Search Results - "Lockhart, C."

Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression by Silva-Fisher, Jessica M., Dang, Ha X., White, Nicole M., Strand, Matthew S., Krasnick, Bradley A., Rozycki, Emily B., Jeffers, Gejae G. L., Grossman, Julie G., Highkin, Maureen K., Tang, Cynthia, Cabanski, Christopher R., Eteleeb, Abdallah, Mudd, Jacqueline, Goedegebuure, S. Peter, Luo, Jingqin, Mardis, Elaine R., Wilson, Richard K., Ley, Timothy J., Lockhart, Albert C., Fields, Ryan C., Maher, Christopher A.

“…Colorectal cancer (CRC) is the most common gastrointestinal malignancy in the U.S.A. and approximately 50% of patients develop metastatic disease (mCRC)…”
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A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project by Carithers, Latarsha J, Ardlie, Kristin, Barcus, Mary, Branton, Philip A, Britton, Angela, Buia, Stephen A, Compton, Carolyn C, DeLuca, David S, Peter-Demchok, Joanne, Gelfand, Ellen T, Guan, Ping, Korzeniewski, Greg E, Lockhart, Nicole C, Rabiner, Chana A, Rao, Abhi K, Robinson, Karna L, Roche, Nancy V, Sawyer, Sherilyn J, Segrè, Ayellet V, Shive, Charles E, Smith, Anna M, Sobin, Leslie H, Undale, Anita H, Valentino, Kimberly M, Vaught, Jim, Young, Taylor R, Moore, Helen M

“…The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and…”
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The Serpin Superfamily and Their Role in the Regulation and Dysfunction of Serine Protease Activity in COPD and Other Chronic Lung Diseases by Kelly-Robinson, Gillian A., Reihill, James A., Lundy, Fionnuala T., McGarvey, Lorcan P., Lockhart, John C., Litherland, Gary J., Thornbury, Keith D., Martin, S. Lorraine

“…Chronic obstructive pulmonary disease (COPD) is a debilitating heterogeneous disease characterised by unregulated proteolytic destruction of lung tissue…”
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The perioperative utility of 3D printed models in complex surgical care: feedback from 106 cases by Thorn, C, Ballard, J, Lockhart, C, Crone, A, Aarvold, A

“…3D models are an emerging tool for surgical planning, providing an augmented method for the visualisation of a patient's anatomy. As their use increases, more…”
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Small extracellular vesicles derived from synovial fibroblasts contain distinct miRNA profiles and contribute to chondrocyte damage in osteoarthritis by Asghar, Sabha, Litherland, Gary J, Cole, John J, McInnes, Iain B, Meek, R M D, Lockhart, John C, Goodyear, Carl S, Crilly, Anne

“…Small extracellular vesicles (sEV) derived from synovial fibroblasts (SF) represent a novel molecular mechanism regulating cartilage erosion in osteoarthritis…”
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Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology by Huesa, Carmen, Ortiz, Ana C, Dunning, Lynette, McGavin, Laura, Bennett, Louise, McIntosh, Kathryn, Crilly, Anne, Kurowska-Stolarska, Mariola, Plevin, Robin, van 't Hof, Rob J, Rowan, Andrew D, McInnes, Iain B, Goodyear, Carl S, Lockhart, John C, Ferrell, William R

“…Proteinase-activated receptor 2 (PAR2) deficiency protects against cartilage degradation in experimental osteoarthritis (OA). The wider impact of this pathway…”
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Thiazolidinediones: effects on insulin resistance and the cardiovascular system by Quinn, C E, Hamilton, P K, Lockhart, C J, McVeigh, G E

“…Thiazolidinediones (TZDs) have been used for the treatment of hyperglycaemia in type 2 diabetes for the past 10 years. They may delay the development of type 2…”
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Comment on: 'timing and clinical outcomes of tracheostomy in patients with COVID-19' by Lockhart, C, Carboni Bisso, I, Potenzoni, A, Bertoia, N, Arias, M, Ceballos, I F, Las Heras, M

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Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases by Carroll, Emma L, Bailo, Mariarca, Reihill, James A, Crilly, Anne, Lockhart, John C, Litherland, Gary J, Lundy, Fionnuala T, McGarvey, Lorcan P, Hollywood, Mark A, Martin, S Lorraine

“…Trypsin-like proteases (TLPs) belong to a family of serine enzymes with primary substrate specificities for the basic residues, lysine and arginine, in the P1…”
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Spatial and network analysis of U.S. livestock movements based on Interstate Certificates of Veterinary Inspection by Cabezas, A.H., Sanderson, M.W., Lockhart, C.Y., Riley, K.A., Hanthorn, C.J.

