Search Results - "Logan, Jean"

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI by Iliff, Jeffrey J, Lee, Hedok, Yu, Mei, Feng, Tian, Logan, Jean, Nedergaard, Maiken, Benveniste, Helene

“…The glymphatic system is a recently defined brain-wide paravascular pathway for cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange that…”
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Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity by Volkow, Nora D, Wang, Gene-Jack, Telang, Frank, Fowler, Joanna S, Alexoff, David, Logan, Jean, Jayne, Millard, Wong, Christopher, Tomasi, Dardo

“…Moves to legalize marijuana highlight the urgency to investigate effects of chronic marijuana in the human brain. Here, we challenged 48 participants (24…”
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Graphical analysis of PET data applied to reversible and irreversible tracers by Logan, Jean

“…The differential equations of compartmental analysis form the basis of the models describing the uptake of tracers used in imaging studies. Graphical analyses…”
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Profound Decreases in Dopamine Release in Striatum in Detoxified Alcoholics: Possible Orbitofrontal Involvement by Volkow, Nora D, Wang, Gene-Jack, Telang, Frank, Fowler, Joanna S, Logan, Jean, Jayne, Millard, Ma, Yeming, Pradhan, Kith, Wong, Christopher

“…The value of rewards (natural rewards and drugs) is associated with dopamine increases in the nucleus accumbens and varies as a function of context. The…”
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Enhanced Striatal Dopamine Release During Food Stimulation in Binge Eating Disorder by Wang, Gene‐Jack, Geliebter, Allan, Volkow, Nora D., Telang, Frank W., Logan, Jean, Jayne, Millard C., Galanti, Kochavi, Selig, Peter A., Han, Hao, Zhu, Wei, Wong, Christopher T., Fowler, Joanna S.

“…Subjects with binge eating disorder (BED) regularly consume large amounts of food in short time periods. The neurobiology of BED is poorly understood. Brain…”
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Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men by Shumay, Elena, Logan, Jean, Volkow, Nora D., Fowler, Joanna S.

“…Human brain function is mediated by biochemical processes, many of which can be visualized and quantified by positron emission tomography (PET). PET brain…”
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Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands by Innis, Robert B, Cunningham, Vincent J, Delforge, Jacques, Fujita, Masahiro, Gjedde, Albert, Gunn, Roger N, Holden, James, Houle, Sylvain, Huang, Sung-Cheng, Ichise, Masanori, Iida, Hidehiro, Ito, Hiroshi, Kimura, Yuichi, Koeppe, Robert A, Knudsen, Gitte M, Knuuti, Juhani, Lammertsma, Adriaan A, Laruelle, Marc, Logan, Jean, Maguire, Ralph Paul, Mintun, Mark A, Morris, Evan D, Parsey, Ramin, Price, Julie C, Slifstein, Mark, Sossi, Vesna, Suhara, Tetsuya, Votaw, John R, Wong, Dean F, Carson, Richard E

“…An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding…”
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Inverse Association Between BMI and Prefrontal Metabolic Activity in Healthy Adults by Volkow, Nora D., Wang, Gene‐Jack, Telang, Frank, Fowler, Joanna S., Goldstein, Rita Z., Alia‐Klein, Nelly, Logan, Jean, Wong, Christopher, Thanos, Panayotis K., Ma, Yemine, Pradhan, Kith

“…Obesity has been associated with a higher risk for impaired cognitive function, which most likely reflects associated medical complications (i.e.,…”
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Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers by Ray, Riju, Ruparel, Kosha, Newberg, Andrew, Wileyto, E. Paul, Loughead, James W, Divgi, Chaitanya, Blendy, Julie A, Logan, Jean, Zubieta, Jon-Kar, Lerman, Caryn

“…Evidence points to the endogenous opioid system, and the mu-opioid receptor (MOR) in particular, in mediating the rewarding effects of drugs of abuse,…”
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Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder by Wang, Gene-Jack, Volkow, Nora D, Wigal, Timothy, Kollins, Scott H, Newcorn, Jeffrey H, Telang, Frank, Logan, Jean, Jayne, Millard, Wong, Christopher T, Han, Hao, Fowler, Joanna S, Zhu, Wei, Swanson, James M

“…Brain dopamine dysfunction in attention deficit/hyperactivity disorder (ADHD) could explain why stimulant medications, which increase dopamine signaling, are…”
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BMI modulates calorie-dependent dopamine changes in accumbens from glucose intake by Wang, Gene-Jack, Tomasi, Dardo, Convit, Antonio, Logan, Jean, Wong, Christopher T, Shumay, Elena, Fowler, Joanna S, Volkow, Nora D

