Search Results - "Loh, H H"
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Observation of the fastest chemical processes in the radiolysis of water
Published in Science (American Association for the Advancement of Science) (10-01-2020)“…Elementary processes associated with ionization of liquid water provide a framework for understanding radiation-matter interactions in chemistry and biology…”
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2
A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue
Published in Nature (London) (30-07-2020)“…Mutations in the leptin gene ( ob ) result in a metabolic disorder that includes severe obesity 1 , and defects in thermogenesis 2 and lipolysis 3 , both of…”
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3
Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids
Published in Cell (14-10-2011)“…Spinal opioid-induced itch, a prevalent side effect of pain management, has been proposed to result from pain inhibition. We now report that the μ-opioid…”
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4
Ecology of zoonoses: natural and unnatural histories
Published in The Lancet (British edition) (01-12-2012)“…Summary More than 60% of human infectious diseases are caused by pathogens shared with wild or domestic animals. Zoonotic disease organisms include those that…”
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Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts
Published in Cell (25-08-2016)“…Cellular compartments that cannot be biochemically isolated are challenging to characterize. Here we demonstrate the proteomic characterization of the synaptic…”
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The Q175 mouse model of Huntington's disease shows gene dosage- and age-related decline in circadian rhythms of activity and sleep
Published in PloS one (30-07-2013)“…Sleep and circadian disruptions are commonly reported by patients with neurodegenerative diseases, suggesting these may be an endophenotype of the disorders…”
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7
Built environment and physical activity among adolescents: the moderating effects of neighborhood safety and social support
Published in The international journal of behavioral nutrition and physical activity (18-12-2019)“…Increasing emphasis has been placed on improving physical activity levels through multilevel interventions. This study aims to examine moderating effects of…”
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8
Precision Spectroscopy of Polarized Molecules in an Ion Trap
Published in Science (American Association for the Advancement of Science) (06-12-2013)“…Polar molecules are desirable systems for quantum simulations and cold chemistry. Molecular ions are easily trapped, but a bias electric field applied to…”
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9
PINK1 cleavage at position A103 by the mitochondrial protease PARL
Published in Human molecular genetics (01-03-2011)“…Mutations in PTEN-induced kinase 1 (PINK1) cause early onset autosomal recessive Parkinson's disease (PD). PINK1 is a 63 kDa protein kinase, which exerts a…”
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10
Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease
Published in Nature cell biology (01-02-2014)“…Mutations in PINK1 cause early-onset Parkinson’s disease (PD). Studies in Drosophila melanogaster have highlighted mitochondrial dysfunction on loss of Pink1…”
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11
Loss of PRC2 subunits primes lineage choice during exit of pluripotency
Published in Nature communications (30-11-2021)“…Polycomb Repressive Complex 2 (PRC2) is crucial for the coordinated expression of genes during early embryonic development, catalyzing histone H3 lysine 27…”
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12
Role of T helper 17 cells and T regulatory cells in alopecia areata: comparison of lesion and serum cytokine between controls and patients
Published in Journal of the European Academy of Dermatology and Venereology (01-06-2018)“…Background Alopecia areata (AA) is an organ‐specific autoimmune disease with T‐cell‐mediated attack of hair follicle autoantigens. As T helper 17 (Th17) cells…”
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13
Development and Validation of a Tool to Screen for Cognitive Frailty Among Community-Dwelling Elders
Published in The Journal of nutrition, health & aging (01-11-2019)“…Objectives Reciprocal age-related impairments in physical and cognitive functioning have been termed ‘cognitive frailty’, which is associated with adverse…”
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Long-Term Mortality Risk in Older Adults with Sarcopenia: An 11-Year Prospective Cohort Study Comparing AWGS 2014 and AWGS 2019 Guidelines for Enhanced Clinical Utility and Accurate Risk Prediction
Published in The Journal of nutrition, health & aging (01-07-2023)“…Objectives To discern the diagnostic accuracy between the updated diagnostic consensus of the Asian Working Group for Sarcopenia (AWGS) in 2019 (AWGS 2019) and…”
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15
Acute myocardial infarction and myocarditis following COVID-19 vaccination
Published in QJM : An International Journal of Medicine (29-04-2023)“…Abstract Emerging reports raise concerns on the potential association between the COVID-19 vaccines and cardiac manifestations. We sought to evaluate cardiac…”
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16
Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
Published in Cell death & disease (25-06-2021)“…Alzheimer’s disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer’s disease associated with the accumulation of a…”
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Circadian dysfunction in a mouse model of Parkinson's disease
Published in Experimental neurology (01-11-2011)“…Many Parkinson's disease (PD) patients exhibit sleep disorders as part of their symptoms with evidence suggesting that REM sleep disorders may be intimately…”
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Malignant Transformation in Porokeratosis Ptychotropica: A Systematic Review
Published in Acta dermato-venereologica (10-10-2024)“…Porokeratosis ptychotropica (PP) is a rare and unusual variant of porokeratosis. There is a dearth of information on the natural history, epidemiology, and…”
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Transcriptional and Epigenetic Regulation of Opioid Receptor Genes: Present and Future
Published in Annual review of pharmacology and toxicology (01-01-2011)“…Three opioid receptors (ORs) are known: μ opioid receptors (MORs), δ opioid receptors (DORs), and κ opioid receptors (KORs). Each is encoded by a distinct…”
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Targeting Transmission Pathways for Emerging Zoonotic Disease Surveillance and Control
Published in Vector borne and zoonotic diseases (Larchmont, N.Y.) (01-07-2015)“…We used literature searches and a database of all reported emerging infectious diseases (EIDs) to analyze the most important transmission pathways (e.g.,…”
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