Search Results - "Logunov, D Y"

Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity by Latanova, A. A., Petkov, S., Kilpelainen, A., Jansons, J., Latyshev, O. E., Kuzmenko, Y. V., Hinkula, J., Abakumov, M. A., Valuev-Elliston, V. T., Gomelsky, M., Karpov, V. L., Chiodi, F., Wahren, B., Logunov, D. Y., Starodubova, E. S., Isaguliants, M. G.

“…DNA vaccines require a considerable enhancement of immunogenicity. Here, we optimized a prototype DNA vaccine against drug-resistant HIV-1 based on a weak…”
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Safety and immunogenicity of GamEvac-Combi, a heterologous VSV- and Ad5-vectored Ebola vaccine: An open phase I/II trial in healthy adults in Russia by Dolzhikova, I. V., Zubkova, O. V., Tukhvatulin, A. I., Dzharullaeva, A. S., Tukhvatulina, N. M., Shcheblyakov, D. V., Shmarov, M. M., Tokarskaya, E. A., Simakova, Y. V., Egorova, D. A., Scherbinin, D. N., Tutykhina, I. L., Lysenko, A. A., Kostarnoy, A. V., Gancheva, P. G., Ozharovskaya, T. A., Belugin, B. V., Kolobukhina, L. V., Pantyukhov, V. B., Syromyatnikova, S. I., Shatokhina, I. V., Sizikova, T. V., Rumyantseva, I. G., Andrus, A. F., Boyarskaya, N. V., Voytyuk, A. N., Babira, V. F., Volchikhina, S. V., Kutaev, D. A., Bel'skih, A. N., Zhdanov, K. V., Zakharenko, S. M., Borisevich, S. V., Logunov, D. Y., Naroditsky, B. S., Gintsburg, A. L.

“…Ebola hemorrhagic fever, also known as Ebola virus disease or EVD, is one of the most dangerous viral diseases in humans and animals. In this open-label,…”
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Mycoplasma infection suppresses p53, activates NF-κB and cooperates with oncogenic Ras in rodent fibroblast transformation by Logunov, D Y, Scheblyakov, D V, Zubkova, O V, Shmarov, M M, Rakovskaya, I V, Gurova, K V, Tararova, N D, Burdelya, L G, Naroditsky, B S, Ginzburg, A L, Gudkov, A V

“…Prokaryotes of the genus Mycoplasma are the smallest cellular organisms that persist as obligate extracellular parasites. Although mycoplasma infection is…”
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Assessment of the Parameters of Adaptive Cell-Mediated Immunity in Naïve Common Marmosets (Callithrix jacchus) by Gordeychuk, I V, Tukhvatulin, A I, Petkov, S P, Abakumov, M A, Gulyaev, S A, Tukhvatulina, N M, Gulyaeva, T V, Mikhaylov, M I, Logunov, D Y, Isaguliants, M G

“…Common marmosets are small New World primates that have been increasingly used in biomedical research. This report presents efficient protocols for assessment…”
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Restoration of p53 tumor-suppressor activity in human tumor cells in vitro and in their xenografts in vivo by recombinant avian adenovirus CELO-p53 by LOGUNOV, D. Y, ILYINSKAYA, G. V, CHERENOVA, L. V, VERHOVSKAYA, L. V, SHMAROV, M. M, CHUMAKOV, P. M, KOPNIN, B. P, NARODITSKY, B. S

“…Human adenovirus (Ad) vectors are extensively used as gene transfer vehicles. However, a serious obstacle for the use of these vectors in clinical applications…”
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Variability of nonpathogenic influenza virus H5N3 under immune pressure by Timofeeva, T A, Rudneva, I A, Sadykova, G K, Lomakina, N F, Lyashko, A V, Shilov, A A, Voronina, O L, Aksenova, E I, Ryzhova, N N, Kunda, M S, Asatryan, M N, Shcherbinin, D N, Timofeeva, E B, Kushch, A A, Prilipov, A G, Adams, S E, Logunov, D Y, Narodisky, B S, Gintsburg, A L

“…Mutations arising in influenza viruses that have undergone immune pressure may promote a successful spread of mutants in nature. In order to evaluate the…”
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Gene therapy of amyotrophic lateral sclerosis by Zavalishin, I. A, Bochkov, N. P, Suslina, Z. A, Zakharova, M. N, Tarantul, V. Z, Naroditskiy, B. S, Suponeva, N. A, Illarioshkin, S. N, Shmarov, M. M, Logunov, D. Y, Tutyhina, I. L, Verkhovskaya, L. V, Sedova, E. S, Vasiliev, A. V, Brylev, L. V, Ginzburg, A. L

“…Two-year experiments were performed to evaluate the neurotrophic effect of hypoxia-inducible factors (vascular endothelial growth factor and angiogenin)…”
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Preclinical Studies of Immunogenity, Protectivity, and Safety of the Combined Vector Vaccine for Prevention of the Middle East Respiratory Syndrome by Dolzhikova, I V, Grousova, D M, Zubkova, O V, Tukhvatulin, A I, Kovyrshina, A V, Lubenets, N L, Ozharovskaia, T A, Popova, O, Esmagambetov, I B, Shcheblyakov, D V, Evgrafova, I M, Nedorubov, A A, Gordeichuk, I V, Gulyaev, S A, Botikov, A G, Panina, L V, Mishin, D V, Loginova, S Y, Borisevich, S V, Deryabin, P G, Naroditsky, B S, Logunov, D Y, Gintsburg, A L

“…The Middle East Respiratory Syndrome (MERS) is an acute inflammatory disease of the respiratory system caused by the MERS-CoV coronavirus. The mortality rate…”
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1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues - Novel Inhibitors of Human Adenovirus Replication by Nikitenko, N A, Gureeva, E S, Ozerov, A A, Tukhvatulin, A I, Izhaeva, F M, Prassolov, V S, Deryabin, P G, Novikov, M S, Logunov, D Y

