Search Results - "Lockhart, Nicole"

The evolution of biobanking best practices by Vaught, Jim, Lockhart, Nicole C.

“…Biobanks and biospecimens are critical components for many areas of clinical and basic research. The quality of biospecimens and associated data must be…”
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A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project by Carithers, Latarsha J, Ardlie, Kristin, Barcus, Mary, Branton, Philip A, Britton, Angela, Buia, Stephen A, Compton, Carolyn C, DeLuca, David S, Peter-Demchok, Joanne, Gelfand, Ellen T, Guan, Ping, Korzeniewski, Greg E, Lockhart, Nicole C, Rabiner, Chana A, Rao, Abhi K, Robinson, Karna L, Roche, Nancy V, Sawyer, Sherilyn J, Segrè, Ayellet V, Shive, Charles E, Smith, Anna M, Sobin, Leslie H, Undale, Anita H, Valentino, Kimberly M, Vaught, Jim, Young, Taylor R, Moore, Helen M

“…The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and…”
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Providing Individual Research Results to Participants by Kaufman, David J, Lockhart, Nicole C, Brody, Lawrence C

“…Kaufman et al comment on the study by Wong et al discussing the issues that may arise when participants in biomedical research are provided with their…”
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The Ethical, Legal, and Social Implications Program of the National Human Genome Research Institute: Reflections on an Ongoing Experiment by McEwen, Jean E, Boyer, Joy T, Sun, Kathie Y, Rothenberg, Karen H, Lockhart, Nicole C, Guyer, Mark S

“…For more than 20 years, the Ethical, Legal, and Social Implications (ELSI) Program of the National Human Genome Research Institute has supported empirical and…”
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Neutrophil accumulation following passive stretches contributes to adaptations that reduce contraction-induced skeletal muscle injury in mice by Lockhart, Nicole C, Brooks, Susan V

“…Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan Submitted 7 August 2007 ; accepted in final form 13 February…”
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Development of a consensus approach for return of pathology incidental findings in the Genotype-Tissue Expression (GTEx) project by Lockhart, Nicole C, Weil, Carol J, Carithers, Latarsha J, Koester, Susan E, Little, A Roger, Volpi, Simona, Moore, Helen M, Berkman, Benjamin E

“…The active debate about the return of incidental or secondary findings in research has primarily focused on return to research participants, or in some cases,…”
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Custodianship as an ethical framework for biospecimen-based research by Yassin, Rihab, Lockhart, Nicole, González del Riego, Mariana, Pitt, Karen, Thomas, Jeffrey W, Weiss, Linda, Compton, Carolyn

“…Human biological specimens (biospecimens) are increasingly important for research that aims to advance human health. Yet, despite significant proliferation in…”
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Creating a global rare disease patient registry linked to a rare diseases biorepository database: Rare Disease-HUB (RD-HUB) by Rubinstein, Yaffa R, Groft, Stephen C, Bartek, Ronald, Brown, Kyle, Christensen, Ronald A, Collier, Elaine, Farber, Amy, Farmer, Jennifer, Ferguson, John H, Forrest, Christopher B, Lockhart, Nicole C, McCurdy, Kate R, Moore, Helen, Pollen, Geraldine B, Richesson, Rachel, Miller, Vanessa Rangel, Hull, Sara, Vaught, Jim

“…Abstract A movement to create a global patient registry for as many as 7,000 rare diseases was launched at a workshop, "Advancing Rare Disease Research: The…”
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NCI think tank concerning the identifiability of biospecimens and “omic” data by Weil, Carol J., Mechanic, Leah E., Green, Tiffany, Kinsinger, Christopher, Lockhart, Nicole C., Nelson, Stefanie A., Rodriguez, Laura L., Buccini, Laura D.

“…On 11 and 12 June 2012, the National Cancer Institute hosted a think tank concerning the identifiability of biospecimens and “omic” data in order to explore…”
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Intersection of biobanking and clinical care: should discrepant diagnoses and pathological findings be returned to research participants? by Lockhart, Nicole C., Yassin, Rihab, Weil, Carol J., Compton, Carolyn C.

