Search Results - "Loewenstein, Paul M"

Ad E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain by Zhao, Ling-Jun, Loewenstein, Paul M, Green, Maurice

“…Abstract The adenovirus E1A 243R oncoprotein targets TRRAP, a scaffold protein that assembles histone acetyltransferase (HAT) complexes, such as the NuA4/Tip60…”
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Adenovirus E1A TRRAP-targeting domain-mediated enhancement of MYC association with the NuA4 complex activates a panel of MYC target genes enriched for gene expression and ribosome biogenesis by Zhao, Ling-Jun, Loewenstein, Paul M., Green, Maurice

“…Cellular transformation by adenovirus E1A requires targeting TRRAP, a scaffold protein which helps assemble histone acetyltransferase complexes, including the…”
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Maurice Green – A pioneering virologist by Loewenstein, Paul M., Green, Eric D., Wold, William S.M.

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Enhanced MYC association with the NuA4 histone acetyltransferase complex mediated by the adenovirus E1A N-terminal domain activates a subset of MYC target genes highly expressed in cancer cells by Zhao, Ling-Jun, Loewenstein, Paul M, Green, Maurice

“…The proto-oncogene MYC is a transcription factor over-expressed in many cancers and required for cell survival. Its function is regulated by histone…”
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Identification of a panel of MYC and Tip60 co-regulated genes functioning primarily in cell cycle and DNA replication by Zhao, Ling-Jun, Loewenstein, Paul M, Green, Maurice

“…We recently reported that adenovirus E1A enhances MYC association with the NuA4/Tip60 histone acetyltransferase (HAT) complex to activate a panel of genes…”
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The adenoviral E1A N-terminal domain represses MYC transcription in human cancer cells by targeting both p300 and TRRAP and inhibiting MYC promoter acetylation of H3K18 and H4K16 by Zhao, Ling-Jun, Loewenstein, Paul M, Green, Maurice

“…Human cancers frequently arise from increased expression of proto-oncogenes, such as MYC and HER2. Understanding the cellular pathways regulating the…”
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The adenovirus E1A oncoprotein N-terminal transcriptional repression domain enhances p300 autoacetylation and inhibits histone H3 Lys18 acetylation by Zhao, Ling-Jun, Loewenstein, Paul M, Green, Maurice

“…Expression of the adenovirus E1A N-terminal transcription repression domain alone (E1A 1-80) represses transcription from specific promoters such as HER2 [1]…”
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Adenovirus E1A N-Terminal Amino Acid Sequence Requirements for Repression of Transcription In Vitro and In Vivo Correlate with Those Required for E1A Interference with TBP-TATA Complex Formation by Boyd, Janice M, Loewenstein, Paul M, Tang Qq, Qing-quan, Yu, Li, Green, Maurice

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The adenovirus E1A N-terminal repression domain represses transcription from a chromatin template in vitro by Loewenstein, Paul M, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Green, Maurice

“…Abstract The adenovirus repression domain of E1A 243R at the E1A N-terminus (E1A 1–80) transcriptionally represses genes involved in differentiation and cell…”
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Expression of the Adenovirus Early Gene 1A Transcription-Repression Domain Alone Downregulates HER2 and Results in the Death of Human Breast Cancer Cells Upregulated for the HER2 Proto-Oncogene by Loewenstein, Paul M, Green, Maurice

“…Adenovirus (Ad) early gene 1A 243 residue protein (E1A 243R) possesses a potent transcription-repression function within the N-terminal 80 amino acids (E1A…”
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Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein by Green, M, Loewenstein, P M

“…HIV-1 encodes a potent trans-activator protein, tat, which is essential for viral gene expression. To study tat domains that function in trans-activation, we…”
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Mutational and functional analysis of an essential subdomain of the adenovirus E1A N-terminal transcription repression domain by Loewenstein, Paul M., Arackal, Sophia, Green, Maurice

“…Adenovirus early gene 1A (E1A) possesses a potent transcriptional repression function within the first 80 amino acids (E1A 1–80). Our previous analysis of…”
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Adenovirus E1A proteins are closely associated with chromatin in productively infected and transformed cells by Green, Maurice, Panesar, Ninder K, Loewenstein, Paul M

“…Abstract The adenovirus E1A 243R oncoprotein encodes a potent transcription-repression function within the N-terminal 80 amino acids. Our proposed model of E1A…”
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Human adenoviruses: propagation, purification, quantification, and storage by Green, Maurice, Loewenstein, Paul M

“…Detailed protocols are described for the propagation of adenoviruses (Ads) and adenovirus (Ad) vectors and their purification by CsCl equilibrium density…”
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The use of cell microinjection for the in vivo analysis of viral transcriptional regulatory protein domains by Green, Maurice, Thorburn, Andrew, Kern, Robert, Loewenstein, Paul M

“…Microinjection of mammalian cells provides a powerful method for analyzing in vivo functions of viral genes and viral gene products. By microinjection, a…”
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The use of in vitro transcription to probe regulatory functions of viral protein domains by Loewenstein, Paul M, Song, Chao-Zhong, Green, Maurice

“…Adenoviruses (Ads), like other DNA tumor viruses, have evolved specific regulatory genes that facilitate virus replication by controlling the transcription of…”
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αAd E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain by Zhao, Ling-Jun, Loewenstein, Paul M., Green, Maurice

“…The adenovirus E1A 243R oncoprotein targets TRRAP, a scaffold protein that assembles histone acetyltransferase (HAT) complexes, such as the NuA4/Tip60 complex…”
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Transcription Factor TFIID is a Direct Functional Target of the Adenovirus E1A Transcription-Repression Domain by Song, Chao-Zhong, Loewenstein, Paul M., Toth, Karoly, Green, Maurice

“…The 243-amino acid adenovirus E1A oncoprotein both positively and negatively modulates the expression of cellular genes involved in the regulation of cell…”
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Transcriptional Repression by Human Adenovirus E1A N Terminus/Conserved Domain 1 Polypeptides in Vivo and in Vitro in the Absence of Protein Synthesis (∗) by Song, Chao-Zhong, Tierney, Christopher J., Loewenstein, Paul M., Pusztai, Rozalia, Symington, Janey S., Tang, Qing-quan, Toth, Karoly, Nishikawa, Akira, Bayley, Stanley T., Green, Maurice

“…The human adenovirus E1A 243R protein (243 residues) transcriptionally represses a set of cellular genes that regulate cellular growth and differentiation. We…”
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Detection of reverse transcriptase in human breast tumours with poly(Cm)·oligo(dG) by GERARD, GARY F, LOEWENSTEIN, PAUL M, GREEN, MAURICE, ROTTMAN, FRITZ

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