Search Results - "Loehning, M"

TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine by Pascual-Reguant, A, Bayat Sarmadi, J, Baumann, C, Noster, R, Cirera-Salinas, D, Curato, C, Pelczar, P, Huber, S, Zielinski, C E, Löhning, M, Hauser, A E, Esplugues, E

“…T H 17 cells are major drivers of inflammation and involved in several autoimmune diseases. Tissue inflammation is a beneficial host response to infection, but…”
Get full text

T-bet expression by Th cells promotes type 1 inflammation but is dispensable for colitis by Zimmermann, J, Kühl, A A, Weber, M, Grün, J R, Löffler, J, Haftmann, C, Riedel, R, Maschmeyer, P, Lehmann, K, Westendorf, K, Mashreghi, M-F, Löhning, M, Mack, M, Radbruch, A, Chang, H D

“…The transcription factor T-bet is highly expressed by Th cells isolated from the inflamed intestine of Crohn’s disease patients, and has been regarded a…”
Get full text

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment by Ouyang, W, Löhning, M, Gao, Z, Assenmacher, M, Ranganath, S, Radbruch, A, Murphy, K M

“…The initial source of IL-4-inducing Th2 development and the mechanism of stable Th2 commitment remain obscure. We found the reduced level of IL-4 production in…”
Get full text

Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression by Richter, A, Löhning, M, Radbruch, A

“…T helper (Th) lymphocytes, when reactivated, recall expression of those cytokines they had been instructed to express in earlier activations, even in the…”
Get full text

P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues by Austrup, Frank, Vestweber, Dietmar, Borges, Eric, Löhning, Max, Bräuer, Rolf, Herz, Udo, Renz, Harald, Hallmann, Rupert, Scheffold, Alexander, Radbruch, Andreas, Hamann, Alf

“…When activated, T helper cells differentiate into one of two subsets, Th1 and Th2, characterized by distinct profiles of cytokine production. Th1 cells…”
Get full text

T1/ST2 is Preferentially Expressed on Murine Th2 Cells, Independent of Interleukin 4, Interleukin 5, and Interleukin 10, and Important for Th2 Effector Function by Lohning, Max, Stroehmann, Arne, Coyle, Anthony J., Grogan, Jane L., Lin, Steven, Gutierrez-Ramos, Jose-Carlos, Levinson, Douglas, Radbruch, Andreas, Kamradt, Thomas

“…T helper (Th) cells can be categorized according to their cytokine expression. The differential induction of Th cells expressing Th1 and/or Th2 cytokines is…”
Get full text

Cytokine memory of T helper lymphocytes by Löhning, Max, Richter, Anne, Radbruch, Andreas

“…Memory is one of the key features of the adaptive immune system. Specific T and B lymphocytes are primed for a particular antigen and upon challenge with it…”
Get more information

Survival of long-lived plasma cells is independent of antigen by Manz, R A, Löhning, M, Cassese, G, Thiel, A, Radbruch, A

“…Recent studies have shown that persistent specific antibody titer is provided by long-lived plasma cells (PC) which constitute a new kind of 'memory-providing…”
Get full text

Professional Memory CD4 super(+) T Lymphocytes Preferentially Reside and Rest in the Bone Marrow by Tokoyoda, K, Zehentmeier, S, Hegazy, AN, Albrecht, I, Gruen, J R, Loehning, M, Radbruch, A

“…CD4 super(+) T lymphocytes are key to immunological memory. Here we show that in the memory phase of specific immune responses, most of the memory CD4 super(+)…”
Get full text

GATA-3 Transcriptional Imprinting in Th2 Lymphocytes: A Mathematical Model by Höfer, Thomas, Nathansen, Holger, Löhning, Max, Radbruch, Andreas, Heinrich, Reinhart

“…Immunological memory involves the fast recall of cytokine expression by T helper (Th) lymphocytes. Two distinct profiles of cytokine expression, Th1 and Th2,…”
Get full text

