Search Results - "Lock, John"

Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture by Moshksayan, Khashayar, Kashaninejad, Navid, Warkiani, Majid Ebrahimi, Lock, John G., Moghadas, Hajar, Firoozabadi, Bahar, Saidi, Mohammad Said, Nguyen, Nam-Trung

“…A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids provide similar metabolism, proliferation, and species…”
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Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis by Lock, John G., Jones, Matthew C., Askari, Janet A., Gong, Xiaowei, Oddone, Anna, Olofsson, Helene, Göransson, Sara, Lakadamyali, Melike, Humphries, Martin J., Strömblad, Staffan

“…Adhesion to the extracellular matrix persists during mitosis in most cell types. However, while classical adhesion complexes, such as focal adhesions, do and…”
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Clathrin-containing adhesion complexes by Lock, John G, Baschieri, Francesco, Jones, Matthew C, Humphries, Jonathan D, Montagnac, Guillaume, Strömblad, Staffan, Humphries, Martin J

“…An understanding of the mechanisms whereby cell adhesion complexes (ACs) relay signals bidirectionally across the plasma membrane is necessary to interpret the…”
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Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning by Burkhardt, Daniel B, San Juan, Beatriz P, Lock, John G, Krishnaswamy, Smita, Chaffer, Christine L

“…Phenotypic plasticity describes the ability of cancer cells to undergo dynamic, nongenetic cell state changes that amplify cancer heterogeneity to promote…”
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KIF13A‐regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration by Gong, Xiaowei, Didan, Yuliia, Lock, John G, Strömblad, Staffan

“…Membrane blebbing‐dependent (blebby) amoeboid migration can be employed by lymphoid and cancer cells to invade 3D‐environments. Here, we reveal a mechanism by…”
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Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions by Spiess, Matthias, Hernandez-Varas, Pablo, Oddone, Anna, Olofsson, Helene, Blom, Hans, Waithe, Dominic, Lock, John G, Lakadamyali, Melike, Strömblad, Staffan

“…Integrins are the core constituents of cell-matrix adhesion complexes such as focal adhesions (FAs) and play key roles in physiology and disease. Integrins…”
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Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin by Lock, John G, Stow, Jennifer L

“…E-cadherin plays an essential role in cell polarity and cell-cell adhesion; however, the pathway for delivery of E-cadherin to the basolateral membrane of…”
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Oxidative Chemical Vapor Deposition of Electrically Conducting Poly(3,4-ethylenedioxythiophene) Films by Lock, John P, Im, Sung Gap, Gleason, Karen K

“…An oxidative chemical vapor deposition (CVD) process is presented as an alternative to conventional solution-based processing of…”
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Appropriate screening interval to detect the development of chronic metabolic diseases by Sung, Ki-Chul, Kyung Yoo, Tae, Yeon Lee, Mi, Paul Lock, John

“…We conducted a cohort study to determine the screening intervals of metabolic disorders. Participants without diabetes mellitus (DM), hypertension (HTN),…”
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A 24‐week, randomized, double‐blind, active‐controlled clinical trial comparing bexagliflozin with sitagliptin as an adjunct to metformin for the treatment of type 2 diabetes in adults by Halvorsen, Yuan‐Di, Lock, John P., Zhou, Wenjiong, Zhu, Fang, Freeman, Mason W.

“…Aim To compare the relative safety and effectiveness of bexagliflozin and sitagliptin as adjuncts to metformin for the treatment of adults with type 2…”
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TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis by Nyström, Sanna, Antoine, Daniel J, Lundbäck, Peter, Lock, John G, Nita, Andreia F, Högstrand, Kari, Grandien, Alf, Erlandsson-Harris, Helena, Andersson, Ulf, Applequist, Steven E

“…Infection of macrophages by bacterial pathogens can trigger Toll‐like receptor (TLR) activation as well as Nod‐like receptors (NLRs) leading to inflammasome…”
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Chemical biology approaches targeting the actin cytoskeleton through phenotypic screening by Bryce, Nicole S, Hardeman, Edna C, Gunning, Peter W, Lock, John G

