Search Results - "Loepke, Andreas"

Cognition and Brain Structure Following Early Childhood Surgery With Anesthesia by Backeljauw, Barynia, Holland, Scott K, Altaye, Mekibib, Loepke, Andreas W

“…Anesthetics induce widespread cell death, permanent neuronal deletion, and neurocognitive impairment in immature animals, raising substantial concerns about…”
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An Assessment of the Effects of General Anesthetics on Developing Brain Structure and Neurocognitive Function by Loepke, Andreas W., Soriano, Sulpicio G.

“…Neuronal cell death after general anesthesia has recently been documented in several immature animal models. Worldwide, volatile anesthetics are used in…”
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Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies by Lin, Erica P., MD, Lee, Jeong-Rim, MD, PhD, Lee, Christopher S., MD, Deng, Meng, MD, PhD, Loepke, Andreas W., MD, PhD

“…Abstract Anesthetics permit surgical procedures and stressful interventions have been found to cause structural brain abnormalities and functional impairment…”
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Comparison of the Neuroapoptotic Properties of Equipotent Anesthetic Concentrations of Desflurane, Isoflurane, or Sevoflurane in Neonatal Mice by ISTAPHANOUS, George K, HOWARD, Jennifer, XINYU NAN, HUGHES, Elizabeth A, MCCANN, John C, MCAULIFFE, John J, DANZER, Steve C, LOEPKE, Andreas W

“…Volatile anesthetics facilitate surgical procedures and imaging studies in millions of children every year. Neuronal cell death after prolonged exposure to…”
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Developmental neurotoxicity of sedatives and anesthetics: a concern for neonatal and pediatric critical care medicine? by Loepke, Andreas W

“…To evaluate the currently available evidence for the deleterious effects of sedatives and anesthetics on developing brain structure and neurocognitive…”
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Cell age-specific vulnerability of neurons to anesthetic toxicity by Hofacer, Rylon D., Deng, Meng, Ward, Christopher G., Joseph, Bernadin, Hughes, Elizabeth A., Jiang, Connie, Danzer, Steve C., Loepke, Andreas W.

“…Objective Anesthetics have been linked to widespread neuronal cell death in neonatal animals. Epidemiological human studies have associated early childhood…”
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Anesthesia and sedation exposure and neurodevelopmental outcomes in infants undergoing congenital cardiac surgery: a retrospective cohort study by Simpao, Allan F., Randazzo, Isabel R., Chittams, Jesse L., Burnham, Nancy, Gerdes, Marsha, Bernbaum, Judith C., Walker, Tia, Imsdahl, Solveig, DeWitt, Aaron G., Zackai, Elaine H., Gaynor, J. William, Loepke, Andreas W.

“…Children undergoing complex cardiac surgery are exposed to substantial cumulative doses of sedative medications and volatile anesthetics and are more…”
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Anesthesia and the developing brain: A way forward for laboratory and clinical research by Disma, Nicola, O'Leary, James D., Loepke, Andreas W., Brambrink, Ansgar M., Becke, Karin, Clausen, Nicola G., De Graaff, Jurgen C., Liu, Fang, Hansen, Tom G., McCann, Mary E., Salorio, Cynthia F., Soriano, Sulpicio, Sun, Lena S., Szmuk, Peter, Warner, David O., Vutskits, Laszlo, Davidson, Andrew J.

“…Summary All commonly used general anesthetics have been shown to cause neurotoxicity in animal models, including nonhuman primates. Opinion, however, remains…”
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Cutting the Gordian Knot That Ties Intraoperative Conditions to Long-term Neurodevelopmental Outcomes in Children Undergoing Congenital Heart Surgery by Yuan, Ian, Gaynor, J. William, Licht, Daniel J., Loepke, Andreas W.

