Search Results - "Loerch, Sarah"

Unmasking the U2AF homology motif family: a bona fide protein-protein interaction motif in disguise by Loerch, Sarah, Kielkopf, Clara L

“…U2AF homology motifs (UHM) that recognize U2AF ligand motifs (ULM) are an emerging family of protein-protein interaction modules. UHM-ULM interactions recur in…”
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Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids by Liberta, Falk, Loerch, Sarah, Rennegarbe, Matthies, Schierhorn, Angelika, Westermark, Per, Westermark, Gunilla T., Hazenberg, Bouke P. C., Grigorieff, Nikolaus, Fändrich, Marcus, Schmidt, Matthias

“…Systemic AA amyloidosis is a worldwide occurring protein misfolding disease of humans and animals. It arises from the formation of amyloid fibrils from the…”
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In situ single particle classification reveals distinct 60S maturation intermediates in cells by Lucas, Bronwyn A, Zhang, Kexin, Loerch, Sarah, Grigorieff, Nikolaus

“…Previously, we showed that high-resolution template matching can localize ribosomes in two-dimensional electron cryo-microscopy (cryo-EM) images of untilted…”
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mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding by Bao, Chen, Loerch, Sarah, Ling, Clarence, Korostelev, Andrei A, Grigorieff, Nikolaus, Ermolenko, Dmitri N

“…Although the elongating ribosome is an efficient helicase, certain mRNA stem-loop structures are known to impede ribosome movement along mRNA and stimulate…”
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Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance by Smith, Patrick R., Loerch, Sarah, Kunder, Nikesh, Stanowick, Alexander D., Lou, Tzu-Fang, Campbell, Zachary T.

“…Processing bodies (p-bodies) are a prototypical phase-separated RNA-containing granule. Their abundance is highly dynamic and has been linked to translation…”
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Identifying Inhibitors of -1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses by Munshi, Sneha, Neupane, Krishna, Ileperuma, Sandaru M, Halma, Matthew T J, Kelly, Jamie A, Halpern, Clarissa F, Dinman, Jonathan D, Loerch, Sarah, Woodside, Michael T

“…Recurrent outbreaks of novel zoonotic coronavirus (CoV) diseases in recent years have highlighted the importance of developing therapeutics with broad-spectrum…”
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Protocol for the isolation and culture of mouse dorsal root ganglion neurons for imaging applications by Smith, Patrick R., Meyer, Angela, Loerch, Sarah, Campbell, Zachary T.

“…Sensory neurons play pervasive roles throughout biology. In vitro studies to probe their functions hinge on the successful application of primary cell culture…”
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Recent advances and current trends in cryo-electron microscopy by Guaita, Margherita, Watters, Scott C., Loerch, Sarah

“…All steps of cryogenic electron-microscopy (cryo-EM) workflows have rapidly evolved over the last decade. Advances in both single-particle analysis (SPA)…”
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Role of the U2AF Homology Motif in Human Tat‐SF1 as a Cofactor for HIV‐1 Splicing by Loerch, Sarah, Kielkopf, Clara

“…Abstract only The HIV‐1 life cycle relies on controlled ratios of unspliced and alternatively spliced mRNAs. Human Tat‐SF1 is a requisite host factor for the…”
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Sleeping Beauty redux – resting ribosomes in neurons by Loerch, Sarah, Smith, Patrick R., Campbell, Zachary T., Petrossian, Edward

“…Abstract only…”
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The space between notes: emerging roles for translationally silent ribosomes by Smith, Patrick R., Pandit, Sapna C., Loerch, Sarah, Campbell, Zachary T.

“…In addition to their central functions in translation, ribosomes can adopt inactive structures that are fully assembled yet devoid of mRNA. We describe how the…”
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Dividing and Conquering the RNA Recognition Motif Family: A Representative Case Based on hnRNP L by Loerch, Sarah, Kielkopf, Clara L.

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Investigating the role of SERBP1 in translation by Guaita, Margherita, Maya, Jax I., Smith, Patrick R., Campbell, Zachary T., Loerch, Sarah

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Dividing and Conquering the Family of RNA Recognition Motifs: A Representative Case Based on hnRNP L by Loerch, Sarah, Kielkopf, Clara L.

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A UHM-ULM interface contributes to the pre-mRNA splicing functions of U2AF2 and SF3B1 by Galardi, Justin W., Bela, Victoria N., Jeffery, Nazish N., Glasser, Eliezra, Loerch, Sarah, Jenkins, Jermaine L., Pulvino, Mary J., Kielkopf, Clara L.

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The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface by Loerch, Sarah, Leach, Justin R., Horner, Steven W., Maji, Debanjana, Jenkins, Jermaine L., Pulvino, Mary J., Kielkopf, Clara L.

“…The transcription elongation and pre-mRNA splicing factor Tat-SF1 associates with the U2 small nuclear ribonucleoprotein (snRNP) of the spliceosome. However,…”
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Cancer-relevant Splicing Factor CAPERα Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex by Loerch, Sarah, Maucuer, Alexandre, Manceau, Valérie, Green, Michael R., Kielkopf, Clara L.

“…U2AF homology motifs (UHMs) mediate protein-protein interactions with U2AF ligand motifs (ULMs) of pre-mRNA splicing factors. The UHM-containing alternative…”
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Intercellular Arc Signaling Regulates Vasodilation by de la Peña, June Bryan, Barragan-Iglesias, Paulino, Lou, Tzu-Fang, Kunder, Nikesh, Loerch, Sarah, Shukla, Tarjani, Basavarajappa, Lokesh, Song, Jane, James, Dominique N, Megat, Salim, Moy, Jamie K, Wanghzou, Andi, Ray, Pradipta R, Hoyt, Kenneth, Steward, Oswald, Price, Theodore J, Shepherd, Jason, Campbell, Zachary T

“…Injury responses require communication between different cell types in the skin. Sensory neurons contribute to inflammation and can secrete signaling molecules…”
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A UHM–ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing by Galardi, Justin W., Bela, Victoria N., Jeffery, Nazish, He, Xueyang, Glasser, Eliezra, Loerch, Sarah, Jenkins, Jermaine L., Pulvino, Mary J., Boutz, Paul L., Kielkopf, Clara L.

“…During spliceosome assembly, the 3′ splice site is recognized by sequential U2AF2 complexes, first with Splicing Factor 1 (SF1) and second by the SF3B1 subunit…”
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SF1 Phosphorylation Enhances Specific Binding to U2AF^sup 65^ and Reduces Binding to 3'-Splice-Site RNA by Chatrikhi, Rakesh, Wang, Wenhua, Gupta, Ankit, Loerch, Sarah, Maucuer, Alexandre, Kielkopf, Clara L

“…Splicing factor 1 (SF1) recognizes 3' splice sites of the major class of introns as a ternary complex with U2AF^sup 65^ and U2AF^sup 35^ splicing factors. A…”
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