“…Diagnostic discrepancies occur when the diagnosis made on a biospecimen during the course of review at a biobank differs from the original clinical diagnosis…”
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Protection From Contraction-Induced Injury Provided to Skeletal Muscles of Young and Old Mice by Passive Stretch Is Not Due to a Decrease in Initial Mechanical Damage by Lockhart, Nicole C., Brooks, Susan V.

“…Contraction-induced injury occurs when muscles are stretched while activated (lengthening contractions). The injury is initiated by mechanical damage followed…”
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Informed consent process for patient participation in rare disease registries linked to biorepositories by Rubinstein, Yaffa R, Groft, Stephen C, Chandros, Sara Hull, Kaneshiro, Julie, Karp, Barbara, Lockhart, Nicole C, Marshall, Patricia A, Moxley, Richard T, Pollen, Geraldine B, Miller, Vanessa Rangel, Schwartz, Jack

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Meeting research needs with postmortem biospecimen donation: summary of recommendations for postmortem recovery of normal human biospecimens for research by Mucci, Neil R, Moore, Helen M, Brigham, Lori E, Goldthwaite, Charles A, Little, A Roger, Lockhart, Nicole C, Scott, Michael P, Struewing, Jeffery P, Vincent, Stephen L, Compton, Carolyn C

“…Normal human tissues, bodily fluids, and other biospecimens of known quality are essential for research to understand the development of cancer and other…”
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Activation of akt as a potential mediator of adaptations that reduce muscle injury by LOCKHART, Nicole C, BAAR, Keith, MAZZEO, Robert S, BROOKS, Susan V

“…Contraction-induced injury occurs when a muscle is stretched while activated (lengthening contraction). Exposure to a bout of lengthening contractions results…”
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Genetic effects on gene expression across human tissues by Battle, Alexis, Brown, Christopher D, Engelhardt, Barbara E, Montgomery, Stephen B

“…Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that…”
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The Genotype-Tissue Expression (GTEx) project by Lonsdale, John, Thomas, Jeffrey, Salvatore, Mike, Phillips, Rebecca, Hasz, Richard, Walters, Gary, Garcia, Fernando, Young, Nancy, Karasik, Ellen, Gillard, Bryan, Ramsey, Kimberley, Magazine, Harold, Syron, John, Fleming, Johnelle, Traino, Heather, Mosavel, Maghboeba, Barker, Laura, Rohrer, Dan, Maxim, Dan, Filkins, Dana, Harbach, Philip, Cortadillo, Eddie, Berghuis, Bree, Turner, Lisa, Hudson, Eric, Robb, James, Branton, Phillip, Korzeniewski, Greg, Shive, Charles, Tabor, David, Groch, Kevin, Nampally, Sreenath, Buia, Steve, Zimmerman, Angela, Smith, Anna, Burges, Robin, Robinson, Karna, Valentino, Kim, Bradbury, Deborah, Diaz-Mayoral, Norma, Kennedy, Mary, Erickson, Kenyon, Ardlie, Kristin, Winckler, Wendy, Getz, Gad, MacArthur, Daniel, Kellis, Manolis, Thomson, Alexander, Gelfand, Ellen, Donovan, Molly, Meng, Yan, Marcus, Yvonne, Basile, Margaret, Zhu, Jun, Tu, Zhidong, Cox, Nancy J, Gamazon, Eric R, Im, Hae Kyung, Konkashbaev, Anuar, Pritchard, Jonathan, Flutre, Timothèe, Wen, Xiaoquan, Dermitzakis, Emmanouil T, Guigo, Roderic, Monlong, Jean, Sammeth, Michael, Koller, Daphne, Battle, Alexis, Mostafavi, Sara, McCarthy, Mark, Rivas, Manual, Rusyn, Ivan, Nobel, Andrew, Wright, Fred, Shabalin, Andrey, Sturcke, Anne, Paschal, Justin, Anderson, James M, Wilder, Elizabeth L, Derr, Leslie K, Green, Eric D, Temple, Gary, Volpi, Simona, Boyer, Joy T, Thomson, Elizabeth J, Guyer, Mark S, Ng, Cathy, Abdallah, Assya, Colantuoni, Deborah, Insel, Thomas R, Koester, Susan E, Little, A Roger, Bender, Patrick K, Lehner, Thomas, Compton, Carolyn C, Vaught, Jimmie B, Sawyer, Sherilyn, Lockhart, Nicole C, Demchok, Joanne, Moore, Helen F

