Search Results - "Loganathan, Chitra"

Microsecond Molecular Dynamics Simulation to Gain Insight Into the Binding of MRTX1133 and Trametinib With KRASG12D Mutant Protein for Drug Repurposing by Ancy, Iruthayaraj, Penislusshiyan, Sakayanathan, Ameen, Fuad, Chitra, Loganathan

“…ABSTRACT The Kirsten Rat Sarcoma (KRAS) G12D mutant protein is a primary driver of pancreatic ductal adenocarcinoma, necessitating the identification of…”
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Novel antioxidant astaxanthin-s-allyl cysteine biconjugate diminished oxidative stress and mitochondrial dysfunction to triumph diabetes in rat model by Penislusshiyan, Sakayanathan, Chitra, Loganathan, Ancy, Iruthayaraj, Kumaradhas, Poomani, Palvannan, Thayumanavan

“…The present study determines the effect of administration of novel antioxidant astaxanthin-s-allyl cysteine biconjugate (AST-SAC) against…”
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Dual antidiabetic and antihypertensive activity of fucoxanthin isolated from Sargassum wightii Greville in in vivo rat model by Raji, Vijayan, Loganathan, Chitra, Ramesh, Thiyagarajan, Thayumanavan, Palvannan

“…In a previous study from our laboratory, fucoxanthin purified from brown algae, Sargassum wightii Greville has found to exhibit antioxidant activity and…”
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Exploring bioactive fraction of Sargassum wightii: In vitro elucidation of angiotensin-I-converting enzyme inhibition and antioxidant potential by Vijayan, Raji, Chitra, Loganathan, Penislusshiyan, Sakayanathan, Palvannan, Thayumanavan

“…Bioactive fraction of brown algae Sargassum wightii (SWE) was obtained using silica column chromatography and preparative Thin Layer Chromatography (TLC)…”
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In vitro and in silico analysis of novel astaxanthin-s-allyl cysteine as an inhibitor of butyrylcholinesterase and various globular forms of acetylcholinesterases by Sakayanathan, Penislusshiyan, Loganathan, Chitra, Kandasamy, Saravanan, Ramanna, Rajesh V., Poomani, Kumaradhas, Thayumanavan, Palvannan

“…In Alzheimer's disease (AD) and diabetes-associated cognitive decline, the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity is increased…”
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Green synthesized selenium nanoparticles using Spermacoce hispida as carrier of s-allyl glutathione: to accomplish hepatoprotective and nephroprotective activity against acetaminophen toxicity by Krishnan, Vennila, Loganathan, Chitra, Thayumanavan, Palvannan

“…s-allyl glutathione (SAG) an analogue of glutathione is explored for its antioxidative and liver protection property in recent years. Selenium nanoparticles…”
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S-allyl cysteine as potent anti-gout drug: Insight into the xanthine oxidase inhibition and anti-inflammatory activity by Johnson, Preethi, Loganathan, Chitra, Iruthayaraj, Ancy, Poomani, Kumaradhas, Thayumanavan, Palvannan

“…S-allyl cysteine (SAC) is known for its various beneficial effects such as neuroprotection and immunomodulation. The beneficial effect of SAC against gout has…”
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S-allyl-glutathione, a synthetic analogue of glutathione protected liver against carbon tetrachloride toxicity: Focus towards anti-oxidative efficiency by Thayumanavan, Palvannan, Loganathan, Chitra, Iruthayaraj, Ancy, Poomani, Kumaradhas, Nallaiyan, Selvan

“…[Display omitted] •S-allyl-glutathione (SAG) evaluated against CCl4-induced liver injury.•SAG preserved the liver function against CCl4 toxicity.•SAG increased…”
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Asiatic acid prevents the quinolinic acid-induced oxidative stress and cognitive impairment by Loganathan, Chitra, Thayumanavan, Palvannan

“…Increased accumulation of endogenous neurotoxin quinolinic acid has been found in various neurodegenerative diseases. Oxidative stress caused by quinolinic…”
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Astaxanthin‐S‐Allyl Cysteine Ester Protects Pancreatic β‐Cell From Glucolipotoxicity by Suppressing Oxidative Stress, Endoplasmic Reticulum Stress and mTOR Pathway Dysregulation by Sakayanathan, Penislusshiyan, Loganathan, Chitra, Thayumanavan, Palvannan