“…Livestock movements are a common pathway for the spread infectious diseases in a population. An understanding of livestock movement patterns is needed to…”
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Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models by Zhong, Hua, Sanchez, Cesar, Spitzer, Dirk, Spitrzer, Dirk, Plambeck-Suess, Stacy, Gibbs, Jesse, Hawkins, Williams G, Denardo, David, Gao, Feng, Pufahl, Robert A, Lockhart, Albert C, Xu, Mai, Linehan, David, Weber, Jason, Wang-Gillam, Andrea

“…Patients with pancreatic cancer have dismal prognoses, and novel therapies are urgently needed. Mutations of the KRAS oncogene occur frequently in pancreatic…”
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Moderate exercise protects against joint disease in a murine model of osteoarthritis by Huesa, C, Dunning, L, MacDougall, K, Fegen, M, Ortiz, A, McCulloch, K, McGrath, S, Litherland, G J, Crilly, A, Van 't Hof, R J, Ferrell, W R, Goodyear, C S, Lockhart, J C

“…Exercise is recommended as a non-pharmacological therapy for osteoarthritis (OA). Various exercise regimes, with differing intensities and duration, have been…”
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Classical eye signs in bacterial endocarditis by Loughrey, P B, Armstrong, D, Lockhart, C J

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The Ethical, Legal, and Social Implications Program of the National Human Genome Research Institute: Reflections on an Ongoing Experiment by McEwen, Jean E, Boyer, Joy T, Sun, Kathie Y, Rothenberg, Karen H, Lockhart, Nicole C, Guyer, Mark S

“…For more than 20 years, the Ethical, Legal, and Social Implications (ELSI) Program of the National Human Genome Research Institute has supported empirical and…”
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Community-associated Clostridium difficile infection among older people in Tayside, Scotland, is associated with antibiotic exposure and care home residence: cohort study with nested case-control by Marwick, Charis A, Yu, Ning, Lockhart, Michael C, McGuigan, Christopher C, Wiuff, Camilla, Davey, Peter G, Donnan, Peter T

“…To estimate the risks of community-associated Clostridium difficile infection (CA-CDI) among the population aged ≥ 65 years associated with antibiotic exposure…”
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Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation by Kelso, Elizabeth B, Lockhart, John C, Hembrough, Todd, Dunning, Lynette, Plevin, Robin, Hollenberg, Morley D, Sommerhoff, Christian P, McLean, John S, Ferrell, William R

“…Biological therapies such as tumor necrosis factor-alpha inhibitors have advanced the treatment of rheumatoid arthritis, but one-third of patients do not…”
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Phase I pharmacokinetic study of single agent trametinib in patients with advanced cancer and hepatic dysfunction by Voon, Pei Jye, Chen, Eric X, Chen, Helen X, Lockhart, Albert C, Sahebjam, Solmaz, Kelly, Karen, Vaishampayan, Ulka N, Subbiah, Vivek, Razak, Albiruni R, Renouf, Daniel J, Hotte, Sebastien J, Singh, Arti, Bedard, Philippe L, Hansen, Aaron R, Ivy, S Percy, Wang, Lisa, Stayner, Lee-Anne, Siu, Lillian L, Spreafico, Anna

“…Trametinib is an oral MEK 1/2 inhibitor, with a single agent recommended phase 2 dose (RP2D) of 2 mg daily (QD). This study was designed to evaluate RP2D,…”
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Rheumatic Disease: Protease-Activated Receptor-2 in Synovial Joint Pathobiology by McCulloch, Kendal, McGrath, Sarah, Huesa, Carmen, Dunning, Lynette, Litherland, Gary, Crilly, Anne, Hultin, Leif, Ferrell, William R, Lockhart, John C, Goodyear, Carl S

“…Protease-activated receptor-2 (PAR2) is one member of a small family of transmembrane, G-protein-coupled receptors. These receptors are activated cleavage of…”
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Phase II study of neoadjuvant therapy with docetaxel, cisplatin, panitumumab, and radiation therapy followed by surgery in patients with locally advanced adenocarcinoma of the distal esophagus (ACOSOG Z4051) by Lockhart, A.C., Reed, C.E., Decker, P.A., Meyers, B.F., Ferguson, M.K., Oeltjen, A.R., Putnam, J.B., Cassivi, S.D., Montero, A.J., Schefter, T.E.

“…Preoperative chemoradiotherapy (CRT) improves outcomes in patients with locally advanced but resectable adenocarcinoma of the esophagus. ACOSOG Z4051 evaluated…”
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Aerobic training-induced improvements in arterial stiffness are not sustained in older adults with multiple cardiovascular risk factors by Madden, K M, Lockhart, C, Cuff, D, Potter, T F, Meneilly, G S

“…There is a well-established relationship between increased arterial stiffness and cardiovascular mortality. We examined whether a long-term aerobic exercise…”
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