Search Results - "Loh, Jia Tong"

Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection by Wang, Xiaohui, Lin, Xiang, Zheng, Zihan, Lu, Bingtai, Wang, Jun, Tan, Andy Hee-Meng, Zhao, Meng, Loh, Jia Tong, Ng, Sze Wai, Chen, Qian, Xiao, Fan, Huang, Enyu, Ko, King-Hung, Huang, Zhong, Li, Jingyi, Kok, Kin-Hang, Lu, Gen, Liu, Xiaohui, Lam, Kong-Peng, Liu, Wanli, Zhang, Yuxia, Yuen, Kwok-Yung, Mak, Tak Wah, Lu, Liwei

“…Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids…”
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DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils by Loh, Jia Tong, Lee, Koon-Guan, Lee, Alison P., Teo, Joey Kay Hui, Lim, Hsueh Lee, Kim, Susana Soo-Yeon, Tan, Andy Hee-Meng, Lam, Kong-Peng

“…How pathogenesis of inflammatory bowel disease (IBD) depends on the complex interplay of host genetics, microbiome and the immune system is not fully…”
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The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin by Gunawan, Merry, Venkatesan, Nandini, Loh, Jia Tong, Wong, Jong Fu, Berger, Heidi, Neo, Wen Hao, Li, Liang Yao Jackson, La Win, Myint Khun, Yau, Yin Hoe, Guo, Tiannan, See, Peter Chi Ee, Yamazaki, Sayuri, Chin, Keh Chuang, Gingras, Alexandre R, Shochat, Susana Geifman, Ng, Lai Guan, Sze, Siu Kwan, Ginhoux, Florent, Su, I-hsin

“…Ezh2 is a protein methylase that epigenetically modifies chromatin. Su and colleagues identify a cytoplasmic role for Ezh2 whereby it controls the…”
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Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein by Loh, Jia Tong, Teo, Joey Kay Hui, Lam, Kong-Peng

“…Increased neutrophils and elevated level of circulating calprotectin are hallmarks of severe COVID-19 and they contribute to the dysregulated immune responses…”
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Mesenchymal Stromal Cell Exosomes Mediate M2-like Macrophage Polarization through CD73/Ecto-5'-Nucleotidase Activity by Teo, Kristeen Ye Wen, Zhang, Shipin, Loh, Jia Tong, Lai, Ruenn Chai, Hey, Hwee Weng Dennis, Lam, Kong-Peng, Lim, Sai Kiang, Toh, Wei Seong

“…Mesenchymal stem/stromal cell (MSC) exosomes have been shown to alleviate immune dysfunction and inflammation in preclinical animal models. This therapeutic…”
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Emerging Roles of Downstream of Kinase 3 in Cell Signaling by Loh, Jia Tong, Teo, Joey Kay Hui, Lim, Hong-Hwa, Lam, Kong-Peng

“…Downstream of kinase (Dok) 3 is a member of the Dok family of adaptor proteins known to regulate signaling pathways downstream of various immunoreceptors. As…”
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Post-translational modification-regulated leukocyte adhesion and migration by Loh, Jia Tong, Su, I-Hsin

“…Leukocytes undergo frequent phenotypic changes and rapidly infiltrate peripheral and lymphoid tissues in order to carry out immune responses. The recruitment…”
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Disrupting the Dok3-Card9 Interaction with Synthetic Peptides Enhances Antifungal Effector Functions of Human Neutrophils by Loh, Jia Tong, Teo, Joey Kay Hui, Kannan, Srinivasaraghavan, Verma, Chandra S, Lim, Hong-Hwa, Lam, Kong-Peng

“…Invasive fungal disease is an emerging and serious public health threat globally. The expanding population of susceptible individuals, together with the rapid…”
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Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells by Loh, Jia Tong, Lim, Thomas Jun Feng, Ikumi, Kyoko, Matoba, Takuma, Janela, Baptiste, Gunawan, Merry, Toyama, Tatsuya, Bunjamin, Maegan, Ng, Lai Guan, Poidinger, Michael, Morita, Akimichi, Ginhoux, Florent, Yamazaki, Sayuri, Lam, Kong-Peng, Su, I-Hsin

“…Ezh2, a well-established epigenetic repressor, can down-regulate leukocyte inflammatory responses, but its role in cutaneous health remains elusive. Here we…”
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Fungal infections: Immune defense, immunotherapies and vaccines by Loh, Jia Tong, Lam, Kong-Peng

“…[Display omitted] Invasive fungal infection is an under recognized and emerging global health threat. Recently, the World Health Organization (WHO) released…”
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Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes by Loh, Jia Tong, Zhang, Bin, Teo, Joey Kay Hui, Lai, Ruenn Chai, Choo, Andre Boon Hwa, Lam, Kong-Peng, Lim, Sai Kiang

“…Complements and neutrophils are two key players of the innate immune system that are widely implicated as drivers of severe COVID-19 pathogenesis, as evident…”
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Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity by Loh, Jia Tong, Xu, Shengli, Huo, Jian Xin, Kim, Susana Soo-Yeon, Wang, Yue, Lam, Kong-Peng

“…Invasive fungal infection is a serious health threat with high morbidity and mortality. Current antifungal drugs only demonstrate partial success in improving…”
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Neutrophils in the Pathogenesis of Rheumatic Diseases by Loh, Jia Tong, Lam, Kong-Peng

“…Rheumatic diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and anti-neutrophil cytoplasmic antibody (ANCA)-associated…”
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DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11 by Loh, Jia Tong, Teo, Joey Kay Hui, Kannan, Srinivasaraghavan, Verma, Chandra S, Andiappan, Anand Kumar, Lim, Hong-Hwa, Lam, Kong-Peng

“…The scaffolding protein CARD11 is a critical mediator of antigen receptor signaling in lymphocytes. Hypomorphic (partial loss-of-function) mutations in CARD11…”
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Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution by Chung, Hwa Hwa, Or, Yu Zuan, Shrestha, Smeeta, Loh, Jia Tong, Lim, Chew Leng, Ong, Zoe, Woo, Amanda Rui En, Su, I-Hsin, Lin, Valerie C. L.

“…Epidemiological studies have indicated increased risk for breast cancer within 10 years of childbirth. Acute inflammation during mammary involution has been…”
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