Search Results - "Loesch, Kimberly A."

Structure-Guided Drug Design of 6‑Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase by Crespo, Roberto A, Dang, Qun, Zhou, Nian E, Guthrie, Liam M, Snavely, Thomas C, Dong, Wen, Loesch, Kimberly A, Suzuki, Takao, You, Lanying, Wang, Wei, O’Malley, Theresa, Parish, Tanya, Olsen, David B, Sacchettini, James C

“…Mycobacterium tuberculosis adenosine kinase (MtbAdoK) is an essential enzyme of Mtb and forms part of the purine salvage pathway within mycobacteria. Evidence…”
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Agonist-Biased Signaling at the sst2A Receptor: The Multi-Somatostatin Analogs KE108 and SOM230 Activate and Antagonize Distinct Signaling Pathways by Cescato, Renzo, Loesch, Kimberly A, Waser, Beatrice, Mäcke, Helmut R, Rivier, Jean E, Reubi, Jean Claude, Schonbrunn, Agnes

“…Somatostatin analogs that activate the somatostatin subtype 2A (sst2A) receptor are used to treat neuroendocrine cancers because they inhibit tumor secretion…”
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Mycobacterium Cytidylate Kinase Appears to Be an Undruggable Target by Craig, Justin K, Risler, Jenni K, Loesch, Kimberly A, Dong, Wen, Baker, Dwight, Barrett, Lynn K, Subramanian, Sandhya, Samudrala, Ram, Van Voorhis, Wesley C

“…New and improved drugs against tuberculosis are urgently needed as multi-drug-resistant forms of the disease become more prevalent. Mycobacterium tuberculosis…”
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HIV-Induced TNF-α Regulates Arachidonic Acid and PGE2 Release from HIV-Infected Mononuclear Phagocytes by Nokta, Mostafa A., Hassan, Mahmoud I., Loesch, Kimberly A., Pollard, Richard B.

“…Arachidonic acid (AA) has been shown to interact with transmembrane signaling pathways involved in T-cell activation. The latter have been shown to be impaired…”
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