Search Results - "Locke, Jennifer A."

Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer by Locke, Jennifer A, Guns, Emma S, Lubik, Amy A, Adomat, Hans H, Hendy, Stephen C, Wood, Catherine A, Ettinger, Susan L, Gleave, Martin E, Nelson, Colleen C

“…Although systemic androgen deprivation prolongs life in advanced prostate cancer, remissions are temporary because patients almost uniformly progress to a…”
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Treatment of varicocele in children and adolescents: A systematic review and meta-analysis of randomized controlled trials by Locke, Jennifer A., Noparast, Maryam, Afshar, Kourosh

“…The prevalence of varicoceles is as high as 15% in children and adolescents. Optimal management of varicoceles has not been consolidated. Options include…”
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Copy number alterations of c‐MYC and PTEN are prognostic factors for relapse after prostate cancer radiotherapy by Zafarana, Gaetano, Ishkanian, Adrian S., Malloff, Chad A., Locke, Jennifer A., Sykes, Jenna, Thoms, John, Lam, Wan L., Squire, Jeremy A., Yoshimoto, Maisa, Ramnarine, Varune Rohan, Meng, Alice, Ahmed, Omar, Jurisca, Igor, Milosevic, Michael, Pintilie, Melania, van der Kwast, Theo, Bristow, Robert G.

“…Despite the use of PSA, Gleason score, and T‐category as prognosticators in intermediate‐risk prostate cancer, 20–40% of patients will fail local therapy. In…”
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Insulin Increases De Novo Steroidogenesis in Prostate Cancer Cells by LUBIK, Amy A, GUNTER, Jennifer H, HENDY, Stephen C, LOCKE, Jennifer A, ADOMAT, Hans H, THOMPSON, Vanessa, HERINGTON, Adrian, GLEAVE, Martin E, POLLAK, Michael, NELSON, Colleen C

“…Androgen-dependent pathways regulate maintenance and growth of normal and malignant prostate tissues. Androgen deprivation therapy (ADT) exploits this…”
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A comprehensive review of adult enuresis by Akhavizadegan, Hamed, Locke, Jennifer A, Stothers, Lynn, Kavanagh, Alex

“…Nocturnal enuresis (NE) is a combined symptom of nocturia and urinary incontinence. In this review, we aim to summarize the current literature on NE in terms…”
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Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model by Leon, Carlos G., Locke, Jennifer A., Adomat, Hans H., Etinger, Susan L., Twiddy, Alexis L., Neumann, Rachel D., Nelson, Colleen C., Guns, Emma S., Wasan, Kishor M.

“…BACKGROUND Emerging evidence suggests that androgens and the androgen receptor (AR) are important mediators of castration‐resistant prostate cancer (CRPC)…”
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Diagnosis and Management of Kock Afferent Nipple Valve Obstruction by Locke, Jennifer A., Neu, Sarah, Herschorn, Sender

“…To characterize afferent nipple valve obstruction in Kock diversions presenting with hydronephrosis and discuss appropriate work-up and management. We…”
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Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance by Locke, Jennifer A., Guns, Emma S. Tomlinson, Lehman, Melanie L., Ettinger, Susan, Zoubeidi, Amina, Lubik, Amy, Margiotti, Katia, Fazli, Ladan, Adomat, Hans, Wasan, Kishor M., Gleave, Martin E., Nelson, Colleen C.

“…BACKGROUND De novo androgen synthesis and subsequent androgen receptor (AR) activation has recently been shown to contribute to castration‐resistant prostate…”
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Prevalence and repair patterns of vesicovaginal fistula: a large retrospective population-based cohort analysis by Neu, Sarah, Locke, Jennifer A., Zhang, Bo, Saskin, Refik, Herschorn, Sender

“…Purpose Vesicovaginal fistulae (VVF) have a significant negative impact on quality of life, with failed surgical repair resulting in ongoing morbidity. Our aim…”
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A Retrospective Look at Term Outcomes After Definitive Surgical Repair for Traumatic Pelvic Fracture Urethral Injuries – Does Initial Management Make a Difference? by Neu, Sarah, Remondini, Taylor, Hird, Amanda, Locke, Jennifer A., Herschorn, Sender, Kodama, Ronald

“…To compare the long-term outcomes of initial management of pelvic fracture urethral injury (PFUI) in a large cohort of trauma patients undergoing urethral…”
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Virtual medicine in urology: Is it here to stay? by Armstrong, Madeleine, Koo, Ryan, Locke, Jennifer A

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Morbidity and predictors of delayed recognition of iatrogenic ureteric injuries by Locke, Jennifer A, Neu, Sarah, Herschorn, Sender

“…Although intraoperative iatrogenic ureteric injuries (IUI) are rare, significant consequences can occur if they are unrecognized at the time. The focus of our…”
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Characterizing the cortical pathways underlying visual trigger induced urinary urgency incontinence by functional MRI by Locke, Jennifer A., Macnab, Andrew, Garg, Saurabh, McKeown, Martin, Stothers, Lynn

“…Aims Visual triggers have long been recognized clinically to stimulate urgency urinary incontinence (UUI). Current pathophysiology recognizes the importance of…”
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The Use of Metformin in Overactive Bladder: A Retrospective Nested Case-control, Population-based Analysis by Neu, Sarah, Matta, Rano, Locke, Jennifer A., Troke, Natalie, Tadrous, Mina, Saskin, Refik, Rebullar, Karla, Nam, Robert, Herschorn, Sender

“…To determine if metformin use is associated with a lower rate of overactive bladder (OAB) medication use. Metformin facilitates the proliferation and migration…”
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Case - Chronic urinary retention in elderly women: Workup and management by Landells, Graham, Locke, Jennifer A

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A novel communication role for CYP17A1 in the progression of castration-resistant prostate cancer by Locke, Jennifer A., Fazli, Ladan, Adomat, Hans, Smyl, Jil, Weins, Kristin, Lubik, Amy A., Hales, Dale B., Nelson, Colleen C., Gleave, Martin E., Tomlinson Guns, Emma S.

“…BACKGROUND CYP17A1 is currently a target for total androgen blockade in advanced prostate cancer (CaP) patients. After castration, or removal of testicular…”
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Reply to “The Role of Metformin in Overactive Bladder: More Studies Are Warranted” by Neu, Sarah, Matta, Rano, Locke, Jennifer A., Troke, Natalie, Tadrous, Mina, Saskin, Refik, Rebullar, Karla, Nam, Robert, Herschorn, Sender

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Pilot study to assess the feasibility of self-administered, low-dose methoxyflurane for cystoscopic procedures by Locke, Jennifer A, Neu, Sarah, Lawrence, Joanne, Herschorn, Sender

“…Methoxyflurane (MEO F) (Penthrox™) is an inhaled, self-administered, non-opioid analgesic approved by Health Canada for the short-term relief of moderate to…”
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Standing open magnetic resonance imaging improves detection and staging of pelvic organ prolapse by Stothers, Lynn, Locke, Jennifer A, Abdulaziz, Marwa, Lazare, Darren, Kavanagh, Alex, Macnab, Andrew

“…The role of imaging in pelvic organ prolapse (POP) assessment is unclear. Open magnetic resonance imaging (MRI) systems have a configuration that allows for…”
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Triamcinolone acetonide injections for the treatment of recalcitrant post-radical prostatectomy vesicourethral anastomotic stenosis: A retrospective look at efficacy and safety by Neu, Sarah, Vigil, Humberto, Locke, Jennifer A, Herschorn, Sender

“…We aimed to evaluate the success of bladder neck injections of triamcinolone at the time of transurethral bladder neck incision (BNI) for prevention of…”
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