“…Adenovirus infections are characterized by widespread distribution. The lack of causal therapy, which is effective in treating this group of diseases, explains…”
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Virus-Vectored Ebola Vaccines by Dolzhikova, I V, Tokarskaya, E A, Dzharullaeva, A S, Tukhvatulin, A I, Shcheblyakov, D V, Voronina, O L, Syromyatnikova, S I, Borisevich, S V, Pantyukhov, V B, Babira, V F, Kolobukhina, L V, Naroditsky, B S, Logunov, D Y, Gintsburg, A L

“…The Ebola virus disease (EVD) is one of the most dangerous infections affecting humans and animals. The first EVD outbreaks occurred in 1976 in Sudan and…”
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Immunogenicity of Different Forms of Middle East Respiratory Syndrome S Glycoprotein by Ozharovskaia, T A, Zubkova, O V, Dolzhikova, I V, Gromova, A S, Grousova, D M, Tukhvatulin, A I, Popova, O, Shcheblyakov, D V, Scherbinin, D N, Dzharullaeva, A S, Erokhova, A S, Shmarov, M M, Loginova, S Y, Borisevich, S V, Naroditsky, B S, Logunov, D Y, Gintsburg, A L

“…The Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in 2012 during the first Middle East respiratory syndrome (MERS) outbreaks. MERS-CoV…”
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Toll-Like Receptors (TLRs): The Role in Tumor Progression by Shcheblyakov, D V, Logunov, D Y, Tukhvatulin, A I, Shmarov, M M, Naroditsky, B S, Gintsburg, A L

“…Toll-like receptors (TLRs) are major components of the innate immune system that recognize the conserved molecular structures of pathogens (pathogen-associated…”
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Recombinant avian adenovirus CELO expressing the human interleukin-2: characterization in vitro, in ovo and in vivo by Cherenova, L.V., Logunov, D.Y., Shashkova, E.V., Shmarov, M.M., Verkhovskaya, L.V., Neugodova, G.L., Kazansky, D.B., Doronin, K.K., Naroditsky, B.S.

“…In our study, a recombinant adenovirus based on the avian adenovirus CELO genome, has been constructed that contains the human interleukin-2 gene. We have…”
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Triggering of Toll-like Receptor-2 in Mouse Myelomonocytic Leukaemia Cells WEHI-3B Leads to the Suppression of Apoptosis and Promotes Tumor Progression in Vivo by Shcheblyakov, D V, Logunov, D Y, Rakovskaya, I V, Shmarov, M M, Naroditsky, B S, Ginzburg, A L

“…Toll-like receptors are the essential components of innate immunity. It is shown that TLRs play an essential role in the immune resistance of an organism to…”
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A In Vitro and In Vivo Study of the Ability of NOD1 Ligands to Activate the Transcriptional Factor NF-kB by Tukhvatulin, A I, Logunov, D Y, Gitlin, I I, Shmarov, M M, Kudan, P V, Adzhieva, Capital A Cyrillic А, Moroz, A F, Kostyukova, N N, Burdelya, L G, Naroditsky, B S, Gintsburg, A L, Gudkov, A V

“…Pattern-recognition receptors (PRR) play a crucial role in the induction of the defense reactions of the immune system against pathogenic bacterial and viral…”
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Induction of a Protective Heterosubtypic Immune Response Against the Influenza Virus by using Recombinant Adenoviral Vectors Expressing Hemagglutinin of the Influenza H5 Virus by Shmarov, M M, Sedova, E S, Verkhovskaya, L V, Rudneva, I A, Bogacheva, E A, Barykova, Yu A, Shcherbinin, D N, Lysenko, A A, Tutykhina, I L, Logunov, D Y, Smirnov, Yu A, Naroditsky, B S, Gintsburg, A L

“…Influenza viruses are characterized by a high degree of antigenic variability, which causes the annual emergence of flu epidemics and irregularly timed…”
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Influence of integrin-binding motif (RGD) on the attachment and internalization of avian adenovirus CELO in mammalian cells by Zubkova, O. V., Logunov, D. Y., Karpov, A. P., Shmarov, M. M., Belousova, R. V., Naroditsky, B. S.

“…Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a long-fiber HI loop was designed. Experiments in vitro revealed that the…”
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Construction of the vector based on the CELO avian adenovirus genome providing enhanced expression of gene of secreted alkaline phosphatase in nonpermissive system in vitro and on vivo by Tutykhina, I. L., Shmarov, M. M., Logunov, D. Y., Grabko, V. I., Sevastyanova, G. A., Naroditskii, B. S., Gintsburg, A. L.

“…Adenovirus CELO is a promising vector for gene delivery to eukaryotic cells including mammalian cells. It allows one to use recombinant CELO adenoviruses…”
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Vaccines to prevent Ebola virus disease: current challenges and perspectives by Kovyrshina, Anna V., Sizikova, Tatiana E., Lebedev, Vitaliy N., Borisevich, Sergey V., Dolzhikova, Inna V., Logunov, Denis Yu, Gintsburg, Alexander L.

“…Relevance. Ebola virus disease (EVD) is an acute infectious disease with an extremely high case fatality rate reaching up to 90%. EVD has become widely known…”
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The role of proinflammatory and anti-inflammatory cytokines in bacterial pneumonia. Review by Zinina, Elizaveta P., Tsarenko, S. V., Logunov, D. Y., Tukhvatulin, A. I., Babayants, A. V., Avramov, А. А.

“…Hospital-acquired pneumonia is a common cause of mortality in intensive care units. Therapy effectiveness depends on the antibiotic regimen chosen. Serum…”
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