“…Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease…”
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Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases by Yang, Jialiang, Huang, Tao, Petralia, Francesca, Long, Quan, Zhang, Bin, Argmann, Carmen, Zhao, Yong, Mobbs, Charles V., Schadt, Eric E., Zhu, Jun, Tu, Zhidong

“…Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic…”
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Genomic Research with Organs and Tissues Originating from Transplant Donors: Ethical Considerations for the GTEx Project by Lockhart, Nicole C., Smith, Anna M., Carithers, Latarsha J., Weil, Carol J.

“…The Genotype-Tissue Expression (GTEx) project is funded by the US National Institutes of Health Common Fund to study human gene expression and regulation in…”
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Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine by Goddard, Katrina A.B., Bernhardt, Barbara A., Biswas, Sawona, Bowling, Kevin M., Caga-anan, Charlisse F., Chinnaiyan, Arul M., Clayton, Ellen W., East, Kelly, Garraway, Levi A., Garrett, Jeremy R., Gray, Stacy W., Hindorff, Lucia A., Lewis, Michelle Huckaby, Hutter, Carolyn M., Janne, Pasi A., Knoppers, Bartha M., Krantz, Ian D., Manolio, Teri A., Nickerson, Deborah A., Ou, Jeffrey, Parsons, Donald W., Petersen, Gloria M., Plon, Sharon E., Rehm, Heidi L., Robinson, Dan, Salama, Joseph S., Scollon, Sarah, Shirts, Brian, Tabor, Holly K., Tarczy-Hornoch, Peter, Appelbaum, Paul S., Arora, Shubhangi, Brothers, Kyle B., Brown, Brian L., Caga-anan, Charlisse F., Calikoglu, Muge G., Christensen, Kurt D., Cirino, Allison L., Conlin, Laura K., Crosslin, David R., Davis, James V., Dorschner, Michael O., Dugan, Noreen P., Exe, Nicole, Fishler, Kristen, Ghrundmeier, Bob, Gordon, Adam S., Gray, David E., Gray, Stacy W., Gutierrez, Amanda M., Hensman, Naomi, Hiatt, Susan M., Himes, Patricia, Horike-Pyne, Martha J., Hull, Sara, Jensen, Brian C., Joffe, Steve, Kaufman, Dave, Kim, Jerry H., Klein, William, Lambert, Michele P., Leo, Michael C., Lewis, Katie, Lonigro, Bob, Machini, Kalotina, Manolio, Teri A., McCullough, Laurence, McMullen, Carmit, Mooney, Sean D., Moore, Elizabeth G., Muzny, Donna, Ng, David, Nickerson, Deborah A., Oliver, Nelly M., Parsons, Will, Plon, Sharon, Powell, Bradford C., Raesz-Martinez, Robin A., Raskind, Wendy H., Rehm, Heidi L., Reiss, Jacob A., Robertson, Peggy D., Robinson, Dan, Salama, Joseph, Scarano, Maria I., Sholl, Lynette M., Silverman, Elian, Simmons, Shirley, Spinner, Nancy B., Stoffel, Elena, Tilley, Christian R., Trinidad, Susan, Ubel, Peter, Vassy, Jason L., Vries, Raymond D., Weck, Karen, Wolf, Susan M., Wynn, Julia, Yu, Joon-Ho, Zikmund-Fisher, Brian J.

“…Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and…”
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Rethinking the “open future” argument against predictive genetic testing of children by Garrett, Jeremy R., Lantos, John D., Biesecker, Leslie G., Childerhose, Janet E., Chung, Wendy K., Holm, Ingrid A., Koenig, Barbara A., McEwen, Jean E., Wilfond, Benjamin S., Brothers, Kyle

“…Professional consensus has traditionally discouraged predictive genetic testing when no childhood interventions can reduce future morbidity or mortality…”
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