Search Results - "Lofthouse, S."

Continuous antigen delivery from controlled release implants induces significant and anamnestic immune responses by Kemp, J.M, Kajihara, M, Nagahara, S, Sano, A, Brandon, M, Lofthouse, S

“…Two continuous delivery injectable silicone implants were tested to determine if they were capable of delivering vaccines in a single shot. The Type A implant…”
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Injectable silicone implants as vaccine delivery vehicles by Lofthouse, S.A, Kajihara, M, Nagahara, S, Nash, A, Barcham, G.J, Sedgmen, B, Brandon, M.R, Sano, A

“…Injectable silicone implants were assessed as vaccine delivery vehicles in sheep, using either the model antigen avidin or Clostridium tetani and Clostridium…”
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Peptide mimics of a tumor antigen induce functional cytotoxic T cells by Apostolopoulos, Vasso, Lofthouse, Shari A, Popovski, Violeta, Chelvanayagam, Gareth, Sandrin, Mauro S, McKenzie, lan F.C

“…The ability to mimic peptide/peptide and/or peptide/carbohydrate structures may be important in generating cross-reactive antibodies for autoimmune and other…”
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A GH receptor antisense oligonucleotide inhibits hepatic GH receptor expression, IGF-I production and body weight gain in normal mice by Tachas, G, Lofthouse, S, Wraight, C J, Baker, B F, Sioufi, N B, Jarres, R A, Berdeja, A, Rao, A M, Kerr, L M, d’Aniello, E M, Waters, M J

“…Diabetic retinopathy and acromegaly are diseases associated with excess action of GH and its effector IGF-I, and there is a need for improved therapies. We…”
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Humoral and cellular responses induced by intradermally administered cytokine and conventional adjuvants by Lofthouse, S.A., Andrews, A.E., Nash, A.D., Bowles, V.M.

“…Serum antibody responses to the model protein antigen avidin were monitored in sheep following intradermal injection of avidin formulated with a range of…”
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Induction of T1 (cytotoxic lymphocyte) and/or T2 (antibody) responses to a mucin-1 tumour antigen by LOFTHOUSE, S. A, APOSTOLOPOULOS, V, PIETERSZ, G. A, LI, W, MCKENZIE, I. F. C

“…Effective vaccination-based control of intracellular pathogens or parasites and various tumours is dependent upon induction of cytotoxic lymphocytes and other…”
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Pathological and immunological changes after challenge infection with Pasteurella multocida in naive and immunized calves by Mathy, N.L., Mathy, J.-P.D., Lee, R.P., Walker, J., Lofthouse, S., Meeusen, E.N.T.

“…Challenge infections of calves with Pasteurella multocida were established to characterize the local inflammatory response and determine the effect of previous…”
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Immunological aspects of controlled antigen delivery by Lofthouse, Shari

“…Recent advances in controlled delivery systems for protein pharmaceuticals such as microspheres, liposomes, pumps and implants, have provided a new avenue for…”
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Cytokines as adjuvants for ruminant vaccines by Lofthouse, S.A., Andrews, A.E., Elhay, M.J., Bowles, V.M., Meeusen, E.N.T., Nash, A.D.

“…Successful vaccination against any potential pathogen is critically dependant on inducing an appropriate immune response. The pivotal role of cytokines in the…”
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Production and in vivo use of recombinant ovine IL-1 beta as an immunological adjuvant by Andrews, A E, Lofthouse, S A, Bowles, V M, Brandon, M R, Nash, A D

“…To determine the potential of ovine interleukin 1 (IL-1) as a vaccine adjuvant in sheep, we have expressed and purified recombinant ovine IL-1 beta (rovIL-1…”
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Parameters related to the application of recombinant ovine interleukin-1β as an adjuvant by Lofthouse, Shari A., Andrews, Arna E., Barcham, Garry J., Nash, Andrew D.

“…This paper describes aspects of the safety and efficacy of recombinant ovine interleukin-1β (rovIL-1β) as an immunological adjuvant. A dose-response…”
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Recombinant cytokines as immunological adjuvants by Nash, A D, Lofthouse, S A, Barcham, G J, Jacobs, H J, Ashman, K, Meeusen, E N, Brandon, M R, Andrews, A E

“…This paper describes the bacterial expression and purification of bioactive recombinant ovine interleukin-2 (rovIL-2), interleukin-1 alpha (rovIL-1 alpha) and…”
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Sustained-release delivery systems and their application for endoparasite control in animals by Cardamone, Michael, Lee, Rogan P, Lucas, Jane C, Birks, Duncan V.A, O'Donoghue, Michael, Lofthouse, Shari A, Brandon, Mal R

“…A solid formulation of a potent anthelmintic macrocyclic lactone, moxidectin, was administered using a non-degradable delivery device to discharge the agent…”
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In vitro testing of a pulsatile delivery system and its in vivo application for immunisation against tetanus toxoid by Cardamone, Michael, Lofthouse, Shari A, Lucas, Jane C, Lee, Rogan P, O'Donoghue, Michael, Brandon, Mal R

“…Problems such as patient compliance and overdosing call for the development of pulsatile drug delivery devices. The in vitro and in vivo testing of a pulsatile…”
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King George III and porphyria: an elemental hypothesis and investigation by Cox, Timothy M, Jack, Nicola, Lofthouse, Simon, Watling, John, Haines, Janice, Warren, Martin J

“…In 1969 it was proposed that the episodic madness suffered by King George III (1738–1820) resulted from an acute hereditary porphyria, variegate porphyria,…”
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Cytokines as Adjuvants for Ruminant Vaccines by Lofthouse, S

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Manipulating the immune response; applications in livestock breeding by Lofthouse, Shari, Kemp, Joanna

“…There are many opportunities for the use of immune modulation techniques in livestock that offer the potential to reduce the requirements for chemical usage…”
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The Qijurittuq site (IbGk-3), Eastern Hudson Bay: An IPY Interdisciplinary Study by Desrosiers, Pierre M., Lofthouse, Susan, Bhiry, Najat, Lemieux, Anne-Marie, Monchot, Hervé, Gendron, Daniel, Marguerie, Dominique

“…Geografisk Tidsskrift-Danish Journal of Geography 110(2):227-243, 2010 An interdisciplinary study was conducted at Qijurittuq (IbGk-3), an archaeological site…”
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The application of biodegradable collagen minipellets as vaccine delivery vehicles in mice and sheep by Lofthouse, Shari, Nagahara, Shunji, Sedgmen, Bradley, Barcham, Garry, Brandon, Malcolm, Sano, Akihiko

“…Collagen minipellets are injectable delivery vehicles that release antigen and adjuvant over several days in a first-order release profile. In vaccination…”
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Oxidised mannan antigen conjugates preferentially stimulate T1 type immune responses by McKenzie, Ian F.C, Apostolopoulos, Vasso, Lees, Catherine, Xing, P.-X, Lofthouse, Shari, Osinski, Carla, Popovski, Violeta, Acres, Bruce, Pietersz, Geoff

“…It is desirable to be able to produce either T1 or T2 responses and we have found that, in mice, mannose - coupled antigens stimulated T2 type responses…”
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