Search Results - "Locke, Julie M"

Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2-diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives by Matesic, Lidia, Locke, Julie M., Vine, Kara L., Ranson, Marie, Bremner, John B., Skropeta, Danielle

“…To further expand the structure–cytotoxic activity relationships of isatin derivatives and to reduce flexibility in substituent groups at nitrogen, 20…”
Get full text

N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines by Vine, Kara L., Belfiore, Lisa, Jones, Luke, Locke, Julie M., Wade, Samantha, Minaei, Elahe, Ranson, Marie

“…The search for novel anticancer therapeutics with the ability to overcome multi-drug resistance (MDR) mechanisms is of high priority. A class of molecules that…”
Get full text

Probing Molecular Shape. 1. Conformational Studies of 5-Hydroxyhexahydropyrimidine and Related Compounds by Locke, Julie M, Crumbie, Robyn L, Griffith, Renate, Bailey, Trevor D, Boyd, Susan, Roberts, John D

“…Understanding the factors that determine molecular shape enables scientists to begin to understand and tailor molecular properties and reactivity. Many…”
Get full text

In vitro cytotoxicity evaluation of some substituted isatin derivatives by Vine, Kara L., Locke, Julie M., Ranson, Marie, Pyne, Stephen G., Bremner, John B.

“…A range of substituted 1 H-indole-2,3-diones (isatins) were synthesized using standard procedures and their cytotoxicity evaluated against the human…”
Get full text

An Investigation into the Cytotoxicity and Mode of Action of Some Novel N-Alkyl-Substituted Isatins by Vine, Kara L, Locke, Julie M, Ranson, Marie, Pyne, Stephen G, Bremner, John B

“…A range of substituted N-alkylisatins were synthesized and their cytotoxicity evaluated against several cancer cell lines in vitro. SAR studies indicated that…”
Get full text

Competition between cyclisation and bisimine formation in the reaction of 1,3-diaminopropanes with aromatic aldehydes by Locke, Julie M., Griffith, Renate, Bailey, Trevor D., Crumbie, Robyn L.

“…Condensation of 1,3-diamines with aldehydes or ketones gives rise to two major products, the hexahydropyrimidine and the bisimine. Experimental studies of the…”
Get full text

N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents by Matesic, Lidia, Locke, Julie M., Bremner, John B., Pyne, Stephen G., Skropeta, Danielle, Ranson, Marie, Vine, Kara L.

“…A range of N-phenethyl, N-phenacyl, and N-(1- and 2-naphthylmethyl) derivatives of 5,7-dibromoisatin 2 were prepared by N-alkylation reactions. Their activity…”
Get full text

Anti-cancer activity of an acid-labile N -alkylisatin conjugate targeting the transferrin receptor by Indira Chandran, Vineesh, Matesic, Lidia, Locke, Julie M, Skropeta, Danielle, Ranson, Marie, Vine, Kara L

“…Abstract We have previously reported a series of pH-sensitive imine-linked N -alkylisatin prodrugs that are stable at pH 7.4, but readily cleaved at pH 4.5…”
Get full text

Electrically Induced Disassembly of Electroactive Multilayer Films Fabricated from Water Soluble Polythiophenes by Mawad, Damia, Molino, Paul J., Gambhir, Sanjeev, Locke, Julie M., Officer, David L., Wallace, Gordon G.

“…A novel approach to induce disassembly of electroactive multilayer films fabricated by the layer by layer assembly technique is reported. Electroactive…”
Get full text

Synthesis and hydrolytic evaluation of acid-labile imine-linked cytotoxic isatin model systems by Matesic, Lidia, Locke, Julie M., Vine, Kara L., Ranson, Marie, Bremner, John B., Skropeta, Danielle

“…In this study a series of isatin-based, pH-sensitive aryl imine derivatives with differing aromatic substituents and substitution patterns were synthesised and…”
Get full text

Selective targeting of 2′-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro by Vine, Kara L., Locke, Julie M., Bremner, John B., Pyne, Stephen G., Ranson, Marie

“…A urokinase targeting conjugate of 2′-deoxy-5-fluorouridine (5-FUdr) was synthesized and found to preferentially kill urokinase-over expressing cancer cells. A…”
Get full text

The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil by Watson, Clare A, Vine, Kara L, Locke, Julie M, Bezos, Anna, Parish, Christopher R, Ranson, Marie

“…Sulfated β-cyclodextrins (S-β-CDs) are useful excipients for improving the solubility of drugs. One such formulation incorporating 5-fluorouracil (5-FU),…”
Get full text

Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles by Stutchbury, Tamantha K, Vine, Kara L, Locke, Julie M, Chrisp, Jeremy S, Bremner, John B, Clingan, Philip R, Ranson, Marie

“…5-Fluorouracil (5-FU) in combination with its synergistic biomodulator folinic acid maintains a pivotal position in cancer chemotherapy. However, clinical…”
Get full text

Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate by Locke, Julie M, Stutchbury, Tamantha K, Vine, Kara L, Gamble, Allan B, Clingan, Philip R, Bremner, John B, Ranson, Marie

“…5-Fluorouracil in combination with its biomodulator folinic acid maintains a pivotal position in current anticancer treatment regimens. However, limitations in…”
Get full text

Corrigendum to “In vitro cytotoxicity evaluation of some substituted isatin derivatives” [Bioorg. Med. Chem. 15 (2007) 931–938] by Vine, Kara L., Locke, Julie M., Ranson, Marie, Benkendorff, Kirsten, Pyne, Stephen G., Bremner, John B.

Get full text