Search Results - "Loftus, Roisin"

Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells by Keating, Sinéad E, Zaiatz-Bittencourt, Vanessa, Loftus, Roisín M, Keane, Ciara, Brennan, Kiva, Finlay, David K, Gardiner, Clair M

“…Human NK cells can be classified into phenotypically and functionally distinct subsets based on levels of CD56 receptor. CD56(dim) cells are generally…”
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Metabolic reprogramming of natural killer cells in obesity limits antitumor responses by Michelet, Xavier, Dyck, Lydia, Hogan, Andrew, Loftus, Roisin M., Duquette, Danielle, Wei, Kevin, Beyaz, Semir, Tavakkoli, Ali, Foley, Cathriona, Donnelly, Raymond, O’Farrelly, Cliona, Raverdeau, Mathilde, Vernon, Ashley, Pettee, William, O’Shea, Donal, Nikolajczyk, Barbara S., Mills, Kingston H. G., Brenner, Michael B., Finlay, David, Lynch, Lydia

“…Up to 49% of certain types of cancer are attributed to obesity, and potential mechanisms include overproduction of hormones, adipokines, and insulin. Cytotoxic…”
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Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function by Dyck, Lydia, Prendeville, Hannah, Raverdeau, Mathilde, Wilk, Mieszko M, Loftus, Roisin M, Douglas, Aaron, McCormack, Janet, Moran, Bruce, Wilkinson, Michael, Mills, Evanna L, Doughty, Michael, Fabre, Aurelie, Heneghan, Helen, LeRoux, Carel, Hogan, Andrew, Chouchani, Edward T, O'Shea, Donal, Brennan, Donal, Lynch, Lydia

“…Obesity is one of the leading preventable causes of cancer; however, little is known about the effects of obesity on anti-tumor immunity. Here, we investigated…”
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Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments by Lopes, Noel, McIntyre, Claire, Martin, Stefania, Raverdeau, Mathilde, Sumaria, Nital, Kohlgruber, Ayano C., Fiala, Gina, Agudelo, Leandro Z., Dyck, Lydia, Kane, Harry, Douglas, Aaron, Cunningham, Stephen, Prendeville, Hannah, Loftus, Roisin, Carmody, Colleen, Pierre, Philippe, Kellis, Manolis, Brenner, Michael, Argüello, Rafael J., Silva-Santos, Bruno, Pennington, Daniel J., Lynch, Lydia

“…© The Author(s), under exclusive licence to Springer Nature America, Inc. 2021 Metabolic programming controls immune cell lineages and functions, but little is…”
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Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses by O'Brien, Aisling, Loftus, Roisin M, Pisarska, Marta M, Tobin, Laura M, Bergin, Ronan, Wood, Nicole A W, Foley, Cathriona, Mat, Arimin, Tinley, Frances C, Bannan, Ciaran, Sommerville, Gary, Veerapen, Natacha, Besra, Gurdyal S, Sinclair, Linda V, Moynagh, Paul N, Lynch, Lydia, Finlay, David K, O'Shea, Donal, Hogan, Andrew E

“…Obesity underpins the development of numerous chronic diseases, such as type II diabetes mellitus. It is well established that obesity negatively alters immune…”
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Correction: Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function by Dyck, Lydia, Prendeville, Hannah, Raverdeau, Mathilde, Wilk, Mieszko M, Loftus, Roisin M, Douglas, Aaron, McCormack, Janet, Moran, Bruce, Wilkinson, Michael, Mills, Evanna L, Doughty, Michael, Fabre, Aurelie, Heneghan, Helen, LeRoux, Carel, Hogan, Andrew, Chouchani, Edward T, O'Shea, Donal, Brennan, Donal, Lynch, Lydia

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Immunometabolism: Cellular Metabolism Turns Immune Regulator by Loftus, Róisín M., Finlay, David K.

“…Immune cells are highly dynamic in terms of their growth, proliferation, and effector functions as they respond to immunological challenges. Different immune…”
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mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function by Donnelly, Raymond P, Loftus, Róisín M, Keating, Sinéad E, Liou, Kevin T, Biron, Christine A, Gardiner, Clair M, Finlay, David K

“…The mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cellular metabolism and also has fundamental roles in controlling immune responses…”
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Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice by Loftus, Róisín M., Assmann, Nadine, Kedia-Mehta, Nidhi, O’Brien, Katie L., Garcia, Arianne, Gillespie, Conor, Hukelmann, Jens L., Oefner, Peter J., Lamond, Angus I., Gardiner, Clair M., Dettmer, Katja, Cantrell, Doreen A., Sinclair, Linda V., Finlay, David K.

“…Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation…”
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Srebp-controlled glucose metabolism is essential for NK cell functional responses by Assmann, Nadine, O'Brien, Katie L, Donnelly, Raymond P, Dyck, Lydia, Zaiatz-Bittencourt, Vanessa, Loftus, Róisín M, Heinrich, Paul, Oefner, Peter J, Lynch, Lydia, Gardiner, Clair M, Dettmer, Katja, Finlay, David K

“…NK cells are cytotoxic cells that combat tumors and viral infection. Finlay and colleagues show that the effector function of cytokine-activated NK cells…”
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TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway by Viel, Sébastien, Marçais, Antoine, Guimaraes, Fernando Souza-Fonseca, Loftus, Roisin, Rabilloud, Jessica, Grau, Morgan, Degouve, Sophie, Djebali, Sophia, Sanlaville, Amélien, Charrier, Emily, Bienvenu, Jacques, Marie, Julien C, Caux, Christophe, Marvel, Jacqueline, Town, Liam, Huntington, Nicholas D, Bartholin, Laurent, Finlay, David, Smyth, Mark J, Walzer, Thierry

“…Transforming growth factor-β (TGF-β) is a major immunosuppressive cytokine that maintains immune homeostasis and prevents autoimmunity through its…”
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mTORC1-dependent metabolic reprogramming is a prerequisite for Natural Killer cell effector function by Donnelly, Raymond P., Loftus, Róisín M., Keating, Sinéad E., Liou, Kevin T., Biron, Christine A., Gardiner, Clair M., Finlay, David K.

“…The mammalian target of rapamcyin complex 1 (mTORC1) is a key regulator of cellular metabolism and also has fundamental roles in controlling immune responses…”
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