Search Results - "Lockowandt, Marcus"
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A comparison of AAV-vector production methods for gene therapy and preclinical assessment
Published in Scientific reports (09-12-2020)“…Adeno Associated Virus (AAV)-mediated gene expression in the brain is widely applied in the preclinical setting to investigate the therapeutic potential of…”
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Journal Article -
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GDNF-mediated rescue of the nigrostriatal system depends on the degree of degeneration
Published in Gene therapy (01-02-2019)“…Glial cell-line derived neurotrophic factor (GDNF) is a promising therapeutic molecule to treat Parkinson’s disease. Despite an excellent profile in…”
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Journal Article -
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Optimization of production and transgene expression of a retrogradely transported pseudotyped lentiviral vector
Published in Journal of neuroscience methods (15-04-2020)“…•Use of polyethylenimine for 293 T transfection improves consistency of viral titers.•The hSyn promoter is more effective in medium spiny neurons compared to…”
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Journal Article