Search Results - "Lockridge, O"

Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine by Mesulam, M.-M, Guillozet, A, Shaw, P, Levey, A, Duysen, E.G, Lockridge, O

“…Acetylcholinesterase is one of the most prominent constituents of central cholinergic pathways. It terminates the synaptic action of acetylcholine through…”
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Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon by Duysen, E G, Parikh, K, Aleti, V, Manne, V, Lockridge, O, Chilukuri, N

“…Human paraoxonase1 (hPON1) is a potential therapeutic against the toxicity of organophosphorus (OP) pesticides and chemical warfare nerve agents. We tested…”
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Pesticides and susceptible populations: people with butyrylcholinesterase genetic variants may be at risk by Lockridge, O, Masson, P

“…Butyrylcholinesterase (BChE) scavenges low doses of organophosphorus (for example, paraoxon) and carbamate pesticides (for example, carbaryl) and in this way…”
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Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins by Varfolomeev, S. D., Lushchekina, S. V., Nemukhin, A. V., Kulakova, A. M., Kots, E. D., Makhaeva, G. F., Delacour, H., Lockridge, O., Masson, P.

“…The nature of individual sensitivity to drugs associated with molecular polymorphism of human enzymes is discussed. The influence of molecular polymorphism on…”
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Comparison of butyrylcholinesterase and acetylcholinesterase by Chatonnet, A, Lockridge, O

“…In vertebrates two different enzymes hydrolyse acetylcholine. Acetylcholinesterase (EC 3.1.1.7; AChE) terminates the action of acetylcholine at the…”
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Comparison of cognitive functions between people with silent and wild-type butyrylcholinesterase by Manoharan, I, Kuznetsova, A, Fisk, J D, Boopathy, R, Lockridge, O, Darvesh, S

“…In the human brain, butyrylcholinesterase (BuChE) is expressed in neurons and glia. For example, many nuclei in the human thalamus, with projections to the…”
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Reconsideration of the Catalytic Center and Mechanism of Mammalian Paraoxonase/Arylesterase by Sorenson, Robert C., Primo-Parmo, Sergio L., Kuo, Chung-Liang, Adkins, Steve, Lockridge, Oksana, La Du, Bert N.

“…For three decades, mammalian paraoxonase (A-esterase, aromatic esterase, arylesterase; PON, EC 3.1.8.1) has been thought to be a cysteine esterase…”
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The active site of human paraoxonase (PON1) by Josse, Denis, Lockridge, Oksana, Xie, Weihua, Bartels, Cynthia F., Schopfer, Lawrence M., Masson, Patrick

“…Ideally we would like to treat people exposed to nerve agents with an enzyme that rapidly destroys nerve agents. The enzymes considered for such a role include…”
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(33) Structural data on the aging of diethylphosphoryl-butyrylcholinesterase by Nachon, F., Asojo, O.A., Borgstahl, G., Masson, P., Lockridge, O.

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The cloning and expression of a gene encoding Old Yellow Enzyme from Saccharomyces carlsbergensis by Saito, K., Thiele, D.J., Davio, M., Lockridge, O., Massey, V.

“…We have identified a gene that encodes Old Yellow Enzyme in brewer's bottom yeast. The open reading frame encodes a polypeptide of 400 amino acids with Mr =…”
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Protein folding and assembly in vitro parallel intracellular folding and assembly. Catalysis of folding and assembly of the human chorionic gonadotropin alpha beta dimer by protein disulfide isomerase by Huth, J R, Perini, F, Lockridge, O, Bedows, E, Ruddon, R W

“…Although purified proteins will refold and assemble in vitro, it is not known if cellular factors change the mechanisms of these processes. Based on the gel…”
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DNA mutation associated with the human butyrylcholinesterase K-variant and its linkage to the atypical variant mutation and other polymorphic sites by BARTELS, C. F, JENSEN, F. S, LOCKRIDGE, O, VAN DER SPEK, A. F. L, RUBINSTEIN, H. M, LUBRANO, T, LA DU, B. N

“…Genomic DNA from two families exhibiting the K-variant phenotype of serum butyrylcholinesterase was amplified by PCR and sequenced to determine the molecular…”
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Complete amino acid sequence of human serum cholinesterase by Lockridge, O, Bartels, C F, Vaughan, T A, Wong, C K, Norton, S E, Johnson, L L

“…The complete amino acid sequence of human serum cholinesterase (choline esterase II (unspecific), EC 3.1.1.8) was determined by Edman degradation of purified…”
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Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism by BARTELS, C. F, ZELINSKI, T, LOCKRIDGE, O

“…Acetylcholinesterase is present in innervated tissues, where its function is to terminate nerve impulse transmission. It is also found in the red blood cell…”
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Identification of the Structural Mutation Responsible for the Dibucaine-Resistant (Atypical) Variant Form of Human Serum Cholinesterase by McGuire, Mary C., Nogueira, Christine P., Bartels, Cynthia F., Lightstone, Harold, Hajra, Amitav, Abraham F. L. Van Der Spek, Lockridge, Oksana, La Du, Bert N.

“…A point mutation in the gene for human serum cholinesterase was identified that changes Asp-70 to Gly in the atypical form of serum cholinesterase. The…”
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Recombinant human butyrylcholinesterase G390V, the fluoride-2 variant, expressed in Chinese hamster ovary cells, is a low affinity variant by Masson, P, Adkins, S, Gouet, P, Lockridge, O

“…Kinetics of recombinant fluoride-2 variant of human butyrylcholinesterase (Gly390 Val) secreted by Chinese hamster ovary cells were compared to recombinant…”
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Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma by Li, Bin, Sedlacek, Meghan, Manoharan, Indumathi, Boopathy, Rathnam, Duysen, Ellen G., Masson, Patrick, Lockridge, Oksana

“…The goal of this work was to identify the esterases in human plasma and to clarify common misconceptions. The method for identifying esterases was…”
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Naturally occurring mutation, Asp70his, in human butyrylcholinesterase by Boeck, Andreea Ticu, Fry, Debra L, Sastre, Antonio, Lockridge, Oksana

“…People with genetic variants of butyrylcholinesterase can have hours of prolonged apnoea after a normal dose of succinylcholine or mivacurium. Serum samples…”
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Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA by Jbilo, O, Bartels, C F, Chatonnet, A, Toutant, J P, Lockridge, O

“…Cholinesterase inhibitors occur naturally in the calabar bean (eserine), green potatoes (solanine), insect-resistant crab apples, the coca plant (cocaine) and…”
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Knockout of one acetylcholinesterase allele in the mouse by Xie, Weihua, Wilder, Phillip J, Stribley, Judith, Chatonnet, Arnaud, Rizzino, Angie, Taylor, Palmer, Hinrichs, Steven H, Lockridge, Oksana

“…One allele of the AChE gene (ACHE) was knocked out in embryonic stem (ES) cells by homologous recombination. The targeting vector contained 2 kb of a TK gene…”
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