Search Results - "Lockwood, Karina"

A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry by Chen, Yanwen, Lear, Travis B., Evankovich, John W., Larsen, Mads B., Lin, Bo, Alfaras, Irene, Kennerdell, Jason R., Salminen, Laura, Camarco, Daniel P., Lockwood, Karina C., Tuncer, Ferhan, Liu, Jie, Myerburg, Michael M., McDyer, John F., Liu, Yuan, Finkel, Toren, Chen, Bill B.

“…SARS-CoV-2 (2019-nCoV) is the pathogenic coronavirus responsible for the global pandemic of COVID-19 disease. The Spike (S) protein of SARS-CoV-2 attaches to…”
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The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing by Lear, Travis B., Lockwood, Karina C., Ouyang, Yurong, Evankovich, John W., Larsen, Mads B., Lin, Bo, Liu, Yuan, Chen, Bill B.

“…Nutrient sensing is a critical cellular process controlling metabolism and signaling. mTOR complex 1 (mTORC1) is the primary signaling hub for nutrient sensing…”
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E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro by Lear, Travis B., Boudreau, Áine N., Lockwood, Karina C., Chu, Elise, Camarco, Daniel P., Cao, Qing, Nguyen, Matthew, Evankovich, John W., Finkel, Toren, Liu, Yuan, Chen, Bill B.

“…The main protease of severe acute respiratory syndrome coronavirus 2, Mpro, is a key viral protein essential for viral infection and replication. Mpro has been…”
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KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation by Lockwood, Karina C., Lear, Travis B., Rajbhandari, Shristi, McKelvey, Alison C., Dunn, Sarah R., Boudreau, Áine N., Liu, Yuan, Chen, Bill B.

“…Dysregulated cytokine signalling is a hallmark of inflammatory bowel diseases. Inflammatory responses of the colon are regulated by the suppressor of cytokine…”
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Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis by Lear, Travis B., Lockwood, Karina C., Larsen, Mads, Tuncer, Ferhan, Kennerdell, Jason R., Morse, Christina, Valenzi, Eleanor, Tabib, Tracy, Jurczak, Michael J., Kass, Daniel J., Evankovich, John W., Finkel, Toren, Lafyatis, Robert, Liu, Yuan, Chen, Bill B.

“…Systemic scleroderma (SSc) is an autoimmune disease that affects over 2.5 million people globally. SSc results in dysfunctional connective tissues with…”
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Modulation of lysosomal function as a therapeutic approach for coronaviral infections by Lear, Travis, Larsen, Mads, Lin, Bo, Cao, Qing, Alfaras, Irene, Kennerdell, Jason, Salminen, Laura, Camarco, Daniel, Lockwood, Karina C., Boudreau, Áine, Ma, Jing, Liu, Jie, Tan, Jay X., Myerburg, Michael M., Chen, Yanwen, St Croix, Claudette, Sekine, Yusuke, Evankovich, John, Finkel, Toren, Chen, Bill B., Liu, Yuan

“…The endo‐lysosomal pathway plays an important role in pathogen clearance and both bacteria and viruses have evolved complex mechanisms to evade this host…”
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A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells by Villandre, John, White, Virginia, Lear, Travis B, Chen, Yanwen, Tuncer, Ferhan, Vaiz, Emily, Tuncer, Beyza, Lockwood, Karina, Camarco, Dan, Liu, Yuan, Chen, Bill B, Evankovich, John

“…Aquaporin 5 (AQP5) is expressed in several cell types in the lung and regulates water transport, which contributes to barrier function during injury and the…”
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The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity by Tong, Yao, Lear, Travis B, Evankovich, John, Chen, Yanwen, Londino, James D, Myerburg, Michael M, Zhang, Yingze, Popescu, Iulia D, McDyer, John F, McVerry, Bryan J, Lockwood, Karina C, Jurczak, Michael J, Liu, Yuan, Chen, Bill B