An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3 by Farrar, J D, Ouyang, W, Löhning, M, Assenmacher, M, Radbruch, A, Kanagawa, O, Murphy, K M

“…Although interleukin (IL)-12 and IL-4 polarize naive CD4(+) T cells toward T helper cell type 1 (Th1) or Th2 phenotypes, it is not known whether cytokines…”
Get full text

Sequential production of IL‐2, IFN‐γ and IL‐10 by individual staphylococcal enterotoxin B‐activated T helper lymphocytes by Assenmacher, Mario, Löhning, Max, Scheffold, Alexander, Manz, Rudolf A., Schmitz, Jürgen, Radbruch, Andreas

“…Upon primary activation, T helper (Th) cell populations express different cytokines transiently and with different kinetics. Stimulation of naive murine…”
Get full text

Establishment of Memory for IL-10 Expression in Developing T Helper 2 Cells Requires Repetitive IL-4 Costimulation and Does Not Impair Proliferation by Löhning, Max, Richter, Anne, Stamm, Torsten, Hu-Li, Jane, Assenmacher, Mario, Paul, William E., Radbruch, Andreas

“…T helper (Th) lymphocytes can develop memory for the expression of particular cytokines, like IL-4 or IL-10, in that reexpression of those cytokines is…”
Get full text

Commitment of individual Th1-like lymphocytes to expression of IFN-gamma versus IL-4 and IL-10: selective induction of IL-10 by sequential stimulation of naive Th cells with IL-12 and IL-4 by Assenmacher, M, Löhning, M, Scheffold, A, Richter, A, Miltenyi, S, Schmitz, J, Radbruch, A

“…Commitment of Th lymphocytes to the Th1 phenotype, as characterized by the expression of the major proinflammatory cytokine IFN-gamma, may be critically…”
Get full text

Expression of ICOS In Vivo Defines CD4 super(+) Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10 by Loehning, M, Hutloff, A, Kallinich, T, Mages, H W, Bonhagen, K, Radbruch, A, Hamelmann, E, Kroczek, R A

“…The studies performed to date analyzed the overall participation of the inducible costimulator (ICOS) in model diseases, but did not yield information on the…”
Get full text

Regulation and Function of T1/ST2 Expression on CD4 super(+) T Cells: Induction of Type 2 Cytokine Production by T1/ST2 Cross-Linking by Meisel, C, Bonhagen, K, Loehning, M, Coyle, A J, Gutierrez-Ramos, J, Radbruch, A, Kamradt, T

“…The orphan receptor T1/ST2, a member of the IL-1R family, is preferentially expressed on the surface of murine Th2 cells. In this study, we analyzed the…”
Get full text

Regulation of Expression of IL-4 Alleles: Analysis Using a Chimeric GFP/IL-4 Gene by Hu-Li, Jane, Pannetier, C, Guo, Liying, Loehning, M, Gu, Hua, Watson, C, Assenmacher, M, Radbruch, A, Paul, W E

“…CD4 cells from mice heterozygous for an IL-4 and a GFP/IL-4 gene frequently express a single allele. Analysis of IL-4 or GFP production by cells from recently…”
Get full text

Reversible expression of tryptases in continuous L138.8A mast cells by Rupp, Brigitte, Löhning, Max, Werenskiold, Anne Katrin

“…It has been established that mast cells can alter their expression of granule chymases and tryptases in vivo. In vitro, a reversible cytokine regulation has so…”
Get full text

T1/ST2 Expression Is Enhanced on CD4 super(+) T Cells from Schistosome Egg-Induced Granulomas: Analysis of Th Cell Cytokine Coexpression Ex Vivo by Loehning, M, Grogan, J L, Coyle, A J, Yazdanbakhsh, M, Meisel, C, Gutierrez-Ramos, J C, Radbruch, A, Kamradt, T

“…Th cells are categorized into subsets based on the cytokine production of in vitro-differentiated Th populations. For in vivo-differentiated Th subsets, little…”
Get full text