Search Results - "Loewe, Axel"

Corrigendum: A review of healthy and fibrotic myocardium microstructure modeling and corresponding intracardiac electrograms by Sánchez, Jorge, Loewe, Axel

“…[This corrects the article DOI: 10.3389/fphys.2022.908069.]…”
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A Review of Healthy and Fibrotic Myocardium Microstructure Modeling and Corresponding Intracardiac Electrograms by Sánchez, Jorge, Loewe, Axel

“…Computational simulations of cardiac electrophysiology provide detailed information on the depolarization phenomena at different spatial and temporal scales…”
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The openCARP simulation environment for cardiac electrophysiology by Plank, Gernot, Loewe, Axel, Neic, Aurel, Augustin, Christoph, Huang, Yung-Lin, Gsell, Matthias A.F., Karabelas, Elias, Nothstein, Mark, Prassl, Anton J., Sánchez, Jorge, Seemann, Gunnar, Vigmond, Edward J.

“…•We present the openCARP simulation environment as a solution that could foster the needs of large parts of the computational cardiac electrophysiology…”
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A Reproducible Protocol to Assess Arrhythmia Vulnerability in silico : Pacing at the End of the Effective Refractory Period by Azzolin, Luca, Schuler, Steffen, Dössel, Olaf, Loewe, Axel

“…In both clinical and computational studies, different pacing protocols are used to induce arrhythmia and non-inducibility is often considered as the endpoint…”
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The Impact of Standard Ablation Strategies for Atrial Fibrillation on Cardiovascular Performance in a Four-Chamber Heart Model by Gerach, Tobias, Schuler, Steffen, Wachter, Andreas, Loewe, Axel

“…Purpose Atrial fibrillation is one of the most frequent cardiac arrhythmias in the industrialized world and ablation therapy is the method of choice for many…”
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A Fully-Coupled Electro-Mechanical Whole-Heart Computational Model: Influence of Cardiac Contraction on the ECG by Moss, Robin, Wülfers, Eike Moritz, Schuler, Steffen, Loewe, Axel, Seemann, Gunnar

“…The ECG is one of the most commonly used non-invasive tools to gain insights into the electrical functioning of the heart. It has been crucial as a foundation…”
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Specific Electrogram Characteristics Identify the Extra-Pulmonary Vein Arrhythmogenic Sources of Persistent Atrial Fibrillation – Characterization of the Arrhythmogenic Electrogram Patterns During Atrial Fibrillation and Sinus Rhythm by Jadidi, Amir, Nothstein, Mark, Chen, Juan, Lehrmann, Heiko, Dössel, Olaf, Allgeier, Jürgen, Trenk, Dietmar, Neumann, Franz-Josef, Loewe, Axel, Müller-Edenborn, Björn, Arentz, Thomas

“…Identification of atrial sites that perpetuate atrial fibrillation (AF), and ablation thereof terminates AF, is challenging. We hypothesized that specific…”
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Commentary: Virtual In-Silico Modeling Guided Catheter Ablation Predicts Effective Linear Ablation Lesion Set for Longstanding Persistent Atrial Fibrillation: Multicenter Prospective Randomized Study by Loewe, Axel, Dössel, Olaf

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Causes of altered ventricular mechanics in hypertrophic cardiomyopathy: an in-silico study by Kovacheva, Ekaterina, Gerach, Tobias, Schuler, Steffen, Ochs, Marco, Dössel, Olaf, Loewe, Axel

“…Hypertrophic cardiomyopathy (HCM) is typically caused by mutations in sarcomeric genes leading to cardiomyocyte disarray, replacement fibrosis, impaired…”
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Comparison of Unipolar and Bipolar Voltage Mapping for Localization of Left Atrial Arrhythmogenic Substrate in Patients With Atrial Fibrillation by Nairn, Deborah, Lehrmann, Heiko, Müller-Edenborn, Björn, Schuler, Steffen, Arentz, Thomas, Dössel, Olaf, Jadidi, Amir, Loewe, Axel

“…Presence of left atrial low voltage substrate in bipolar voltage mapping is associated with increased arrhythmia recurrences following pulmonary vein isolation…”
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Electro-Mechanical Whole-Heart Digital Twins: A Fully Coupled Multi-Physics Approach by Gerach, Tobias, Schuler, Steffen, Fröhlich, Jonathan, Lindner, Laura, Kovacheva, Ekaterina, Moss, Robin, Wülfers, Eike Moritz, Seemann, Gunnar, Wieners, Christian, Loewe, Axel