“…Interleukin-3 (IL-3) receptor α (IL-3Rα) is the α subunit of the ligand-specific IL-3R and initiates intracellular signaling in response to IL-3. IL-3…”
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KIAA0317 regulates pulmonary inflammation through SOCS2 degradation by Lear, Travis B, McKelvey, Alison C, Evankovich, John W, Rajbhandari, Shristi, Coon, Tiffany A, Dunn, Sarah R, Londino, James D, McVerry, Bryan J, Zhang, Yingze, Valenzi, Eleanor, Burton, Christine L, Gordon, Rachael, Gingras, Sebastien, Lockwood, Karina C, Jurczak, Michael J, Lafyatis, Robert, Shlomchik, Mark J, Liu, Yuan, Chen, Bill B

“…Dysregulated proinflammatory cytokine release has been implicated in the pathogenesis of several life-threatening acute lung illnesses such as pneumonia,…”
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Nitro-oleic acid attenuates pro-inflammatory metabolic signaling in LPS activated macrophages by Uvalle, Crystal, Gelhaus, Stacy, Fong, Erica, Mullett, Steve, Lockwood, Karina, Suber, Tomeka

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Abstract 2101: Modulating Alzheimer's Disease by mTORC1 inhibition to augment lysosomal activity by Lear, Travis, Lockwood, Karina, Boudreau, Áine, Larsen, Mads, Lin, Bo, Sukoff-Rizzo, Stacey, Liu, Yuan, Finkel, Toren, Chen, Bill

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Uncovering the Regulation of Fibrotic Signaling in Scleroderma by the Ubiquitin E3 Ligase KLHL42 by Lear, Travis, Lockwood, Karina C., Tuncer, Ferhan, Larsen, Mads, Evankovich, John, Lafyatis, Robert, Liu, Yuan, Chen, Bill B.

“…Abstract only…”
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A high throughput screen for TMPRSS2 expression identifies FDA‐approved and clinically advanced compounds that can limit SARS‐CoV‐2 entry by Lear, Travis, Chen, Yanwen, Evankovich, John, Larsen, Mads, Lin, Bo, Alfaras, Irene, Kennerdell, Jason, Salminen, Laura, Camarco, Daniel, Lockwood, Karina, Tuncer, Ferhan, Liu, Jie, Myerburg, Michael, McDyer, John, Liu, Yuan, Finkel, Toren, Chen, Bill

“…SARS‐CoV‐2 (2019‐nCoV) is the pathogenic coronavirus responsible for the global pandemic of COVID‐19 disease. The Spike (S) protein of SARS‐CoV‐2 attaches to…”
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STAT1 Employs Myeloid Cell-Extrinsic Mechanisms to Regulate the Neutrophil Response and Provide Protection against Invasive Klebsiella pneumoniae Lung Infection by Gonzalez-Ferrer, Shekina, Peñaloza, Hernán F, van der Geest, Rick, Xiong, Zeyu, Gheware, Atish, Tabary, Mohammadreza, Kochin, Megan, Dalton, Kathryn, Zou, Henry, Lou, Dequan, Lockwood, Karina, Zhang, Yingze, Bain, William G, Mallampalli, Rama K, Ray, Anuradha, Ray, Prabir, Van Tyne, Daria, Chen, Kong, Lee, Janet S

“…Klebsiella pneumoniae (KP) is an extracellular Gram-negative bacterium that causes infections in the lower respiratory and urinary tracts and the bloodstream…”
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Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis by Lear, Travis B, Lockwood, Karina C, Larsen, Mads, Tuncer, Ferhan, Kennerdell, Jason R, Morse, Christina, Valenzi, Eleanor, Tabib, Tracy, Jurczak, Michael J, Kass, Daniel J, Evankovich, John W, Finkel, Toren, Lafyatis, Robert, Liu, Yuan, Chen, Bill B

“…Systemic scleroderma (SSc) is an autoimmune disease that affects over 2.5 million people globally. SSc results in dysfunctional connective tissues with…”
Get full text