Search Results - "Lockamy, Elizabeth L"

High-throughput FRET assay yields allosteric SERCA activators by Cornea, Razvan L, Gruber, Simon J, Lockamy, Elizabeth L, Muretta, Joseph M, Jin, Dongzhu, Chen, Jiqiu, Dahl, Russell, Bartfai, Tamas, Zsebo, Krisztina M, Gillispie, Gregory D, Thomas, David D

“…Using fluorescence resonance energy transfer (FRET), we performed a high-throughput screen (HTS) in a reconstituted membrane system, seeking compounds that…”
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Site-Specific Methionine Oxidation Initiates Calmodulin Degradation by the 20S Proteasome by Balog, Edward M, Lockamy, Elizabeth L, Thomas, David D, Ferrington, Deborah A

“…The proteasome is a key intracellular protease that regulates processes, such as signal transduction and protein quality control, through the selective…”
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Lipid-Mediated Folding/Unfolding of Phospholamban as a Regulatory Mechanism for the Sarcoplasmic Reticulum Ca2+-ATPase by Gustavsson, Martin, Traaseth, Nathaniel J., Karim, Christine B., Lockamy, Elizabeth L., Thomas, David D., Veglia, Gianluigi

“…The integral membrane protein complex between phospholamban (PLN) and sarcoplasmic reticulum Ca2+-ATPase (SERCA) regulates cardiac contractility. In the…”
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Functional and physical competition between phospholamban and its mutants provides insight into the molecular mechanism of gene therapy for heart failure by Lockamy, Elizabeth L., Cornea, Razvan L., Karim, Christine B., Thomas, David D.

“…► LOF mutants of PLB can compete with WT-PLB and relieve SERCA inhibition. ► Competition measured by both ATPase activity and FRET. ► For PLB and its mutants,…”
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On the Intractability of Estrogen-Related Receptor α as a Target for Activation by Small Molecules by Hyatt, Stephen M, Lockamy, Elizabeth L, Stein, Rebecca A, McDonnell, Donald P, Miller, Aaron B, Orband-Miller, Lisa A, Willson, Timothy M, Zuercher, William J

“…The estrogen-related receptor α (ERRα) is a potential target for activation in the treatment of metabolic disease. To date, no small-molecule agonists of ERRα…”
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Simulations of Fluorescent Probes Attached to SERCA by Svensson, Bengt, Dong, Xiaoqiong, Lockamy, Elizabeth L., Young, Howard S., Thomas, David D.

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Simulations of Fluorescent Probes Attached to SERCA by Svensson, Bengt, Lockamy, Elizabeth L., Dong, Daphne, Young, Howard S., Thomas, David D.

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Probing the Molecular Mechanism of SERCA-PLB Regulation by Time-Resolved FRET by Lockamy, Elizabeth L., Cornea, Razvan L., Karim, Christine B., Thomas, David D.

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Molecular Dynamics Simulations of the IAEDANS Fluorescent Probe Attached to the Sarcoplasmic Reticulum Ca2+-ATpase (serca) by Svensson, Bengt, Lockamy, Elizabeth L., Young, Howard S., Thomas, David D.

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Molecular Dynamics Simulations of the IAEDANS Fluorescent Probe Attached to the Sarcoplasmic Reticulum Ca 2+-ATpase (serca) by Svensson, Bengt, Lockamy, Elizabeth L., Young, Howard S., Thomas, David D.

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Probing the Mechanism of SERCA-PLB Regulation by Time-Resolved Fret by Lockamy, Elizabeth L., Cornea, Razvan L., Karim, Christine B., Thomas, David D.

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Conformational Dynamics of a Fluorescent Probe Attached to the Sarcoplasmic Reticulum Ca2+-ATPase (SERCA) Studied by Molecular Simulations by Svensson, Bengt, Lockamy, Elizabeth L., Young, Howard S., Thomas, David D.

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Nucleotide Movement within SERCA Detected by FRET Resolved Simultaneously on the Nanosecond and Millisecond Time Scales by Lockamy, Elizabeth L., Kast, David, Negrashov, Igor, Young, Howard S., Thomas, David D.

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Structure-Based Design of Phospholamban Mutants for Gene Therapy by Gruber, Simon J., Ha, Kim N., Lockamy, Elizabeth L., Cornea, Razvan L., Hajjar, Roger J., Veglia, Gianluigi, Thomas, David D.

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On the Intractability of Estrogen-Related Receptor a as a Target for Activation by Small Molecules by HYATT, Stephen M, LOCKAMY, Elizabeth L, STEIN, Rebecca A, MCDONNELL, Donald P, MILLER, Aaron B, ORBAND-MILLER, Lisa A, WILLSON, Timothy M, ZUERCHER, William J

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