Search Results - "Loganathan, Gopalakrishnan"

Differential cytotoxicity, ER/oxidative stress, dysregulated AMPKα signaling, and mitochondrial stress by ethanol and its metabolites in human pancreatic acinar cells by Srinivasan, Mukund P., Bhopale, Kamlesh K., Caracheo, Anna A., Kaphalia, Lata, Loganathan, Gopalakrishnan, Balamurugan, Appakalai N., Rastellini, Cristiana, Kaphalia, Bhupendra S.

“…Background Alcoholic chronic pancreatitis (ACP) is a serious inflammatory disorder of the exocrine pancreatic gland. A previous study from this laboratory…”
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Improved recovery of human islets from young donor pancreases utilizing increased protease dose to collagenase for digesting peri‐islet extracellular matrix by Loganathan, Gopalakrishnan, Subhashree, Venugopal, Narayanan, Siddharth, Tweed, Benjamin, Andrew Goedde, Michael, Gunaratnam, Bakeerathan, Tucker, William W., Goli, Praneeth, Mokshagundam, Sriprakash, McCarthy, Robert C., Williams, Stuart K., Hughes, Michael G., Balamurugan, Appakalai N.

“…Human islet isolation from young donor pancreases (YDP) utilizing the current purified standard dose of collagenase‐protease enzyme mixtures often results in…”
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Antiapoptotic Actions of Exendin-4 against Hypoxia and Cytokines Are Augmented by CREB by Velmurugan, Kalpana, Balamurugan, A. N, Loganathan, Gopalakrishnan, Ahmad, Aftab, Hering, Bernhard J, Pugazhenthi, Subbiah

“…Islets isolated from cadaveric donor pancreas are functionally viable and can be transplanted in diabetic patients to reduce insulin requirements. This…”
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A New Enzyme Mixture to Increase the Yield and Transplant Rate of Autologous and Allogeneic Human Islet Products by BALAMURUGAN, A. N, LOGANATHAN, Gopalakrishnan, PAPAS, Klearchos K, MCCARTHY, Robert, SUTHERLAND, David E. R, HERING, Bernhard J, BELLIN, Melena D, WILHELM, Joshua J, HARMON, James, ANAZAWA, Takayuki, SOLTANI, Sajjad M, RADOSEVICH, David M, YUASA, Takeshi, TIWARI, Mukesh

“…The optimal enzyme blend that maximizes human islet yield for transplantation remains to be determined. In this study, we evaluated eight different enzyme…”
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Beneficial effect of recombinant rC1rC2 collagenases on human islet function: Efficacy of low‐dose enzymes on pancreas digestion and yield by Loganathan, Gopalakrishnan, Subhashree, Venugopal, Breite, Andrew G., Tucker, William W., Narayanan, Siddharth, Dhanasekaran, Maheswaran, Mokshagundam, SriPrakash, Green, Michael L., Hughes, Michael G., Williams, Stuart K., Dwulet, Francis E., McCarthy, Robert C., Balamurugan, Appakalai N.

“…A high number of human islets can be isolated by using modern purified tissue dissociation enzymes; however, this requires the use of >20 Wunsch units (WU)/g…”
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A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation by Wang, Ling-Jia, Kin, Tatsuya, O'Gorman, Doug, Shapiro, A M James, Naziruddin, Bashoo, Takita, Morihito, Levy, Marlon F, Posselt, Andrew M, Szot, Gregory L, Savari, Omid, Barbaro, Barbara, McGarrigle, James, Yeh, Chun Chieh, Oberholzer, Jose, Lei, Ji, Chen, Tao, Lian, Moh, Markmann, James F, Alvarez, Alejandro, Linetsky, Elina, Ricordi, Camillo, Balamurugan, A N, Loganathan, Gopalakrishnan, Wilhelm, Joshua J, Hering, Bernhard J, Bottino, Rita, Trucco, Massimo, Liu, Chengyang, Min, Zaw, Li, Yanjing, Naji, Ali, Fernandez, Luis A, Ziemelis, Martynas, Danobeitia, Juan S, Millis, J Michael, Witkowski, Piotr

“…Selection of an optimal donor pancreas is the first key task for successful islet isolation. We conducted a retrospective multicenter study in 11 centers in…”
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Ductal Cell Reprogramming to Insulin-Producing Beta-Like Cells as a Potential Beta Cell Replacement Source for Chronic Pancreatitis by Jawahar, Aravinth P, Narayanan, Siddharth, Loganathan, Gopalakrishnan, Pradeep, Jithu, Vitale, Gary C, Jones, Christopher M, Hughes, Michael G, Williams, Stuart K, Balamurugan, Appakalai N

“…Islet cell auto-transplantation is a novel strategy for maintaining blood glucose levels and improving the quality of life in patients with chronic…”
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Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells by Srinivasan, Padmanabhan, Thrower, Edwin C, Loganathan, Gopalakrishnan, Balamurugan, A N, Subramanian, Veedamali S, Gorelick, Fred S, Said, Hamid M

“…Thiamin (vitamin B1), a member of the water-soluble family of vitamins, is essential for normal cellular functions; its deficiency results in oxidative stress…”
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Successful human islet isolation and transplantation indicating the importance of class 1 collagenase and collagen degradation activity assay by Balamurugan, A N, Breite, Andrew G, Anazawa, Takayuki, Loganathan, Gopalakrishnan, Wilhelm, Joshua J, Papas, Klearchos K, Dwulet, Francis E, McCarthy, Robert C, Hering, Bernhard J

