Search Results - "Lofgren, Michael"

A switch III motif relays signaling between a B12 enzyme and its G-protein chaperone by Lofgren, Michael, Padovani, Dominique, Koutmos, Markos, Banerjee, Ruma

“…Heterotrimeric G proteins contain a switch III motif that regulates enzyme function. Structural and biochemical studies now identify a similar switch III loop…”
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Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations by McMillan, Brian J, Zimmerman, Brandon, Egan, Emily D, Lofgren, Michael, Xu, Xiang, Hesser, Anthony, Blacklow, Stephen C

“…Protein O-fucosyltransferase-1 (POFUT1), which transfers fucose residues to acceptor sites on serine and threonine residues of epidermal growth factor-like…”
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Autoinhibition and Signaling by the Switch II Motif in the G-protein Chaperone of a Radical B12 Enzyme by Lofgren, Michael, Koutmos, Markos, Banerjee, Ruma

“…MeaB is an accessory GTPase protein involved in the assembly, protection, and reactivation of 5′-deoxyadenosyl cobalamin-dependent methylmalonyl-CoA mutase…”
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Loss of Allostery and Coenzyme B12 Delivery by a Pathogenic Mutation in Adenosyltransferase by Lofgren, Michael, Banerjee, Ruma

“…ATP-dependent cob(I)alamin adenosyltransferase (ATR) is a bifunctional protein: an enzyme that catalyzes the adenosylation of cob(I)alamin and an escort that…”
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METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis by Liu, Shuo, Hausmann, Simone, Carlson, Scott Moore, Fuentes, Mary Esmeralda, Francis, Joel William, Pillai, Renjitha, Lofgren, Shane Michael, Hulea, Laura, Tandoc, Kristofferson, Lu, Jiuwei, Li, Ami, Nguyen, Nicholas Dang, Caporicci, Marcello, Kim, Michael Paul, Maitra, Anirban, Wang, Huamin, Wistuba, Ignacio Ivan, Porco, John Anthony, Bassik, Michael Cory, Elias, Joshua Eric, Song, Jikui, Topisirovic, Ivan, Van Rechem, Capucine, Mazur, Pawel Karol, Gozani, Or

“…Increased protein synthesis plays an etiologic role in diverse cancers. Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A…”
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Navigating the B12 Road: Assimilation, Delivery, and Disorders of Cobalamin by Gherasim, Carmen, Lofgren, Michael, Banerjee, Ruma

“…The reactivity of the cobalt-carbon bond in cobalamins is the key to their chemical versatility, supporting both methyl transfer and isomerization reactions…”
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Loss of Allostery and Coenzyme B 12 Delivery by a Pathogenic Mutation in Adenosyltransferase by Lofgren, Michael, Banerjee, Ruma

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Functional enhancement of mesothelin-targeted TRuC-T cells by a PD1-CD28 chimeric switch receptor by McCarthy, Derrick, Lofgren, Michael, Watt, Amy, Horton, Holly, Kieffer-Kwon, Philippe, Ding, Jian, Kobold, Sebastian, Baeuerle, Patrick A., Hofmeister, Robert, Gutierrez, Dario A., Tighe, Robert

“…T cells expressing a mesothelin (MSLN)-specific T cell receptor fusion construct (TRuC ® ), called TC-210, have demonstrated robust antitumor activity in…”
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Corruption of the Rotary Mechanism for Coenzyme B12 Delivery in Methylmalonic Aciduria by Lofgren, Michael, Banerjee, Ruma

“…The ATP‐dependent cob(I)alamin adenosyltransferase (ATR) is a bifunctional enzyme that catalyzes a reductive adenosylation of cob(II)alamin and then ferries…”
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Abstract 1528: Discovery and preclinical characterization of fratricide-resistant TRuC T-cells targeting CD70 by Ding, Jian, Watt, Amy, Liu, Erica, Adam, Zieba, McCarthy, Derrick, Gierut, Jessica, Schrand, Brett, Lofgren, Michael, Lajoie, Jason, Kenanova, Vania, Kiefer-Kwon, Philippe, Horton, Holly, Gutierrez, Dario A., Hofmeister, Robert, Tighe, Robert

“…Previously we have described the design and antitumor activity of T cell receptor fusion constructs (TRuC™) that tether an antibody-derived binder to one of…”
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Switch I-dependent allosteric signaling in a G-protein chaperone–B12 enzyme complex by Campanello, Gregory C., Lofgren, Michael, Yokom, Adam L., Southworth, Daniel R., Banerjee, Ruma

“…G-proteins regulate various processes ranging from DNA replication and protein synthesis to cytoskeletal dynamics and cofactor assimilation and serve as models…”
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Abstract 893: A chimeric PD1-CD28 switch receptor enhances the activity of TRuC-T cells by McCarthy, Derrick P., Guyette, Sarah, Lofgren, Michael, Sethuraman, Jyothi, DeSilva, Thamara, Aziz, Ahmar, Patterson, Troy, Datari, Shruti, Chan, Tiffany, Kieffer-Kwon, Philippe, Rold, Christopher J., Singh, Reshma, Ding, Jian, Horton, Holly, Barnitz, R. Anthony, Cornforth, Andrew, Tighe, Robert, Hofmeister, Robert J., Gutierrez, Dario A.

“…Cluster of differentiation 28 (CD28) and programmed death receptor 1 (PD-1) are members of the CD28 superfamily of co-receptors that have critical roles in the…”
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Switch I-dependent allosteric signaling in a G-protein chaperone-B 12 enzyme complex by Campanello, Gregory C, Lofgren, Michael, Yokom, Adam L, Southworth, Daniel R, Banerjee, Ruma

“…G-proteins regulate various processes ranging from DNA replication and protein synthesis to cytoskeletal dynamics and cofactor assimilation and serve as models…”
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Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin by Gherasim, Carmen, Lofgren, Michael, Banerjee, Ruma

“…The reactivity of the cobalt-carbon bond in cobalamins is the key to their chemical versatility, supporting both methyl transfer and isomerization reactions…”
Get full text