Search Results - "Lockwood, Christina M."

Pan-Trk Immunohistochemistry Identifies NTRK Rearrangements in Pediatric Mesenchymal Tumors by Rudzinski, Erin R, Lockwood, Christina M, Stohr, Bradley A, Vargas, Sara O, Sheridan, Rachel, Black, Jennifer O, Rajaram, Veena, Laetsch, Theodore W, Davis, Jessica L

“…Activating neurotrophic receptor kinase (NTRK) fusions define certain pediatric mesenchymal tumors, including infantile fibrosarcoma and cellular mesoblastic…”
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Expanding the Spectrum of Pediatric NTRK-rearranged Mesenchymal Tumors by Davis, Jessica L, Lockwood, Christina M, Stohr, Bradley, Boecking, Carolin, Al-Ibraheemi, Alyaa, DuBois, Steven G, Vargas, Sara O, Black, Jennifer O, Cox, Michael C, Luquette, Mark, Turpin, Brian, Szabo, Sara, Laetsch, Theodore W, Albert, Catherine M, Parham, David M, Hawkins, Douglas S, Rudzinski, Erin R

“…Pediatric mesenchymal tumors harboring variant NTRK fusions (ETV6-negative) are being increasingly described; however, the histologic and clinical features of…”
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Variability in, variability out: best practice recommendations to standardize pre-analytical variables in the detection of circulating and tissue microRNAs by Khan, Jenna, Lieberman, Joshua A, Lockwood, Christina M

“…microRNAs (miRNAs) hold promise as biomarkers for a variety of disease processes and for determining cell differentiation. These short RNA species are robust,…”
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Infantile NTRK-associated Mesenchymal Tumors by Davis, Jessica L, Lockwood, Christina M, Albert, Catherine M, Tsuchiya, Karen, Hawkins, Douglas S, Rudzinski, Erin R

“…Pediatric fibroblastic/myofibroblastic lesions are a relatively common group of tumors with varying morphologies, for which the molecular mechanisms are…”
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T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides by Sufficool, Kari E., MD, Lockwood, Christina M., PhD, Abel, Haley J., PhD, Hagemann, Ian S., MD, PhD, Schumacher, Jonathan A., MS, Kelley, Todd W., MD, Duncavage, Eric J., MD

“…Background T-cell receptor (TCR) clonality assessment is a principal diagnostic test in the management of mycosis fungoides (MF). However, current polymerase…”
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Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones by Sarthy, Jay F, Meers, Michael P, Janssens, Derek H, Henikoff, Jorja G, Feldman, Heather, Paddison, Patrick J, Lockwood, Christina M, Vitanza, Nicholas A, Olson, James M, Ahmad, Kami, Henikoff, Steven

“…Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone…”
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Beyond the Blood: CSF-Derived cfDNA for Diagnosis and Characterization of CNS Tumors by McEwen, Abbye E, Leary, Sarah E S, Lockwood, Christina M

“…Genetic data are rapidly becoming part of tumor classification and are integral to prognosis and predicting response to therapy. Current molecular tumor…”
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Genomic surveillance of SARS-CoV-2 Omicron variants on a university campus by Weil, Ana A., Luiten, Kyle G., Casto, Amanda M., Bennett, Julia C., O’Hanlon, Jessica, Han, Peter D., Gamboa, Luis S., McDermot, Evan, Truong, Melissa, Gottlieb, Geoffrey S., Acker, Zack, Wolf, Caitlin R., Magedson, Ariana, Chow, Eric J., Lo, Natalie K., Pothan, Lincoln C., McDonald, Devon, Wright, Tessa C., McCaffrey, Kathryn M., Figgins, Marlin D., Englund, Janet A., Boeckh, Michael, Lockwood, Christina M., Nickerson, Deborah A., Shendure, Jay, Bedford, Trevor, Hughes, James P., Starita, Lea M., Chu, Helen Y.

“…Novel variants continue to emerge in the SARS-CoV-2 pandemic. University testing programs may provide timely epidemiologic and genomic surveillance data to…”
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At Preeclampsia Diagnosis, Total Cell‐Free DNA Concentration is Elevated and Correlates With Disease Severity by Kolarova, Teodora R., Gammill, Hilary S., Nelson, J. Lee, Lockwood, Christina M., Shree, Raj

“…Background Placental derived cell‐free DNA (cfDNA), widely utilized for prenatal screening, may serve as a biomarker for preeclampsia. To determine whether…”
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Detection of FLT3 Internal Tandem Duplication in Targeted, Short-Read-Length, Next-Generation Sequencing Data by Spencer, David H, Abel, Haley J, Lockwood, Christina M, Payton, Jacqueline E, Szankasi, Philippe, Kelley, Todd W, Kulkarni, Shashikant, Pfeifer, John D, Duncavage, Eric J

“…A recurrent somatic mutation frequently found in cytogenetically normal acute myeloid leukemia (AML) is internal tandem duplication (ITD) in the fms-related…”
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Circulating MicroRNA miR-323-3p as a Biomarker of Ectopic Pregnancy by ZHEN ZHAO, QIUHONG ZHAO, WARRICK, Joshua, LOCKWOOD, Christina M, WOODWORTH, Alison, MOLEY, Kelle H, GRONOWSKI, Ann M