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Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion statement from the SmartTots preclinical working group by Chinn, Gregory A, Pearn, Matthew L, Vutskits, Laszlo, Mintz, Cyrus D, Loepke, Andreas W, Lee, Jennifer J, Chen, Jerri, Bosnjak, Zeljko J, Brambrink, Ansgar M, Jevtovic-Todorovic, Vesna, Sun, Lena S, Sall, Jeffrey W

“…In March 2019, SmartTots, a public-private partnership between the US Food and Drug Administration and the International Anesthesia Research Society, hosted a…”
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General anesthetics and the developing brain by Istaphanous, George K, Loepke, Andreas W

“…General anesthetics and sedatives are used in millions of children every year to facilitate surgical procedures, imaging studies, and sedation in operating…”
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Characterization and Quantification of Isoflurane-Induced Developmental Apoptotic Cell Death in Mouse Cerebral Cortex by Istaphanous, George K., Ward, Christopher G., Nan, Xinyu, Hughes, Elizabeth A., McCann, John C., McAuliffe, John J., Danzer, Steve C., Loepke, Andreas W.

“…Accumulating evidence indicates that isoflurane and other, similarly acting anesthetics exert neurotoxic effects in neonatal animals. However, neither the…”
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Anesthetic Neurotoxicity by Lin, Erica P., MD, Soriano, Sulpicio G., MD, Loepke, Andreas W., MD, PhD

“…All routinely utilized sedatives and anesthetics have been found neurotoxic in a wide variety of animal species, including non-human primates. Neurotoxic…”
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The Effects of Neonatal Isoflurane Exposure in Mice on Brain Cell Viability, Adult Behavior, Learning, and Memory by Loepke, Andreas W., Istaphanous, George K., McAuliffe, John J., Miles, Lili, Hughes, Elizabeth A., McCann, John C., Harlow, Kathryn E., Kurth, C Dean, Williams, Michael T., Vorhees, Charles V., Danzer, Steve C.

“…Volatile anesthetics, such as isoflurane, are widely used in infants and neonates. Neurodegeneration and neurocognitive impairment after exposure to…”
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Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity by Jiang, Yifei, Tong, Dongyi, Hofacer, Rylon D, Loepke, Andreas W, Lian, Qingquan, Danzer, Steve C

“…BACKGROUND:Exposure to isoflurane increases apoptosis among postnatally generated hippocampal dentate granule cells. These neurons play important roles in…”
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What lessons for clinical practice can be learned from systematic reviews of animal studies? The case of anesthetic neurotoxicity by Loepke, Andreas W., Vutskits, Laszlo

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Does pediatric anesthesia cause brain damage? - Addressing parental and provider concerns in light of compelling animal studies and seemingly ambivalent human data by Lee, Jeong-Rim, Loepke, Andreas W

“…Anesthesia facilitates surgery in millions of young children every year. Structural brain abnormalities and functional impairment observed in animals have…”
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Dosing and efficacy of intranasal dexmedetomidine sedation for pediatric transthoracic echocardiography: a retrospective study by Miller, Jeffrey W., Divanovic, Allison A., Hossain, Md M., Mahmoud, Mohamed A., Loepke, Andreas W.

“…Purpose We designed this retrospective observational study on the use of α 2 -agonist dexmedetomidine to determine the optimum intranasal dose to achieve…”
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Cerebral Oxygen Saturation-Time Threshold for Hypoxic-Ischemic Injury in Piglets by Kurth, C Dean, McCann, John C., Wu, Jun, Miles, Lili, Loepke, Andreas W.

“…Detection of cerebral hypoxia-ischemia (H-I) and prevention of brain injury remains problematic in critically ill neonates. Near-infrared spectroscopy (NIRS),…”
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Clinical research into anesthetic neurotoxicity: does anesthesia cause neurological abnormalities in humans? by Lei, Susan Y, Hache, Manon, Loepke, Andreas W

“…General anesthetics mitigate distress and exaggerated hemodynamic responses to pain and stressful stimulation, allowing surgery and diagnostic procedures to be…”
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