“…Dopamine mediates the rewarding effects of food that can lead to overeating and obesity, which then trigger metabolic neuroadaptations that further perpetuate…”
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Brain Monoamine Oxidase A Activity Predicts Trait Aggression by Alia-Klein, Nelly, Goldstein, Rita Z, Kriplani, Aarti, Logan, Jean, Tomasi, Dardo, Williams, Benjamin, Telang, Frank, Shumay, Elena, Biegon, Anat, Craig, Ian W, Henn, Fritz, Wang, Gene-Jack, Volkow, Nora D, Fowler, Joanna S

“…The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine,…”
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A review of graphical methods for tracer studies and strategies to reduce bias by Logan, Jean

“…Graphical techniques provide simple methods for the analysis of data from tracer studies. They provide considerable ease of computation compared to the…”
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Human Cognitive Ability Is Modulated by Aromatase Availability in the Brain in a Sex-Specific Manner by Alia-Klein, Nelly, Preston-Campbell, Rebecca N., Kim, Sung Won, Pareto, Deborah, Logan, Jean, Wang, Gene-Jack, Moeller, Scott J., Fowler, Joanna S., Biegon, Anat

“…The enzyme aromatase catalyzes the final step in estrogen biosynthesis, converting testosterone to estradiol, and is expressed in the brain of all mammals…”
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Monoamine oxidase: radiotracer chemistry and human studies by Fowler, Joanna S., Logan, Jean, Shumay, Elena, Alia-Klein, Nelly, Wang, Gene-Jack, Volkow, Nora D.

“…Monoamine oxidase (MAO) oxidizes amines from both endogenous and exogenous sources thereby regulating the concentration of neurotransmitter amines such as…”
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Kinetic Analysis and Quantification of [11C]Martinostat for in Vivo HDAC Imaging of the Brain by Wey, Hsiao-Ying, Wang, Changning, Schroeder, Frederick A, Logan, Jean, Price, Julie C, Hooker, Jacob M

“…Epigenetic mechanisms mediated by histone deacetylases (HDACs) have been implicated in a wide-range of CNS disorders and may offer new therapeutic…”
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Methylphenidate decreased the amount of glucose needed by the brain to perform a cognitive task by Volkow, Nora D, Fowler, Joanna S, Wang, Gene-Jack, Telang, Frank, Logan, Jean, Wong, Christopher, Ma, Jim, Pradhan, Kith, Benveniste, Helene, Swanson, James M

“…The use of stimulants (methylphenidate and amphetamine) as cognitive enhancers by the general public is increasing and is controversial. It is still unclear…”
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Therapeutic Doses of Oral Methylphenidate Significantly Increase Extracellular Dopamine in the Human Brain by Volkow, Nora D, Wang, Gene-Jack, Fowler, Joanna S, Logan, Jean, Gerasimov, Madina, Maynard, Laurence, Ding, Yu-Shin, Gatley, Samuel J, Gifford, Andrew, Franceschi, Dinko

“…Methylphenidate (Ritalin) is the most commonly prescribed psychoactive drug in children for the treatment of attention deficit hyperactivity disorder (ADHD),…”
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Partial Recovery of Brain Metabolism in Methamphetamine Abusers After Protracted Abstinence by Wang, Gene-Jack, Volkow, Nora D., Chang, Linda, Miller, Eric, Sedler, Mark, Hitzemann, Robert, Zhu, Wei, Logan, Jean, Ma, Yeming, Fowler, Joanna S.

“…OBJECTIVE: Methamphetamine is a highly addictive drug of abuse that is neurotoxic to dopamine terminals. The authors recently reported that decreases in…”
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Time-varying SUVr reflects the dynamics of dopamine increases during methylphenidate challenges in humans by Tomasi, Dardo, Manza, Peter, Logan, Jean, Shokri-Kojori, Ehsan, Yonga, Michele-Vera, Kroll, Danielle, Feldman, Dana, McPherson, Katherine, Biesecker, Catherine, Dennis, Evan, Johnson, Allison, Yuan, Kai, Wang, Wen-Tung, Butman, John A., Wang, Gene-Jack, Volkow, Nora D.

“…Dopamine facilitates cognition and is implicated in reward processing. Methylphenidate, a dopamine transporter blocker widely used to treat…”
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