tiwari, Rakesh Kumar

“…We have recently reported that a cyclic peptide containing five tryptophan, five arginine, and one cysteine amino acids [(WR)5C], was able to produce…”
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Cyclic Peptide-Gadolinium Nanoparticles for Enhanced Intracellular Delivery by Shirazi, Amir Nasrolahi, Park, Shang Eun, Rad, Shirin, Baloyan, Luiza, Mandal, Dindyal, Sajid, Muhammad Imran, Hall, Ryley, Lohan, Sandeep, Zoghebi, Khalid, Parang, Keykavous, Tiwari, Rakesh Kumar

“…A cyclic peptide containing one cysteine and five alternating tryptophan and arginine amino acids [(WR)5C] was synthesized using Fmoc/tBu solid-phase…”
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Modifying peptide/lipid-associated nucleic acids (PLANAs) for CRISPR/Cas9 ribonucleoprotein delivery by Alhazza, Abdulelah, Mahdipoor, Parvin, Hall, Ryley, Manda, Arthur, Lohan, Sandeep, Parang, Keykavous, Aliabadi, Hamidreza Montazeri

“…With the first reports on the possibility of genome editing by Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated protein…”
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Cyclic and Linear Peptides Containing Alternate WW and RR Residues as Molecular Cargo Delivery Tools by Kim, Lois, Lohan, Sandeep, Moreno, Jonathan, Zoghebi, Khalid, Tiwari, Rakesh Kumar, Parang, Keykavous

“…Cell-impermeable and negatively charged compounds’ cellular uptake across the cell membranes remains challenging. Herein, the synthesis of four linear…”
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Tea: A native source of antimicrobial agents by Bansal, Sumit, Choudhary, Shivani, Sharma, Manu, Kumar, Suthar Sharad, Lohan, Sandeep, Bhardwaj, Varun, Syan, Navneet, Jyoti, Saras

“…Tea (Camellia sinensis) is one of the most popular nonalcoholic beverages, consumed by over two-thirds of the world's population because of its refreshing,…”
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Targeted Delivery of Cabazitaxel Using Cyclic Cell-Penetrating Peptide and Biomarkers of Extracellular Matrix for Prostate and Breast Cancer Therapy by Park, Shang Eun, El-Sayed, Naglaa Salem, Shamloo, Kiumars, Lohan, Sandeep, Kumar, Sumit, Sajid, Muhammad Imran, Tiwari, Rakesh Kumar

“…Targeted drug delivery for cancer therapy is an emerging area of research. Cancer cells overexpress certain biomarkers that can be exploited for their targeted…”
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Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics by Mohammed, Eman H. M., Lohan, Sandeep, Ghaffari, Tarra, Gupta, Shilpi, Tiwari, Rakesh K., Parang, Keykavous

“…We designed a library of 24 cyclic peptides containing arginine (R) and tryptophan (W) residues in a sequential manner [R n W n ] (n = 2–7) to study the impact…”
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Quinoxaline-PABA bipartite hybrid derivatization approach: Design and search for antimicrobial agents by Patel, Harun M., Bhardwaj, Varun, Sharma, Poonam, Noolvi, Malleshappa N., Lohan, Sandeep, Bansal, Sumit, Sharma, Amit

“…In an attempt to find a new class of antimicrobial agents, in the present study we report the synthesis of bipartite hybrid styryl derivatives of quinoxaline…”
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Structure-Based Rational Design of Small α‑Helical Peptides with Broad-Spectrum Activity against Multidrug-Resistant Pathogens by Lohan, Sandeep, Konshina, Anastasia G., Efremov, Roman G., Maslennikov, Innokentiy, Parang, Keykavous

“…A series of small (7–12 mer) amphipathic cationic peptides were designed and synthesized to create short helical peptides with broad-range bactericidal…”
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siRNA Therapeutics for the Therapy of COVID-19 and Other Coronaviruses by Sajid, Muhammad Imran, Moazzam, Muhammad, Cho, Yeseom, Kato, Shun, Xu, Ava, Way, J. J., Lohan, Sandeep, Tiwari, Rakesh K.

“…The ongoing pandemic of global concern has killed about three million humans and affected around 151 million people worldwide, as of April 30, 2021. Although…”
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Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties by Lohan, Sandeep, Mandal, Dindyal, Choi, Wonsuk, Konshina, Anastasia G, Tiwari, Rakesh K, Efremov, Roman G, Maslennikov, Innokentiy, Parang, Keykavous

“…We report the synthesis and antibacterial activities of a series of amphiphilic membrane-active peptides composed, in part, of various nongenetically coded…”
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Amphiphilic cyclic peptide [W4KR5]-Antibiotics combinations as broad-spectrum antimicrobial agents by Mohammed, Eman H.M., Lohan, Sandeep, Tiwari, Rakesh K., Parang, Keykavous

“…Linear and cyclic amphiphilic peptides, (W4KR5) and [W4KR5], were evaluated as antibacterial agents against Gram-positive and Gram-negative bacteria, including…”
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Broad-spectrum activity of membranolytic cationic macrocyclic peptides against multi-drug resistant bacteria and fungi by Lohan, Sandeep, Konshina, Anastasia G., Tiwari, Rakesh K., Efremov, Roman G., Maslennikov, Innokentiy, Parang, Keykavous

“…•A series of cyclic peptides composed of non-canonical amino acids were synthesized and characterized.•Peptides displayed broad-spectrum activity against…”
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Novel quinolone substituted thiazolidin-4-ones as anti-inflammatory, anticancer agents: Design, synthesis and biological screening by Suthar, Sharad Kumar, Jaiswal, Varun, Lohan, Sandeep, Bansal, Sumit, Chaudhary, Anil, Tiwari, Amit, Alex, Angel Treasa, Joesph, Alex

“…Nuclear factor-kappaB (NF-κB) has been reported to regulate various genes involved in cancer and inflammation. Accordingly, drugs suppressing or inhibiting…”
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