Search Results - "Locke, Jeffrey B"

Novel Ribosomal Mutations in Staphylococcus aureus Strains Identified through Selection with the Oxazolidinones Linezolid and Torezolid (TR-700) by LOCKE, Jeffrey B, HILGERS, Mark, SHAW, Karen Joy

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Tedizolid for the Management of Human Infections: In Vitro Characteristics by Locke, Jeffrey B., Zurenko, Gary E., Shaw, Karen Joy, Bartizal, Kenneth

“…The emerging antibiotic resistance of Gram-positive pathogens represents a significant challenge to the management of human infections. The novel oxazolidinone…”
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Mutations in Ribosomal Protein L3 Are Associated with Oxazolidinone Resistance in Staphylococci of Clinical Origin by LOCKE, Jeffrey B, HILGERS, Mark, SHAW, Karen Joy

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Anthracimycin, a Potent Anthrax Antibiotic from a Marine-Derived Actinomycete by Jang, Kyoung Hwa, Nam, Sang-Jip, Locke, Jeffrey B., Kauffman, Christopher A., Beatty, Deanna S., Paul, Lauren A., Fenical, William

“…Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine‐derived actinomycete in saline culture, shows significant activity toward…”
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Absorption, distribution, metabolism, and excretion of the novel antibacterial prodrug tedizolid phosphate by Ong, Voon, Flanagan, Shawn, Fang, Edward, Dreskin, Howard J, Locke, Jeffrey B, Bartizal, Kenneth, Prokocimer, Philippe

“…Tedizolid phosphate is a novel antibacterial prodrug with potent activity against Gram-positive pathogens. In vitro and in vivo studies demonstrated that the…”
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Structure-Activity Relationships of Diverse Oxazolidinones for Linezolid-Resistant Staphylococcus aureus Strains Possessing the cfr Methyltransferase Gene or Ribosomal Mutations by LOCKE, Jeffrey B, FINN, John, HILGERS, Mark, MORALES, Gracia, RAHAWI, Shahad, KEDAR G. C, PICAZO, Juan José, IM, Weonbin, SHAW, Karen Joy, STEIN, Jeffrey L

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Results of the Surveillance of Tedizolid Activity and Resistance Program: in vitro susceptibility of Gram-positive pathogens collected in 2011 and 2012 from the United States and Europe by Sahm, Daniel F, Deane, Jennifer, Bien, Paul A, Locke, Jeffrey B, Zuill, Douglas E, Shaw, Karen J, Bartizal, Ken F

“…Abstract The in vitro activity and spectrum of tedizolid and comparators were analyzed against 6884 Gram-positive clinical isolates collected from multiple US…”
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Genetic Environment and Stability of cfr in Methicillin-Resistant Staphylococcus aureus CM05 by LOCKE, Jeffrey B, RAHAWI, Shahad, LAMARRE, Jacqueline, MANKIN, Alexander S, SHAW, Karen Joy

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Low Fitness Cost of the Multidrug Resistance Gene cfr by LAMARRE, Jacqueline M, LOCKE, Jeffrey B, SHAW, Karen J, MANKIN, Alexander S

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The IL-8 protease SpyCEP/ScpC of group A Streptococcus promotes resistance to neutrophil killing by Zinkernagel, Annelies S, Timmer, Anjuli M, Pence, Morgan A, Locke, Jeffrey B, Buchanan, John T, Turner, Claire E, Mishalian, Inbal, Sriskandan, Shiranee, Hanski, Emanuel, Nizet, Victor

“…Interleukin-8 (IL-8) promotes neutrophil-mediated host defense through its chemoattractant and immunostimulatory activities. The Group A Streptococcus (GAS)…”
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Comparison of In Vitro Killing Activity of Rezafungin, Anidulafungin, Caspofungin, and Micafungin against Four Candida auris Clades in RPMI-1640 in the Absence and Presence of Human Serum by Kovács, Renátó, Tóth, Zoltán, Locke, Jeffrey B, Forgács, Lajos, Kardos, Gábor, Nagy, Fruzsina, Borman, Andrew M, Majoros, László