“…ABSTRACT Glucolipotoxicity (GLT) has emerged as established mechanism in the progression of diabetes. Identifying compounds that mitigate GLT‐induced…”
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Astaxanthin-s-allyl cysteine diester against high glucose-induced neuronal toxicity in vitro and diabetes-associated cognitive decline in vivo: Effect on p53, oxidative stress and mitochondrial function by Loganathan, Chitra, Sakayanathan, Penislusshiyan, Thayumanavan, Palvannan

“…•AST-SAC protected the neuronal cells against high glucose (HG) toxicity in vitro.•AST-SAC decreased oxidative stress and preserved mitochondria against…”
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Protection of pancreatic beta cells against high glucose-induced toxicity by astaxanthin-s-allyl cysteine diester: alteration of oxidative stress and apoptotic-related protein expression by Sakayanathan, Penislusshiyan, Loganathan, Chitra, Thayumanavan, Palvannan

“…Purpose: High glucose (HG)-induced oxidative stress is associated with apoptosis in pancreatic β-cells. The protective effect of astaxanthin-s-allyl cysteine…”
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Adaptability to hypobaric hypoxia is facilitated through mitochondrial bioenergetics: an in vivo study by Chitra, Loganathan, Boopathy, Rathanam

“…Background and Purpose High‐altitude pulmonary oedema (HAPE) experienced under high‐altitude conditions is attributed to mitochondrial redox distress. Hence,…”
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Microsecond Molecular Dynamics Simulation to Gain Insight Into the Binding of MRTX1133 and Trametinib With KRAS G12D Mutant Protein for Drug Repurposing by Ancy, Iruthayaraj, Penislusshiyan, Sakayanathan, Ameen, Fuad, Chitra, Loganathan

“…The Kirsten Rat Sarcoma (KRAS) G12D mutant protein is a primary driver of pancreatic ductal adenocarcinoma, necessitating the identification of targeted drug…”
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Astaxanthin‐s‐allyl cysteine diester attenuated high glucose‐induced oxidative stress toxicity in neuronal cells through protection of mitochondria in vitro by Loganathan, Chitra, Sakayanathan, Penislusshiyan, Thayumanavan, Palvannan

“…Background Cognitive dysfunction associate with diabetes is related to high glucose‐induced oxidative stress toxicity in neuronal cells. Hence, identifying…”
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Green synthesized selenium nanoparticle as carrier and potent delivering agent of s-allyl glutathione: Anticancer effect against hepatocarcinoma cell line (HepG2) through induction of cell cycle arrest and apoptosis by Krishnan, Vennila, Loganathan, Chitra, Thayumanavan, Palvannan

“…S-allyl glutathione (SAG) is an analog of glutathione (GSH) synthesized by alkalating the thiol group of GSH with the allyl group. Previously, SAG has shown…”
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Synthesis and Characterization of Plumbagin S-Allyl Cysteine Ester: Determination of Anticancer Activity In Silico and In Vitro by Vijayan, Sudha, Loganathan, Chitra, Sakayanathan, Penislusshiyan, Thayumanavan, Palvannan

“…In recent years, derivatives of natural compounds are synthesized to increase the bioavailability, pharmacology, and pharmacokinetics properties. The…”
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Altered mitochondrial biogenesis and its fusion gene expression is involved in the high-altitude adaptation of rat lung by Chitra, Loganathan, Boopathy, Rathanam

“…Highlights • IHH-PC regimen in rat stabilized the mitochondrial function of the lung tissue. • IHH-PC increased the mitochondrial number, mtDNA content and…”
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Isolation of bioactive components from Corallocarpus epigaeus tuber and inhibitory potential against various molecular forms of acetylcholinesterase by Loganathan, Chitra, Sakayanathan, Penislusshiyan, Thayumanavan, Palvannan

“…Background In human, acetylcholinesterase (AChE) is involved in cholinergic neurotransmission. AChE exhibits as different globular form such as G4 (tetramer),…”
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Isolation of bioactive components from Corallocarpus epigaeus tuber and inhibitory potential against various molecular forms of acetylcholinesterase: Nonhuman/Lead optimization studies by Loganathan, Chitra, Sakayanathan, Penislusshiyan, Thayumanavan, Palvannan

“…Abstract Background In human, acetylcholinesterase (AChE) is involved in cholinergic neurotransmission. AChE exhibits as different globular form such as G4…”
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