Search Results - "Lockwood, Graham F"

Dose-Escalating and Pharmacological Study of Oxaliplatin in Adult Cancer Patients With Impaired Renal Function: A National Cancer Institute Organ Dysfunction Working Group Study by TAKIMOTO, Chris H, REMICK, Scot C, IVY, Percy, EGORIN, Merrill, SCHULER, Barbara, GREENSLADE, Denis, GOETZ, Andrew, KNIGHT, Ronald, THOMAS, Rebecca, MONAHAN, Brian P, DAHUT, William, GREM, Jean L, SHARMA, Sunil, MANI, Sridhar, RAMANATHAN, Ramesh K, DOROSHOW, James, HAMILTON, Anne, MULKERIN, Daniel, GRAHAM, Martin, LOCKWOOD, Graham F

“…This study was undertaken to determine the toxicities, pharmacokinetics, and maximum tolerated doses of oxaliplatin in patients with renal impairment and to…”
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Clinical Pharmacokinetics of Oxaliplatin: A Critical Review by GRAHAM, M. A, LOCKWOOD, G. F, GREENSLADE, D, BRIENZA, S, BAYSSAS, M, GAMELIN, E

“…Oxaliplatin ( cis -[(1 R ,2 R )-1,2-cyclohexanediamine- N,N ′] oxalato(2-)- O,O ′] platinum; Eloxatine) is a novel platinum coordination complex used for the…”
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Administration of oxaliplatin to patients with renal dysfunction: a preliminary report of the national cancer institute organ dysfunction working group by Takimoto, Chris H, Remick, Scot C, Sharma, Sunil, Mani, Sridhar, Ramanathan, Ramesh K, Doroshow, James H, Hamilton, Anne, Mulkerin, Daniel, Graham, Martin, Lockwood, Graham F, Ivy, Percy, Egorin, Merrill, Greenslade, Denis, Goetz, Andrew, Grem, Jean L

“…Oxaliplatin is an approved agent with clinical activity in the treatment of advanced colorectal cancer. Preliminary pharmacokinetic evidence suggests that…”
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In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration by LIN, Yvonne S, LOCKWOOD, Graham F, THUMMEL, Kenneth E, GRAHAM, Martin A, BRIAN, William R, LOI, Cho-Ming, DOBRINSKA, Michael R, SHEN, Danny D, WATKINS, Paul B, WILKINSON, Grant R, KHARASCH, Evan D

“…We investigated whether a single plasma midazolam concentration could serve as an accurate predictor of total midazolam clearance, an established in-vivo probe…”
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Phase I Pharmacokinetic Study of the Novel Antitumor Agent SR233377 by LORUSSO, P. M, FOSTER, B. J, LOCKWOOD, G. F, CORBETT, T. H, WOZNIAK, A, HEILBRUN, L. K, MCCORMICK, J. I, RUBLE, P. E, GRAHAM, M. A, PURVIS, J, RAKE, J, DROZD, M

“…SR233377 is a novel thioxanthenone analogue that demonstrated solid tumor selectivity in vitro with activity confirmed in vivo against several murine tumors…”
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Determination of myocardial and serum digoxin concentrations in children by specific and nonspecific assay methods by Wagner, J G, Dick, 2nd, M, Behrendt, D M, Lockwood, G F, Sakmar, E, Hees, P

“…After obtaining samples at open heart surgery, serum and right atrial digoxin concentrations were measured in 25 children by a nonspecific, direct…”
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Administration of oxaliplatin to patients with renal dysfunction: A preliminary report of the National Cancer Institute Organ Dysfunction Working Group: Perspectives on oxaliplatin in the treatment of gastrointestinal cancers by TAKIMOTO, Chris H, REMICK, Scot C, IVY, Percy, EGORIN, Merrill, GREENSLADE, Denis, GOETZ, Andrew, GREM, Jean L, SHARMA, Sunil, MANI, Sridhar, RAMANATHAN, Ramesh K, DOROSHOW, James H, HAMILTON, Anne, MULKERIN, Daniel, GRAHAM, Martin, LOCKWOOD, Graham F

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High-performance liquid chromatographic determination of ibuprofen and its major metabolites in biological fluids by Lockwood, G F, Wagner, J G

“…A sensitive and selective high-performance liquid-chromatographic assay for ibuprofen and its major metabolites in biological fluids is described. To ensure…”
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The Effects of Stress on Drug Disposition in vivo by Lockwood, Graham F

“…The effects of three stresses on the metabolism of a highly and lowly cleared model compound have been considered. The drugs chosen were diazepam and…”
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In vitro drug metabolism and pharmacokinetics of diazepam in cynomolgus monkey hepatocytes during culture for six days by Seddon, T, Lockwood, G F, Chenery, R J

“…Diazepam (DZ), N-desmethyl diazepam (NOR) and temazepam (TEM) were used as substrates in drug metabolism studies to characterize the changes in cytochrome…”
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Accumulation and time to steady state for drugs subject to enterohepatic cycling: a stimulation study by Shepard, T A, Gannaway, D J, Lockwood, G F

“…A physiologically realistic model was used to investigate through simulation the multiple-dose behavior of drugs subject to enterohepatic cycling. The model…”
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Pharmacokinetics of ibuprofen in man--III: Plasma protein binding by Lockwood, G F, Albert, K S, Szpunar, G J, Wagner, J G

“…Plasma protein binding of ibuprofen was measured by equilibrium dialysis on 406 plasma samples collected from 15 normal volunteers following doses of 400, 800,…”
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Pharmacokinetics of ibuprofen in man IV: absorption and disposition by Wagner, J G, Albert, K S, Szpunar, G J, Lockwood, G F

“…Fifteen normal male volunteers received 400, 800, and 1200 mg doses of ibuprofen as 1, 2, or 3 tablets, respectively, in crossover fashion, then 420 mg in…”
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Mean residence time for drugs subject to enterohepatic cycling by Shepard, T A, Lockwood, G F, Aarons, L J, Abrahams, I D

“…A physiologically realistic model of enterohepatic cycling (EHC) which includes separate liver and gallbladder compartments, discontinuous gallbladder emptying…”
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The antipyrine breath test in the rat: a pharmacokinetic model by LOCKWOOD, G. F, CHENERY, R. J, OLDHAM, H. G, STANDRING, P, NORMAN, S. J

“…Breath tests have been widely advocated for use as non-invasive probes of mixed function oxidase activity in vivo. A catenary sequence of events begins with…”
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