“…Mathematical models of the human heart are evolving to become a cornerstone of precision medicine and support clinical decision making by providing a powerful…”
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Patient-Specific Identification of Atrial Flutter Vulnerability-A Computational Approach to Reveal Latent Reentry Pathways by Loewe, Axel, Poremba, Emanuel, Oesterlein, Tobias, Luik, Armin, Schmitt, Claus, Seemann, Gunnar, Dössel, Olaf

“…Atypical atrial flutter (AFlut) is a reentrant arrhythmia which patients frequently develop after ablation for atrial fibrillation (AF). Indeed, substrate…”
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The reverse mode of the Na+/Ca2+ exchanger contributes to the pacemaker mechanism in rabbit sinus node cells by Tóth, Noémi, Loewe, Axel, Szlovák, Jozefina, Kohajda, Zsófia, Bitay, Gergő, Levijoki, Jouko, Papp, Julius Gy, Varró, András, Nagy, Norbert

“…Sinus node (SN) pacemaking is based on a coupling between surface membrane ion-channels and intracellular Ca 2+ -handling. The fundamental role of the inward…”
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Editorial: Atrial Fibrillation: Technologies for Investigation, Monitoring and Treatment, Volume II by Berenfeld, Omer, Corino, Valentina, Loewe, Axel, Martínez, Juan Pablo, Rodriguez Matas, Jose F

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Using Machine Learning to Characterize Atrial Fibrotic Substrate From Intracardiac Signals With a Hybrid in silico and in vivo Dataset by Sánchez, Jorge, Luongo, Giorgio, Nothstein, Mark, Unger, Laura A, Saiz, Javier, Trenor, Beatriz, Luik, Armin, Dössel, Olaf, Loewe, Axel

“…In patients with atrial fibrillation, intracardiac electrogram signal amplitude is known to decrease with increased structural tissue remodeling, referred to…”
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Functional Characterization of a Spectrum of Novel Romano-Ward Syndrome KCNQ1 Variants by Rinné, Susanne, Oertli, Annemarie, Nagel, Claudia, Tomsits, Philipp, Jenewein, Tina, Kääb, Stefan, Kauferstein, Silke, Loewe, Axel, Beckmann, Britt Maria, Decher, Niels

“…The gene encodes the α-subunit of the cardiac voltage-gated potassium (Kv) channel KCNQ1, also denoted as Kv7.1 or KvLQT1. The channel assembles with the…”
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Impact of the Right Atrium on Arrhythmia Vulnerability by Fitzen, Nikola André, Martínez Díaz, Patricia, Dössel, Olaf, Loewe, Axel

“…Atrial fibrillation (AF) is one of the most common cardiac diseases. However, a complete understanding of how to treat patients suffering from AF is still not…”
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An automate pipeline for generating fiber orientation and region annotation in patient specific atrial models by Zheng, Tianbao, Azzolin, Luca, Sánchez, Jorge, Dössel, Olaf, Loewe, Axel

“…Modeling the 'digital twin' of a patient's heart has gained traction in the last years and helps to understand the pathogenic mechanisms of cardiovascular…”
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PTB-XL+, a comprehensive electrocardiographic feature dataset by Strodthoff, Nils, Mehari, Temesgen, Nagel, Claudia, Aston, Philip J., Sundar, Ashish, Graff, Claus, Kanters, Jørgen K., Haverkamp, Wilhelm, Dössel, Olaf, Loewe, Axel, Bär, Markus, Schaeffter, Tobias

“…Machine learning (ML) methods for the analysis of electrocardiography (ECG) data are gaining importance, substantially supported by the release of large public…”
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Dyssynchronous Left Ventricular Activation is Insufficient for the Breakdown of Wringing Rotation by Gerach, Tobias, Appel, Stephanie, Wilczek, Jacek, Golba, Krzysztof S, Jadczyk, Tomasz, Loewe, Axel

“…Cardiac resynchronization therapy is a valuable tool to restore left ventricular function in patients experiencing dyssynchronous ventricular activation…”
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