Search Results - "Lock, Lye T."

Expansion and differentiation of human embryonic stem cells to endoderm progeny in a microcarrier stirred-suspension culture by Lock, Lye T, Tzanakakis, Emmanuel S

“…Embryonic stem cells (ESCs) with their abilities for extensive proliferation and multi-lineage differentiation can serve as a renewable source of cellular…”
Get more information

Peak MSC-Are We There Yet? by Olsen, Timothy R, Ng, Kelvin S, Lock, Lye T, Ahsan, Tabassum, Rowley, Jon A

“…Human mesenchymal stem cells (hMSCs) are a critical raw material for many regenerative medicine products, including cell-based therapies, engineered tissues,…”
Get full text

Propagation of embryonic stem cells in stirred suspension without serum by Kehoe, Daniel E., Lock, Lye T., Parikh, Abhirath, Tzanakakis, Emmanuel S.

“…Embryonic stem cells (ESCs) with their unlimited capacity for self‐renewal and ability to differentiate along multiple cell lineages are a superb starting…”
Get full text

Stem/Progenitor cell sources of insulin-producing cells for the treatment of diabetes by Lock, Lye T, Tzanakakis, Emmanuel S

“…Patients with diabetes experience decreased insulin secretion that is linked to a significant reduction in the number of islet cells. Reversal of diabetes can…”
Get more information

Scalable stirred-suspension bioreactor culture of human pluripotent stem cells by Kehoe, Daniel E, Jing, Donghui, Lock, Lye T, Tzanakakis, Emmanuel S

“…Advances in stem cell biology have afforded promising results for the generation of various cell types for therapies against devastating diseases. However, a…”
Get more information

Pseudoislets in stirred-suspension culture exhibit enhanced cell survival, propagation and insulin secretion by Lock, Lye T., Laychock, Suzanne G., Tzanakakis, Emmanuel S.

“…Cells from primary islets and beta-cell lines form pseudoislets (PIs) in static cultures. Interestingly, MIN6 beta-cells with aberrant regulation of…”
Get full text

Standardized biosynthesis of flavan-3-ols with effects on pancreatic beta-cell insulin secretion by Chemler, Joseph A, Lock, Lye T, Koffas, Mattheos A. G, Tzanakakis, Emmanuel S

“…Flavan-3-ols, such as green tea catechins represent a major group of phenolic compounds with significant medicinal properties. We describe the construction and…”
Get full text