“…The actin cytoskeleton is dysregulated in cancer, yet this critical cellular machinery has not translated as a druggable clinical target due to cardio-toxic…”
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Genomic and Phenotypic Biomarkers for Precision Medicine Guidance in Advanced Prostate Cancer by Davoudi, Fatemeh, Moradi, Afshin, Becker, Therese M., Lock, John G., Abbey, Brian, Fontanarosa, Davide, Haworth, Annette, Clements, Judith, Ecker, Rupert C., Batra, Jyotsna

“…Opinion statement Prostate cancer (PCa) is the second most diagnosed malignant neoplasm and is one of the leading causes of cancer-related death in men…”
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Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells by Khan, Tanzila, Lock, John G., Ma, Yafeng, Harman, David G., de Souza, Paul, Chua, Wei, Balakrishnar, Bavanthi, Scott, Kieran F., Becker, Therese M.

“…Androgen receptor variant 7 (AR-V7) is an important biomarker to guide treatment options for castration-resistant prostate cancer (CRPC) patients. Its…”
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Risk Factors Associated With Severe Hypoglycemia in Older Adults With Type 1 Diabetes by Weinstock, Ruth S, DuBose, Stephanie N, Bergenstal, Richard M, Chaytor, Naomi S, Peterson, Christina, Olson, Beth A, Munshi, Medha N, Perrin, Alysa J S, Miller, Kellee M, Beck, Roy W, Liljenquist, David R, Aleppo, Grazia, Buse, John B, Kruger, Davida, Bhargava, Anuj, Goland, Robin S, Edelen, Rachel C, Pratley, Richard E, Peters, Anne L, Rodriguez, Henry, Ahmann, Andrew J, Lock, John-Paul, Garg, Satish K, Rickels, Michael R, Hirsch, Irl B

“…Severe hypoglycemia is common in older adults with long-standing type 1 diabetes, but little is known about factors associated with its occurrence. A…”
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Outcomes of inadequate empiric therapy and timing of newer antibacterial therapy in hospitalized adults with culture-positive Enterobacterales and Pseudomonas aeruginosa: a multicenter analysis by Riccobene, Todd, Ye, Gang, Lock, John, Yu, Kalvin C, Ai, ChinEn, Gregory, Sara, Gupta, Vikas

“…Infections caused by multi-drug resistant Gram-negative pathogens are associated with worse clinical outcomes in critically ill patients. We evaluated hospital…”
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1117-P: Cardiovascular and Glycemic Benefits of Bexagliflozin as an Adjunct to Metformin for the Treatment of Type 2 Diabetes in Adults: A 24-Week, Randomized, Double-Blind, Placebo-Controlled Trial by HALVORSEN, YUAN-DI C., LOCK, JOHN P., FREEMAN, MASON W.

“…Bexagliflozin is a potent and selective sodium glucose co-transporter 2 inhibitor. To evaluate the safety and effectiveness of bexagliflozin as an adjunct to…”
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Cell–matrix adhesion complexes: Master control machinery of cell migration by Lock, John G, Wehrle-Haller, Bernhard, Strömblad, Staffan

“…Abstract Cell–matrix adhesion complexes (CMACs) are foci of cellular attachment to the extracellular matrix (ECM). This attachment, mediated by integrins and…”
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Disentangling Membrane Dynamics and Cell Migration; Differential Influences of F-actin and Cell-Matrix Adhesions by Kowalewski, Jacob M, Shafqat-Abbasi, Hamdah, Jafari-Mamaghani, Mehrdad, Endrias Ganebo, Bereket, Gong, Xiaowei, Strömblad, Staffan, Lock, John G

“…Cell migration is heavily interconnected with plasma membrane protrusion and retraction (collectively termed "membrane dynamics"). This makes it difficult to…”
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Using Systems Microscopy to Understand the Emergence of Cell Migration from Cell Organization by Strömblad, Staffan, Lock, John G

“…Cell migration is a dynamic process that emerges from fine-tuned networks coordinated in three-dimensional space, spanning molecular, subcellular, and cellular…”
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