“…The use of serum human chorionic gonadotropin (hCG) and progesterone to identify patients with ectopic pregnancy (EP) has been shown to have poor clinical…”
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Whole-genome sequencing as an investigational device for return of hereditary disease risk and pharmacogenomic results as part of the All of Us Research Program by Venner, Eric, Muzny, Donna, Smith, Joshua D, Walker, Kimberly, Neben, Cynthia L, Lockwood, Christina M, Empey, Phillip E, Metcalf, Ginger A, Kachulis, Chris, Mian, Sana, Musick, Anjene, Rehm, Heidi L, Harrison, Steven, Gabriel, Stacey, Gibbs, Richard A, Nickerson, Deborah, Zhou, Alicia Y, Doheny, Kimberly, Ozenberger, Bradley, Topper, Scott E, Lennon, Niall J

“…The All of Us Research Program (AoURP, "the program") is an initiative, sponsored by the National Institutes of Health (NIH), that aims to enroll one million…”
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Microsatellite instability in prostate cancer by PCR or next-generation sequencing by Hempelmann, Jennifer A, Lockwood, Christina M, Konnick, Eric Q, Schweizer, Michael T, Antonarakis, Emmanuel S, Lotan, Tamara L, Montgomery, Bruce, Nelson, Peter S, Klemfuss, Nola, Salipante, Stephen J, Pritchard, Colin C

“…Microsatellite instability (MSI) is now being used as a sole biomarker to guide immunotherapy treatment for men with advanced prostate cancer. Yet current…”
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Mutations of the DNA repair gene PNKP in a patient with microcephaly, seizures, and developmental delay (MCSZ) presenting with a high-grade brain tumor by Jiang, Bingcheng, Murray, Cameron, Cole, Bonnie L., Glover, J. N. Mark, Chan, Gordon K., Deschenes, Jean, Mani, Rajam S., Subedi, Sudip, Nerva, John D., Wang, Anthony C., Lockwood, Christina M., Mefford, Heather C., Leary, Sarah E. S., Ojemann, Jeffery G., Weinfeld, Michael, Ene, Chibawanye I.

“…Polynucleotide Kinase-Phosphatase (PNKP) is a bifunctional enzyme that possesses both DNA 3′-phosphatase and DNA 5′-kinase activities, which are required for…”
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Looking beyond year 1 in the molecular era of pediatric brain tumor diagnosis: confirmatory testing of germline variants found on tumor sequencing by Greene, Brittany L, Stasi, Shannon M, Ting, Michelle A, Waligorski, Natalie, Cole, Bonnie L, Lockwood, Christina M, Paulson, Vera A, Buchan, Jillian G, Lee, Amy, Ojemann, Jeffrey G, Ellenbogen, Richard G, Stevens, Jeffrey, Leary, Sarah E S

“…Somatic molecular profiling of pediatric brain tumors aids with the diagnosis and treatment of patients with a variety of high- and low-grade central nervous…”
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Validation and implementation of a modular targeted capture assay for the detection of clinically significant molecular oncology alterations by Kuo, Ayako J., Paulson, Vera A., Hempelmann, Jennifer A., Beightol, Mallory, Todhunter, Sheena, Colbert, Brice G., Salipante, Stephen J., Konnick, Eric Q., Pritchard, Colin C., Lockwood, Christina M.

“…The rapid discovery of clinically significant genetic variants has translated to next-generation sequencing assays becoming out-of-date by the time they are…”
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Detection of Gene Rearrangements in Targeted Clinical Next-Generation Sequencing by Abel, Haley J, Al-Kateb, Hussam, Cottrell, Catherine E, Bredemeyer, Andrew J, Pritchard, Colin C, Grossmann, Allie H, Wallander, Michelle L, Pfeifer, John D, Lockwood, Christina M, Duncavage, Eric J

“…The identification of recurrent gene rearrangements in the clinical laboratory is the cornerstone for risk stratification and treatment decisions in many…”
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Clarification of Information in "Navigating Next-Generation Sequencing Laboratory Developed Tests: A Critical Look at Proficiency Testing, US Food and Drug Administration Regulations, and Clinical Laboratory Performance Tests" by Lockwood, Christina M

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The “SEED” Study: The Feasibility of Selecting Patient-Specific Biologically Targeted Therapy with Sorafenib, Everolimus, Erlotinib or Dasatinib for Pediatric and Young Adult Patients with Recurrent or Refractory Brain Tumors by Cole, Bonnie L., Starr, Kimberly, Lockwood, Christina M., Leary, Sarah E. S.

“…BACKGROUNDPediatric brain tumors are the leading cause of cancer death in children and represent a variety of diseases and molecular subtypes. This study…”
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Recurrent EGFR alterations in NTRK3 fusion negative congenital mesoblastic nephroma by Lei, Li, Stohr, Bradley A., Berry, Stacey, Lockwood, Christina M., Davis, Jessica L., Rudzinski, Erin R., Kunder, Christian A.

“…To identify oncogenic driver mutations in congenital mesoblastic nephroma (CMN) cases lacking ETV6-NTRK3 fusion and discuss their diagnostic value. The…”
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