Search Results - "Loh, Boon Shing"
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Using Machine Learning to Predict the Antibacterial Activity of Ruthenium Complexes
Published in Angewandte Chemie International Edition (04-03-2024)“…Rising antimicrobial resistance (AMR) and lack of innovation in the antibiotic pipeline necessitate novel approaches to discovering new drugs. Metal complexes…”
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Maschinelles Lernen zur Vorhersage antibakterieller Aktivität von Ruthenium‐Komplexen
Published in Angewandte Chemie (04-03-2024)“…Die steigende antimikrobielle Resistenz (AMR) und der Mangel an Innovation in der Antibiotikaforschung erfordern neue Ansätze zur Entwicklung von Medikamenten…”
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“Illuminating” Echinocandins’ Mechanism of Action
Published in ACS central science (28-10-2020)“…Tracking caspofungin accumulation is key for a better understanding of drug resistance in pathogenic fungi…”
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Targeted Antibacterial Strategy Based on Reactive Oxygen Species Generated from Dioxygen Reduction Using an Organoruthenium Complex
Published in JACS Au (27-09-2021)“…Pathogenic microorganisms pose a serious threat to global public health due to their persistent adaptation and growing resistance to antibiotics. Alternative…”
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Targeting Pathogenic Formate-Dependent Bacteria with a Bioinspired Metallo–Nitroreductase Complex
Published in Journal of the American Chemical Society (22-03-2023)“…Nitroreductases (NTRs) constitute an important class of oxidoreductase enzymes that have evolved to metabolize nitro-containing compounds. Their unique…”
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