“…is an emerging and frequently multidrug-resistant pathogen against which the echinocandins are the preferred therapeutic option. We compared killing activities…”
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Elevated Linezolid Resistance in Clinical cfr-Positive Staphylococcus aureus Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3 by LOCKE, Jeffrey B, MORALES, Gracia, HILGERS, Mark, KEDAR G. C, RAHAWI, Shahad, PICAZO, Juan José, SHAW, Karen Joy, STEIN, Jeffrey L

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Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species by Bartizal, Ken F., Donatelli, Joanna L., Almaguer, Amanda L., Locke, Jeffrey B.

“…Background. While echinocandins demonstrate excellent efficacy against Candida species in disseminated infections and demonstrate potent minimal inhibitory…”
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In Vivo Efficacy of Rezafungin, Anidulafungin, Caspofungin, and Micafungin against Four Candida auris Clades in a Neutropenic Mouse Bloodstream Infection Model by Balázsi, Dávid, Tóth, Zoltán, Locke, Jeffrey B, Borman, Andrew M, Forgács, Lajos, Balla, Noémi, Kovács, Fruzsina, Kovács, Renátó, Amano, Chiaki, Baran, Tugba Ilay, Majoros, László

“…Rezafungin is the first new drug approved to treat candidaemia and invasive candidiasis in more than 10 years. However, data are scant on the in vivo efficacy…”
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Streptococcus iniae M-like protein contributes to virulence in fish and is a target for live attenuated vaccine development by Locke, Jeffrey B, Aziz, Ramy K, Vicknair, Mike R, Nizet, Victor, Buchanan, John T

“…Streptococcus iniae is a significant pathogen in finfish aquaculture, though knowledge of virulence determinants is lacking. Through pyrosequencing of the S…”
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Relative Frequency of Paradoxical Growth and Trailing Effect with Caspofungin, Micafungin, Anidulafungin, and the Novel Echinocandin Rezafungin against Candida Species by Tóth, Zoltán, Forgács, Lajos, Kardos, Tamás, Kovács, Renátó, Locke, Jeffrey B, Kardos, Gábor, Nagy, Fruzsina, Borman, Andrew M, Adnan, Awid, Majoros, László

“…Rezafungin is a next-generation echinocandin that has favorable pharmacokinetic properties. We compared the occurrence of paradoxical growth (PG) and trailing…”
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Rezafungin (CD101) demonstrates potent in vitro activity against Aspergillus, including azole-resistant Aspergillus fumigatus isolates and cryptic species by Wiederhold, Nathan P, Locke, Jeffrey B, Daruwala, Paul, Bartizal, Ken

“…Rezafungin is an investigational echinocandin under development for the treatment and prevention of invasive fungal infections, with a long half-life in humans…”
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Streptococcus iniae Capsule Impairs Phagocytic Clearance and Contributes to Virulence in Fish by LOCKE, Jeffrey B, CALVIN, Kelly M, DATTA, Anup K, PATEL, Silpa K, NAIDU, Nandita N, NEELY, Melody N, NIZET, Victor, BUCHANAN, John T

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In vitro activity of rezafungin against common and rare Candida species and Saccharomyces cerevisiae by Tóth, Zoltán, Forgács, Lajos, Locke, Jeffrey B, Kardos, Gábor, Nagy, Fruzsina, Kovács, Renátó, Szekely, Adrien, Borman, Andrew M, Majoros, László

“…Abstract Background Rezafungin is a novel echinocandin with excellent activity against common Candida species; however, limited data are available regarding…”
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Multicentre validation of a modified EUCAST MIC testing method and development of associated epidemiologic cut-off (ECOFF) values for rezafungin by Arendrup, Maiken Cavling, Arikan-Akdagli, Sevtap, Castanheira, Mariana, Guinea, Jesus, Locke, Jeffrey B, Meletiadis, Joseph, Zaragoza, Oscar

“…Abstract Objectives Rezafungin EUCAST MIC testing has been associated with notable inter-laboratory variation, which prevented ECOFF setting for C. albicans…”
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