Search Results - "Lodge, Daniel J"

Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia by Lodge, Daniel J, Grace, Anthony A

“…Substantial evidence suggests that psychosis in schizophrenia is associated with dysregulation of subcortical dopamine system function. Here we examine…”
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The Medial Prefrontal and Orbitofrontal Cortices Differentially Regulate Dopamine System Function by LODGE, Daniel J

“…The prefrontal cortex (PFC) is essential for top-down control over higher-order executive function. In this study we demonstrate that the medial prefrontal…”
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Aberrant Hippocampal Activity Underlies the Dopamine Dysregulation in an Animal Model of Schizophrenia by Lodge, Daniel J, Grace, Anthony A

“…Evidence supports a dysregulation of subcortical dopamine (DA) system function as a common etiology of psychosis; however, the factors responsible for this…”
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Aversive stimuli alter ventral tegmental area dopamine neuron activity via a common action in the ventral hippocampus by Valenti, Ornella, Lodge, Daniel J, Grace, Anthony A

“…Stress is a physiological, adaptive response to changes in the environment, but can also lead to pathological alterations, such as relapse in psychiatric…”
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Gestational methylazoxymethanol acetate administration: A developmental disruption model of schizophrenia by Lodge, Daniel J., Grace, Anthony A.

“…Animal models are critical for the study of psychiatric disorders since they allow the use of invasive methods that cannot be used for ethical reasons in…”
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Discrete hippocampal projections are differentially regulated by parvalbumin and somatostatin interneurons by Lodge, Daniel J., Elam, Hannah B., Boley, Angela M., Donegan, Jennifer J.

“…People with schizophrenia show hyperactivity in the ventral hippocampus (vHipp) and we have previously demonstrated distinct behavioral roles for vHipp cell…”
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Regulation of firing of dopaminergic neurons and control of goal-directed behaviors by Grace, Anthony A, Floresco, Stan B, Goto, Yukiori, Lodge, Daniel J

“…There are several brain regions that have been implicated in the control of motivated behavior and whose disruption leads to the pathophysiology observed in…”
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Aberrant Dopamine System Function in the Ferrous Amyloid Buthionine (FAB) Rat Model of Alzheimer's Disease by Perez, Stephanie M, Boley, Angela M, McCoy, Alexandra M, Lodge, Daniel J

“…Antipsychotics increase the risk of death in elderly patients with Alzheimer's disease (AD). Thus, there is an immediate need for novel therapies to treat…”
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α5-GABAA Receptor Modulation Reverses Behavioral and Neurophysiological Correlates of Psychosis in Rats with Ventral Hippocampal Alzheimer's Disease-like Pathology by Eassa, Nicole E, Perez, Stephanie M, Boley, Angela M, Elam, Hannah B, Sharmin, Dishary, Cook, James M, Lodge, Daniel J

“…Of the 35 million people in the world suffering from Alzheimer's Disease (AD), up to half experience comorbid psychosis. Antipsychotics, used to treat…”
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Investigation of a Ventrodorsal Hippocampal Pathway to Regulate Cognition by Lodge, Daniel J.

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The Hippocampus Modulates Dopamine Neuron Responsivity by Regulating the Intensity of Phasic Neuron Activation by LODGE, Daniel J, GRACE, Anthony A

“…Aberrant dopamine (DA) signaling has been advanced as a contributing factor to the pathophysiology of a number of psychiatric conditions including…”
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Developmental pathology, dopamine, stress and schizophrenia by Lodge, Daniel J., Grace, Anthony A.

“…▶ Ventral hippocampal (vHipp) activity sets the gain of the dopamine signal. ▶ Stress, drug abuse, genetic and environmental factors interact to alter vHipp…”
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Orexin receptor antagonists reverse aberrant dopamine neuron activity and related behaviors in a rodent model of stress-induced psychosis by Elam, Hannah B., Perez, Stephanie M., Donegan, Jennifer J., Lodge, Daniel J.

“…Post-traumatic stress disorder (PTSD) is a prevalent condition affecting approximately 8% of the United States population and 20% of United States combat…”
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GL-II-73, a Positive Allosteric Modulator of α5GABAA Receptors, Reverses Dopamine System Dysfunction Associated with Pilocarpine-Induced Temporal Lobe Epilepsy by McCoy, Alexandra M., Prevot, Thomas D., Sharmin, Dishary, Cook, James M., Sibille, Etienne L., Lodge, Daniel J.

“…Although seizures are a hallmark feature of temporal lobe epilepsy (TLE), psychiatric comorbidities, including psychosis, are frequently associated with TLE…”
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Developmental alterations in the transcriptome of three distinct rodent models of schizophrenia by Donegan, Jennifer J, Boley, Angela M, Glenn, Jeremy P, Carless, Melanie A, Lodge, Daniel J

“…Schizophrenia is a debilitating disorder affecting just under 1% of the population. While the symptoms of this disorder do not appear until late adolescence,…”
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The MAM rodent model of schizophrenia by Lodge, Daniel J

“…Rodent models of human disease are essential to obtain a better understanding of disease pathology, the mechanism of action underlying conventional treatments,…”
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Comparative analysis of MBD-seq and MeDIP-seq and estimation of gene expression changes in a rodent model of schizophrenia by Neary, Jennifer L., Perez, Stephanie M., Peterson, Kara, Lodge, Daniel J., Carless, Melanie A.

“…We conducted a comparative study of multiplexed affinity enrichment sequence methodologies (MBD-seq and MeDIP-seq) in a rodent model of schizophrenia, induced…”
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Wikipedia: a key tool for global public health promotion by Heilman, James M, Kemmann, Eckhard, Bonert, Michael, Chatterjee, Anwesh, Ragar, Brent, Beards, Graham M, Iberri, David J, Harvey, Matthew, Thomas, Brendan, Stomp, Wouter, Martone, Michael F, Lodge, Daniel J, Vondracek, Andrea, de Wolff, Jacob F, Liber, Casimir, Grover, Samir C, Vickers, Tim J, Meskó, Bertalan, Laurent, Michaël R

“…The Internet has become an important health information resource for patients and the general public. Wikipedia, a collaboratively written Web-based…”
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An augmented dopamine system function is present prior to puberty in the methylazoxymethanol acetate rodent model of schizophrenia by Chen, Li, Perez, Stephanie M., Lodge, Daniel J.

“…ABSTRACT Schizophrenia is a disease typically associated with an adolescent onset. Although there have been a considerable number of imaging studies…”
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Buprenorphine Exposure Alters the Development and Migration of Interneurons in the Cortex by Nieto-Estévez, Vanesa, Donegan, Jennifer J, McMahon, Courtney L, Elam, Hannah B, Chavera, Teresa A, Varma, Parul, Berg, Kelly A, Lodge, Daniel J, Hsieh, Jenny

“…The misuse of opioids has reached epidemic proportions over the last decade, with over 2.1 million people in the United States suffering from substance use…”
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