“…Purified tissue dissociation enzymes (TDEs) are critical to successful human islet isolation required for clinical transplantation, but little is known about…”
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Prediction of Pancreatic Tissue Densities by an Analytical Test Gradient System Before Purification Maximizes Human Islet Recovery for Islet Autotransplantation/Allotransplantation by ANAZAWA, Takayuki, MATSUMOTO, Shuichiro, YONEKAWA, Yukihide, LOGANATHAN, Gopalakrishnan, WILHELM, Joshua J, SOLTANI, Sajjad M, PAPAS, Klearchos K, SUTHERLAND, David E. R, HERING, Bernhard J, BALAMURUGAN, A. N

“…Using standard density gradient (SDG) ranges for human islet purification frequently results in islet loss and transplantation of lower islet mass. Measuring…”
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Identifying Effective Enzyme Activity Targets for Recombinant Class I and Class II Collagenase for Successful Human Islet Isolation by Balamurugan, Appakalai N., Green, Michael L., Breite, Andrew G., Loganathan, Gopalakrishnan, Wilhelm, Joshua J., Tweed, Benjamin, Vargova, Lenka, Lockridge, Amber, Kuriti, Manikya, Hughes, Michael G., Williams, Stuart K., Hering, Bernhard J., Dwulet, Francis E., McCarthy, Robert C.

“…Isolation following a good manufacturing practice-compliant, human islet product requires development of a robust islet isolation procedure where effective…”
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Clinical islet cell transplantation – recent advances by Saravanan, Prathab Balaji, Loganathan, Gopalakrishnan, Naziruddin, Bashoo, Balamurugan, Appakalai N.

“…Type-1 diabetes mellitus (T1DM) caused by autoimmune destruction of insulin-producing beta-cells essentially requires treatment with exogenous insulin therapy…”
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Human pancreatic tissue dissociation enzymes for islet isolation: Advances and clinical perspectives by Loganathan, Gopalakrishnan, Balamurugan, Appakalai N., Venugopal, Subhashree

“…Successful clinical human allo or auto-islet transplantation requires the recovery of a sufficient number of functional islets from either brain-dead or…”
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Correction to: trisected pancreas model for testing tissue dissociation enzyme combinations: a novel methodology for improving human islet yield for clinical islet transplantation by Loganathan, Gopalakrishnan, Venugopal, Subhashree, Balamurugan, Appakalai N.

“…A Correction to this paper has been published: https://doi.org/10.1007/s40200-021-00747-w…”
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Trisected pancreas model for testing tissue dissociation enzyme combinations: a novel methodology for improving human islet yield for clinical islet transplantation by Loganathan, Gopalakrishnan, Venugopal, Subhashree, Balamurugan, Appakalai N.

“…Purpose Human islet isolation requires a defined collagenase-protease enzyme combination for obtaining a successful islet yield. While different islet…”
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Activation of AMP-activated protein kinase attenuates ethanol-induced ER/oxidative stress and lipid phenotype in human pancreatic acinar cells by Srinivasan, Mukund P., Bhopale, Kamlesh K., Caracheo, Anna A., Amer, Samir M., Khan, Shamis, Kaphalia, Lata, Loganathan, Gopalakrishnan, Balamurugan, Appakalai N., Kaphalia, Bhupendra S.

“…[Display omitted] Primary toxicity targets of alcohol and its metabolites in the pancreas are cellular energetics and endoplasmic reticulum (ER). Therefore,…”
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Endothelial cell regulation through epigenetic mechanisms: Depicting parallels and its clinical application within an intra-islet microenvironment by Narayanan, Siddharth, Loganathan, Gopalakrishnan, Mokshagundam, SriPrakash, Hughes, Michael G., Williams, Stuart K., Balamurugan, Appakalai N.

“…The intra-islet endothelial cells (ECs), the building blocks of islet microvasculature, govern a number of cellular and pathophysiological processes associated…”
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Islet Oxygen Consumption Rate (OCR) Dose Predicts Insulin Independence in Clinical Islet Autotransplantation by Papas, Klearchos K, Bellin, Melena D, Sutherland, David E R, Suszynski, Thomas M, Kitzmann, Jennifer P, Avgoustiniatos, Efstathios S, Gruessner, Angelika C, Mueller, Kathryn R, Beilman, Gregory J, Balamurugan, Appakalai N, Loganathan, Gopalakrishnan, Colton, Clark K, Koulmanda, Maria, Weir, Gordon C, Wilhelm, Josh J, Qian, Dajun, Niland, Joyce C, Hering, Bernhard J

“…Reliable in vitro islet quality assessment assays that can be performed routinely, prospectively, and are able to predict clinical transplant outcomes are…”
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Pig islet xenotransplantation by Dhanasekaran, Maheswaran, George, Johnathan J., Loganathan, Gopalakrishnan, Narayanan, Siddharth, Hughes, Michael G., Williams, Stuart K., Balamurugan, Appakalai N.

“…The current article reviews the rationale, sources and preparation of pig islets for xenotransplantation, and presents current progress in solving the problems…”
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Factors Affecting Transplant Outcomes in Diabetic Nude Mice Receiving Human, Porcine, and Nonhuman Primate Islets: Analysis of 335 Transplantations by Loganathan, Gopalakrishnan, Graham, Melanie L, Radosevich, David M, Soltani, Sajjad M, Tiwari, Mukesh, Anazawa, Takayuki, Papas, Klearchos K, Sutherland, David E.R, Hering, Bernhard J, Balamurugan, A.N

“…BACKGROUNDIn the absence of a reliable islet potency assay, nude mice (NM) transplantation is the criterion standard to assess islet quality for clinical…”
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