Search Results - "Loh, Jacelyn M.S."

Generation of Bioluminescent Group A Streptococcus for Biophotonic Imaging by Loh, Jacelyn M S, Soh, Kar Yan, Proft, Thomas

“…Bioluminescence is a rapid and cost-saving technology that enables monitoring of bacteria in real time in animal infection models. Here, we report a method for…”
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Complement evasion factor (CEF), a novel immune evasion factor of Streptococcus pyogenes by Aghababa, Haniyeh, Ting, Yi Tian, Pilapitiya, Devaki, Loh, Jacelyn M.S., Young, Paul G., Proft, Thomas

“…Streptococcus pyogenes, a leading human pathogen, is responsible for a wide range of diseases, including skin and soft tissue infections and severe invasive…”
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The Use of Galleria mellonella (Wax Moth) as an Infection Model for Group A Streptococcus by Tsai, Catherine Jia-Yun, Loh, Jacelyn M S, Proft, Thomas

“…Recently, the use of Galleria mellonella larvae as a nonmammalian model to simulate bacterial infectious diseases has shown to be a rapid, simple, and…”
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Identification of an immunodominant region on a group A Streptococcus T-antigen reveals temperature-dependent motion in pili by Raynes, Jeremy M., Young, Paul G., Lorenz, Natalie, Loh, Jacelyn M.S., McGregor, Reuben, Baker, Edward N., Proft, Thomas, Moreland, Nicole J.

“…Group A Streptococcus (GAS) is a globally important pathogen causing a broad range of human diseases. GAS pili are elongated proteins with a backbone comprised…”
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Using Lactococcus lactis as Surrogate Organism to Study Group A Streptococcus Surface Proteins by Tsai, Catherine Jia-Yun, Loh, Jacelyn M S, Blanchett, Sam, Proft, Thomas

“…The isolation of a single Group A Streptococcus (GAS) virulence determinant in functional investigations is challenging, as GAS employs a multitude of…”
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Assays to Analyze Adhesion of Group A Streptococcus to Host Cells by Khemlani, Adrina H J, Proft, Thomas, Loh, Jacelyn M S

“…The critical first step of Group A Streptococcus (GAS) pathogenesis is adhesion to the host pharyngeal and skin epithelial cell surfaces (Brouwer et al., FEBS…”
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A Mouse Nasopharyngeal Colonization Model for Group A Streptococcus by Khemlani, Adrina H J, Proft, Thomas, Loh, Jacelyn M S

“…Group A Streptococcus (GAS) often exists as an asymptomatic colonizer of the upper respiratory tract in humans. Unsurprisingly, a high proportion of…”
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PilVax – a novel peptide delivery platform for the development of mucosal vaccines by Wagachchi, Dasun, Tsai, Jia-Yun C., Chalmers, Callum, Blanchett, Sam, Loh, Jacelyn M. S., Proft, Thomas

“…Peptide vaccines are an attractive strategy to engineer the induction of highly targeted immune responses and avoid potentially allergenic and/or reactogenic…”
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Toxin–antitoxin-stabilized reporter plasmids for biophotonic imaging of Group A streptococcus by Loh, Jacelyn M. S, Proft, Thomas

“…Bioluminescence is a rapid and cost-efficient optical imaging technology that allows the detection of bacteria in real-time during disease development. Here,…”
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Comparison of firefly luciferase and NanoLuc luciferase for biophotonic labeling of group A Streptococcus by Loh, Jacelyn M. S, Proft, Thomas

“…NanoLuc luciferase (Nluc) is an engineered enzyme that catalyses the substrate, furimazine, to produce light. Nluc has higher sensitivity than the commonly…”
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Gold kiwifruit (Actinidia chinensis ‘Hort16A’) for immune support by Skinner, Margot A., Loh, Jacelyn M. S., Hunter, Denise C., Zhang, Jingli

“…Kiwifruit is a good source of several vitamins and minerals and dietary fibre, and contains a number of phytochemicals; so kiwifruit potentially provides…”
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Methods to Analyze the Contribution of Complement Evasion Factor (CEF) to Streptococcus pyogenes Virulence by Aghababa, Haniyeh, Loh, Jacelyn M S, Proft, Thomas

“…Group A Streptococcus (GAS, Streptococcus pyogenes) is an exclusively human pathogen that causes a range of diseases, including pharyngitis, tonsillitis,…”
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Cell wall‐anchored 5′‐nucleotidases in Gram‐positive cocci by Soh, Kar Yan, Loh, Jacelyn M. S., Proft, Thomas

“…5′‐nucleotidases (5′‐NTs) are enzymes that catalyze the hydrolysis of nucleoside monophosphates to produce nucleosides and phosphate. Since the identification…”
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Mucosal vaccination: onward and upward by Tsai, Catherine J. Y., Loh, Jacelyn M. S., Fujihashi, Kohtaro, Kiyono, Hiroshi

“…INTRODUCTIONThe unique mucosal immune system allows the generation of robust protective immune responses at the front line of pathogen encounters. The…”
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Galleria mellonella larvae as an infection model for group A streptococcus by Loh, Jacelyn MS, Adenwalla, Nazneen, Wiles, Siouxsie, Proft, Thomas

“…Group A streptococcus is a strict human pathogen that can cause a wide range of diseases, such as tonsillitis, impetigo, necrotizing fasciitis, toxic shock,…”
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PilVax: A Novel Platform for the Development of Mucosal Vaccines by Tsai, Catherine Jia-Yun, Loh, Jacelyn M S, Proft, Thomas

“…Peptide vaccines offer an attractive strategy to induce highly specific immune responses while reducing potential side effects. However, peptides are often…”
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Streptococcal 5′-Nucleotidase A (S5nA), a Novel Streptococcus pyogenes Virulence Factor That Facilitates Immune Evasion by Zheng, Lisa, Khemlani, Adrina, Lorenz, Natalie, Loh, Jacelyn M.S., Langley, Ries J., Proft, Thomas

“…Streptococcus pyogenes is an important human pathogen that causes a wide range of diseases. Using bioinformatics analysis of the complete S. pyogenes strain…”
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Development of an opsonophagocytic killing assay for group a streptococcus by Jones, Scott, Moreland, Nicole J., Zancolli, Marta, Raynes, Jeremy, Loh, Jacelyn M.S., Smeesters, Pierre R., Sriskandan, Shiranee, Carapetis, Jonathan R., Fraser, John D., Goldblatt, David

“…•OPKA developed for a number of clinically relevant Group A Streptococcus.•Homologous M-protein antisera shown to kill GAS emm-types 1, 6 and 12.•Killing…”
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A multivalent T-antigen-based vaccine for Group A Streptococcus by Loh, Jacelyn M. S., Rivera-Hernandez, Tania, McGregor, Reuben, Khemlani, Adrina Hema J., Tay, Mei Lin, Cork, Amanda J., M. Raynes, Jeremy, Moreland, Nicole J., Walker, Mark J., Proft, Thomas

“…Pili of Group A Streptococcus (GAS) are surface-exposed structures involved in adhesion and colonisation of the host during infection. The major protein…”
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The effects of sugar in drinking water on Streptococcus pyogenes colonisation in a murine nasopharyngeal infection model by Hashimi, Farina Nor, Bennett, Julie, Baker, Michael G., Moreland, Nicole J., Merry, Troy L., Loh, Jacelyn M. S.

“…The number of sugar-sweetened beverages consumed per day has been associated with an increased risk of acute rheumatic fever, an autoimmune disease triggered…”
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