Search Results - "Loeschmann, Nadine"

Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen by Michaelis, Martin, Agha, Bishr, Rothweiler, Florian, Löschmann, Nadine, Voges, Yvonne, Mittelbronn, Michel, Starzetz, Tatjana, Harter, Patrick N., Abhari, Behnaz A., Fulda, Simone, Westermann, Frank, Riecken, Kristoffer, Spek, Silvia, Langer, Klaus, Wiese, Michael, Dirks, Wilhelm G., Zehner, Richard, Cinatl, Jaroslav, Wass, Mark N., Cinatl, Jindrich

“…Flubendazole was shown to exert anti-leukaemia and anti-myeloma activity through inhibition of microtubule function. Here, flubendazole was tested for its…”
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Aurora kinases as targets in drug-resistant neuroblastoma cells by Michaelis, Martin, Selt, Florian, Rothweiler, Florian, Löschmann, Nadine, Nüsse, Benedikt, Dirks, Wilhelm G, Zehner, Richard, Cinatl, Jr, Jindrich

“…Aurora kinase inhibitors displayed activity in pre-clinical neuroblastoma models. Here, we studied the effects of the pan-aurora kinase inhibitor tozasertib…”
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multi-targeted kinase inhibitor sorafenib inhibits human cytomegalovirus replication by Michaelis, Martin, Paulus, Christina, Löschmann, Nadine, Dauth, Stephanie, Stange, Elisabeth, Doerr, Hans Wilhelm, Nevels, Michael, Cinatl, Jindrich Jr

“…Human cytomegalovirus (HCMV) is a major pathogen in immunocompromised individuals. Here, non-toxic concentrations of the anti-cancer kinase inhibitor sorafenib…”
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Enzastaurin inhibits ABCB1-mediated drug efflux independently of effects on protein kinase C signalling and the cellular p53 status by Michaelis, Martin, Rothweiler, Florian, Löschmann, Nadine, Sharifi, Mohsen, Ghafourian, Taravat, Cinatl, Jr, Jindrich

“…The PKCβ inhibitor enzastaurin was tested in parental neuroblastoma and rhabdomyosarcoma cell lines, their vincristine-resistant sub-lines, primary…”
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ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance by Löschmann, Nadine, Michaelis, Martin, Rothweiler, Florian, Voges, Yvonne, Balónová, Barbora, Blight, Barry A, Cinatl, Jr, Jindrich

“…The CDK inhibitor SNS-032 had previously exerted promising anti-neuroblastoma activity via CDK7 and 9 inhibition. ABCB1 expression was identified as major…”
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The anti-tumoral drug enzastaurin inhibits natural killer cell cytotoxicity via activation of glycogen synthase kinase-3β by Ogbomo, Henry, Biru, Tsigereda, Michaelis, Martin, Loeschmann, Nadine, Doerr, Hans Wilhelm, Cinatl, Jindrich

“…Enzastaurin is a selective protein kinase Cβ inhibitor which is shown to have direct antitumor effect as well as suppress glycogen synthase kinase-3β (GSK-3β)…”
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Testing of SNS-032 in a Panel of Human Neuroblastoma Cell Lines with Acquired Resistance to a Broad Range of Drugs by Löschmann, Nadine, Michaelis, Martin, Rothweiler, Florian, Zehner, Richard, Cinatl, Jaroslav, Voges, Yvonne, Sharifi, Mohsen, Riecken, Kristoffer, Meyer, Jochen, von Deimling, Andreas, Fichtner, Iduna, Ghafourian, Taravat, Westermann, Frank, Cinatl, Jindrich

“…Novel treatment options are needed for the successful therapy of patients with high-risk neuroblastoma. Here, we investigated the cyclin-dependent kinase (CDK)…”
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